{"id":"https://openalex.org/W4388799094","doi":"https://doi.org/10.1016/j.cmpb.2023.107929","title":"Phys-DAT: A physiologically-based pharmacokinetic model for unraveling the dissolution, transit and absorption processes using PhysPK\u00ae","display_name":"Phys-DAT: A physiologically-based pharmacokinetic model for unraveling the dissolution, transit and absorption processes using PhysPK\u00ae","publication_year":2023,"publication_date":"2023-11-17","ids":{"openalex":"https://openalex.org/W4388799094","doi":"https://doi.org/10.1016/j.cmpb.2023.107929","pmid":"https://pubmed.ncbi.nlm.nih.gov/38006685"},"language":"en","primary_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cmpb.2023.107929","pdf_url":null,"source":{"id":"https://openalex.org/S138959710","display_name":"Computer Methods and Programs in Biomedicine","issn_l":"0169-2607","issn":["0169-2607","1872-7565"],"is_oa":false,"is_in_doaj":false,"is_indexed_in_scopus":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},"type":"article","type_crossref":"journal-article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.cmpb.2023.107929","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004344581","display_name":"Marina Cuquerella-Gilabert","orcid":null},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]},{"id":"https://openalex.org/I4210134227","display_name":"Empresarios Agrupados","ror":"https://ror.org/04838xh83","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210134227"]},{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marina Cuquerella-Gilabert","raw_affiliation_strings":["Department of Pharmacy and Pharmaceutical Technology and Parasitology, University of Valencia, Valencia, Spain","Interuniversity Research Institute for Molecular Recognition and Technological Development, Polytechnic University of Valencia-University of Valencia, Valencia, Spain","Simulation Department, Empresarios Agrupados Internacional S.A., Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Pharmaceutical Technology and Parasitology, University of Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I16097986"]},{"raw_affiliation_string":"Simulation Department, Empresarios Agrupados Internacional S.A., Madrid, Spain","institution_ids":["https://openalex.org/I4210134227"]},{"raw_affiliation_string":"Interuniversity Research Institute for Molecular Recognition and Technological Development, Polytechnic University of Valencia-University of Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085851997","display_name":"Javier Reig-L\u00f3pez","orcid":"https://orcid.org/0000-0002-6007-3055"},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]},{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Javier Reig-L\u00f3pez","raw_affiliation_strings":["Department of Pharmacy and Pharmaceutical Technology and Parasitology, University of Valencia, Valencia, Spain","Interuniversity Research Institute for Molecular Recognition and Technological Development, Polytechnic University of Valencia-University of Valencia, Valencia, Spain"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Pharmaceutical Technology and Parasitology, University of Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I16097986"]},{"raw_affiliation_string":"Interuniversity Research Institute for Molecular Recognition and Technological Development, Polytechnic University of Valencia-University of Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029975398","display_name":"Jenifer Serna","orcid":null},"institutions":[{"id":"https://openalex.org/I4210134227","display_name":"Empresarios Agrupados","ror":"https://ror.org/04838xh83","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210134227"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jenifer Serna","raw_affiliation_strings":["Simulation Department, Empresarios Agrupados Internacional S.A., Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"Simulation Department, Empresarios Agrupados Internacional S.A., Madrid, Spain","institution_ids":["https://openalex.org/I4210134227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016065350","display_name":"Almudena Rueda-Ferreiro","orcid":null},"institutions":[{"id":"https://openalex.org/I4210134227","display_name":"Empresarios Agrupados","ror":"https://ror.org/04838xh83","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210134227"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Almudena Rueda-Ferreiro","raw_affiliation_strings":["Simulation Department, Empresarios Agrupados Internacional S.A., Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"Simulation Department, Empresarios Agrupados Internacional S.A., Madrid, Spain","institution_ids":["https://openalex.org/I4210134227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005690718","display_name":"Matilde Merino\u2010Sanju\u00e1n","orcid":"https://orcid.org/0000-0003-4956-0247"},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]},{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Matilde