{"id":"https://openalex.org/W4390483972","doi":"https://doi.org/10.1016/j.cmpb.2023.108004","title":"Spatiotemporal modeling of radiopharmaceutical transport in solid tumors: Application to 177Lu-PSMA therapy of prostate cancer","display_name":"Spatiotemporal modeling of radiopharmaceutical transport in solid tumors: Application to 177Lu-PSMA therapy of prostate cancer","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4390483972","doi":"https://doi.org/10.1016/j.cmpb.2023.108004","pmid":"https://pubmed.ncbi.nlm.nih.gov/38215660"},"language":"en","primary_location":{"is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cmpb.2023.108004","pdf_url":null,"source":{"id":"https://openalex.org/S138959710","display_name":"Computer Methods and Programs in Biomedicine","issn_l":"0169-2607","issn":["0169-2607","1872-7565"],"is_oa":false,"is_in_doaj":false,"is_indexed_in_scopus":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},"type":"article","type_crossref":"journal-article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006112540","display_name":"Anahita Piranfar","orcid":"https://orcid.org/0009-0003-0751-5226"},"institutions":[{"id":"https://openalex.org/I80543232","display_name":"K.N.Toosi University of Technology","ror":"https://ror.org/0433abe34","country_code":"IR","type":"funder","lineage":["https://openalex.org/I80543232"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Anahita Piranfar","raw_affiliation_strings":["Department of Mechanical Engineering, K. N. Toosi University of Technology, Tehran, Iran"],"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, K. N. Toosi University of Technology, Tehran, Iran","institution_ids":["https://openalex.org/I80543232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026191305","display_name":"M. Soltani","orcid":"https://orcid.org/0000-0003-0878-6274"},"institutions":[{"id":"https://openalex.org/I80543232","display_name":"K.N.Toosi University of Technology","ror":"https://ror.org/0433abe34","country_code":"IR","type":"funder","lineage":["https://openalex.org/I80543232"]},{"id":"https://openalex.org/I151746483","display_name":"University of Waterloo","ror":"https://ror.org/01aff2v68","country_code":"CA","type":"funder","lineage":["https://openalex.org/I151746483"]}],"countries":["CA","IR"],"is_corresponding":true,"raw_author_name":"M. Soltani","raw_affiliation_strings":["Centre for Biotechnology and Bioengineering (CBB), University of Waterloo, Waterloo, ON, Canada","Department of Electrical and Computer Engineering, University of Waterloo, ON, Canada","Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada","Department of Mechanical Engineering, K. N. Toosi University of Technology, Tehran, Iran"],"affiliations":[{"raw_affiliation_string":"Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada","institution_ids":[]},{"raw_affiliation_string":"Department of Mechanical Engineering, K. N. Toosi University of Technology, Tehran, Iran","institution_ids":["https://openalex.org/I80543232"]},{"raw_affiliation_string":"Centre for Biotechnology and Bioengineering (CBB), University of Waterloo, Waterloo, ON, Canada","institution_ids":["https://openalex.org/I151746483"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Waterloo, ON, Canada","institution_ids":["https://openalex.org/I151746483"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026042311","display_name":"Farshad Moradi Kashkooli","orcid":"https://orcid.org/0000-0003-4338-8538"},"institutions":[{"id":"https://openalex.org/I80543232","display_name":"K.N.Toosi University of Technology","ror":"https://ror.org/0433abe34","country_code":"IR","type":"funder","lineage":["https://openalex.org/I80543232"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Farshad M. Kashkooli","raw_affiliation_strings":["Department of Mechanical Engineering, K. N. Toosi University of Technology, Tehran, Iran"],"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, K. N. Toosi University of Technology, Tehran, Iran","institution_ids":["https://openalex.org/I80543232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077969822","display_name":"Carlos Uribe","orcid":null},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"funder","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Carlos F. Uribe","raw_affiliation_strings":["Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada","Department of Radiology, University of British Columbia, Vancouver, BC, Canada","Functional Imaging, BC Cancer, Vancouver, BC, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada","institution_ids":[]},{"raw_affiliation_string":"Functional Imaging, BC Cancer, Vancouver, BC, Canada","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021438906","display_name":"Arman Rahmim","orcid":"https://orcid.org/0000-0002-9980-2403"},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"funder","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Arman Rahmim","raw_affiliation_strings":["Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada","Department of Radiology, University of British Columbia, Vancouver, BC, Canada","Functional Imaging, BC Cancer, Vancouver, BC, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada","institution_ids":[]},{"raw_affiliation_string":"Functional Imaging, BC