Merino-Sanjuan","raw_affiliation_strings":["Department of Pharmacy and Pharmaceutical Technology and Parasitology, University of Valencia, Valencia, Spain","Interuniversity Research Institute for Molecular Recognition and Technological Development, Polytechnic University of Valencia-University of Valencia, Valencia, Spain"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Pharmaceutical Technology and Parasitology, University of Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I16097986"]},{"raw_affiliation_string":"Interuniversity Research Institute for Molecular Recognition and Technological Development, Polytechnic University of Valencia-University of Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069976655","display_name":"V\u00edctor Mangas\u2010Sanju\u00e1n","orcid":"https://orcid.org/0000-0002-3388-5023"},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]},{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Victor Mangas-Sanjuan","raw_affiliation_strings":["Department of Pharmacy and Pharmaceutical Technology and Parasitology, University of Valencia, Valencia, Spain","Interuniversity Research Institute for Molecular Recognition and Technological Development, Polytechnic University of Valencia-University of Valencia, Valencia, Spain"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Pharmaceutical Technology and Parasitology, University of Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I16097986"]},{"raw_affiliation_string":"Interuniversity Research Institute for Molecular Recognition and Technological Development, Polytechnic University of Valencia-University of Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018371456","display_name":"Sergio S\u00e1nchez-Herrero","orcid":"https://orcid.org/0000-0002-5647-0330"},"institutions":[{"id":"https://openalex.org/I4210134227","display_name":"Empresarios Agrupados","ror":"https://ror.org/04838xh83","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210134227"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sergio S\u00e1nchez-Herrero","raw_affiliation_strings":["Simulation Department, Empresarios Agrupados Internacional S.A., Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"Simulation Department, Empresarios Agrupados Internacional S.A., Madrid, Spain","institution_ids":["https://openalex.org/I4210134227"]}]}],"institution_assertions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5069976655"],"corresponding_institution_ids":["https://openalex.org/I16097986","https://openalex.org/I60053951"],"apc_list":{"value":2880,"currency":"USD","value_usd":2880,"provenance":"doaj"},"apc_paid":{"value":2880,"currency":"USD","value_usd":2880,"provenance":"doaj"},"fwci":0.245,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.332568,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":67,"max":78},"biblio":{"volume":"243","issue":null,"first_page":"107929","last_page":"107929"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9999,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9999,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.9997,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.9995,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C185867374","wikidata":"https://www.wikidata.org/wiki/Q2562769","display_name":"Physiologically based pharmacokinetic modelling","level":3,"score":0.91459703},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.75050724},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.68094265},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.65909046},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.57308376},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.56964344},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5490964},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.50765336},{"id":"https://openalex.org/C88380143","wikidata":"https://www.wikidata.org/wiki/Q416674","display_name":"Dissolution","level":2,"score":0.49189234},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.38474846},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.3266118},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32571256},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.31301582},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.25164413},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.15690684},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10595751},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0755294},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D007408","descriptor_name":"Intestinal Absorption","qualifier_ui":"","qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":"","qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":"","qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cmpb.2023.107929","pdf_url":null,"source":{"id":"https://openalex.org/S138959710","display_name":"Computer Methods and Programs in