Cancer, Vancouver, BC, Canada","institution_ids":[]}]}],"institution_assertions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5026191305"],"corresponding_institution_ids":["https://openalex.org/I80543232","https://openalex.org/I151746483"],"apc_list":{"value":2880,"currency":"USD","value_usd":2880},"apc_paid":null,"fwci":7.938,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.999976,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"245","issue":null,"first_page":"108004","last_page":"108004"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9994,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9994,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9992,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9933,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/internalization","display_name":"Internalization","score":0.8892559},{"id":"https://openalex.org/keywords/extravasation","display_name":"Extravasation","score":0.6449616}],"concepts":[{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.8892559},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.65099716},{"id":"https://openalex.org/C2779540182","wikidata":"https://www.wikidata.org/wiki/Q1076345","display_name":"Extravasation","level":2,"score":0.6449616},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.55113214},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.48446345},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.473148},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47041968},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.47028163},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.46943358},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.43622047},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4341075},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.43351138},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.4199202},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.39850998},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3773047},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.34231922},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32116467},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.28457308},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24837518},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.23462477},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18853632},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16153839},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.120437205},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004151","descriptor_name":"Dipeptides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"","qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cmpb.2023.108004","pdf_url":null,"source":{"id":"https://openalex.org/S138959710","display_name":"Computer Methods and Programs in Biomedicine","issn_l":"0169-2607","issn":["0169-2607","1872-7565"],"is_oa":false,"is_in_doaj":false,"is_indexed_in_scopus":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},{"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38215660","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_indexed_in_scopus":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.82,"id":"https://metadata.un.org/sdg/3"}],"grants":[{"funder":"https://openalex.org/F4320329172","funder_display_name":"BC Cancer Foundation","award_id":null},{"funder":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research","award_id":null},{"funder":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada","award_id":null}],"datasets":[],"versions":[],"referenced_works_count":50,"referenced_works":["https://openalex.org/W1140456871","https://openalex.org/W1987060944","https://openalex.org/W1992689348","https://openalex.org/W2028156849","https://openalex.org/W2030176606","https://openalex.org/W2052672777","https://openalex.org/W2137780330","https://openalex.org/W2171213649","https://openalex.org/W2517450409","https://openalex.org/W2560755587","https://openalex.org/W2586409664","https://openalex.org/W2586781596","https://openalex.org/W2606315875","https://openalex.org/W2767780867","https://openalex.org/W2782583667","https://openalex.org/W2937483840","https://openalex.org/W2947344342","https://openalex.org/W2969742213","https://openalex.org/W2998541769","https://openalex.org/W3004060585","https://openalex.org/W3004450349","https://openalex.org/W3020404241","https://openalex.org/W3028823371","https://openalex.org/W3033834557","https://openalex.org/W3034923725","https://openalex.org/W3035247457","https://openalex.org/W3049530212","https://openalex.org/W3094454392","https://openalex.org/W3098616265","https://openalex.org/W3106447063","https://openalex.org/W3110862590","https://openalex.org/W3121602482","https://openalex.org/W3164738465","https://openalex.org/W3170078776","https://openalex.org/W3176798788","https://openalex.org/W3178706301","https://openalex.org/W3203014445","https://openalex.org/W3203685240","https://openalex.org/W3211315061","https://openalex.org/W4200237746","https://openalex.org/W4214827779","https://openalex.org/W4220957539","https://openalex.org/W4221065215","https://openalex.org/W4224254270","https://openalex.org/W4283015563","https://openalex.org/W4283791949","https://openalex.org/W4285494961","https://openalex.org/W4311114659","https://openalex.org/W560810297","https://openalex.org/W781440871"],"related_works":["https://openalex.org/W3014051166","https://openalex.org/W2606465226","https://openalex.org/W2566797669","https://openalex.org/W2188373111","https://openalex.org/W2094296580","https://openalex.org/W2074598028","https://openalex.org/W2021992479","https://openalex.org/W2021210918","https://openalex.org/W1991573020","https://openalex.org/W113073308"],"abstract_inverted_index":null,"abstract_inverted_index_v3":null,"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W4390483972","counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5}],"updated_date":"2025-04-22T17:19:12.183705","created_date":"2024-01-02"}