Biomedicine","issn_l":"0169-2607","issn":["0169-2607","1872-7565"],"is_oa":false,"is_in_doaj":false,"is_indexed_in_scopus":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://hdl.handle.net/10550/97985","pdf_url":"https://roderic.uv.es/bitstreams/b3ec822f-9432-4f74-b2f9-f8947f81299a/download","source":{"id":"https://openalex.org/S4306400245","display_name":"Repository of Digital Objects for Teaching Research and Culture (University of Valencia)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_indexed_in_scopus":false,"is_core":false,"host_organization":"https://openalex.org/I16097986","host_organization_name":"Universitat de Val\u00e8ncia","host_organization_lineage":["https://openalex.org/I16097986"],"host_organization_lineage_names":["Universitat de Val\u00e8ncia"],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38006685","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_indexed_in_scopus":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cmpb.2023.107929","pdf_url":null,"source":{"id":"https://openalex.org/S138959710","display_name":"Computer Methods and Programs in Biomedicine","issn_l":"0169-2607","issn":["0169-2607","1872-7565"],"is_oa":false,"is_in_doaj":false,"is_indexed_in_scopus":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},"sustainable_development_goals":[],"grants":[{"funder":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","award_id":null}],"datasets":[],"versions":[],"referenced_works_count":22,"referenced_works":["https://openalex.org/W1592313382","https://openalex.org/W2026627938","https://openalex.org/W2062761938","https://openalex.org/W2084869707","https://openalex.org/W2085441754","https://openalex.org/W2086507424","https://openalex.org/W2092137244","https://openalex.org/W2127990344","https://openalex.org/W2143548516","https://openalex.org/W2162099840","https://openalex.org/W2328022676","https://openalex.org/W2719020302","https://openalex.org/W2763609521","https://openalex.org/W2941142930","https://openalex.org/W2991259971","https://openalex.org/W3000017105","https://openalex.org/W3008423797","https://openalex.org/W4224295384","https://openalex.org/W4280544609","https://openalex.org/W4280580004","https://openalex.org/W4280615159","https://openalex.org/W4297474534"],"related_works":["https://openalex.org/W4362719415","https://openalex.org/W4297964896","https://openalex.org/W4280586381","https://openalex.org/W325264682","https://openalex.org/W3111369148","https://openalex.org/W2909814037","https://openalex.org/W2766249071","https://openalex.org/W2425400028","https://openalex.org/W2401279245","https://openalex.org/W2091436125"],"abstract_inverted_index":{"In":[0],"silico":[1,177],"methods":[2],"have":[3],"become":[4],"the":[5,16,19,36,47,68,75,79,103,121,151,158,219,223,265,277,298,306,310,324,328,331],"key":[6],"for":[7,120,204,234,272,313],"efficiently":[8],"testing":[9],"and":[10,22,63,71,98,114,133,138,178,185,191,207,214,226,231,238,250,282,305],"qualifying":[11],"drug":[12,23,28,122],"properties.":[13],"Due":[14],"to":[15,26,54,73,149,288,297,326],"complexity":[17],"of":[18,38,49,60,78,102,157,182,201,330],"LADME":[20],"processes":[21,66,125],"characteristics":[24],"associated":[25],"oral":[27,274,314],"absorption,":[29,275],"there":[30],"is":[31],"a":[32,56,269,290],"growing":[33],"demand":[34],"in":[35,67,84,176,179,320],"development":[37],"Physiologically-based":[39],"Pharmacokinetic":[40],"(PBPK)":[41],"software":[42],"with":[43,222,260,292,309,335],"greater":[44],"flexibility.":[45],"Thus,":[46],"aims":[48],"this":[50],"work":[51],"are":[52],"(i)":[53],"develop":[55],"mechanistic-based":[57],"modeling":[58,337],"framework":[59],"dissolution,":[61,278],"transit":[62,116,137],"absorption":[64,140,145,283],"(Phys-DAT)":[65],"PhysPK":[69,285],"platform":[70],"(ii)":[72],"assess":[74],"predictive":[76,258,318],"power":[77],"acausal":[80,332],"MOOM":[81,333],"methodology":[82,334],"embedded":[83],"Phys-DAT":[85,159,311],"versus":[86],"reference":[87,303],"ODE-based":[88,301],"PBPK":[89,91,302],"software.A":[90],"model":[92,160,197,220,271,312],"was":[93,109,118,161,172],"developed":[94],"including":[95,142,276],"unreleased,":[96],"undissolved":[97],"dissolved":[99],"thermodynamic":[100],"states":[101],"drug.":[104],"The":[105],"gastrointestinal":[106],"tract":[107],"(GI)":[108],"represented":[110],"by":[111,300],"nine":[112],"compartments":[113],"first-order":[115],"kinetics":[117],"assumed":[119],"fractions.":[123],"Dissolution":[124],"were":[126,147,195],"described":[127],"using":[128,175,210],"solubility-independent":[129],"or":[130],"solubility-dependent":[131],"mechanisms":[132,141],"pH":[134,279],"effects.":[135],"Linear":[136],"linear":[139],"gradual":[143],"decrease":[144],"rate":[146],"considered":[148],"represent":[150],"passive":[152],"diffusion":[153],"process.":[154],"Internal":[155,213],"validation":[156,171],"performed":[162],"through":[163],"simulation-based":[164],"analysis,":[165],"considering":[166],"different":[167],"theoretical":[168,224],"scenarios.":[169],"External":[170],"carried":[173],"out":[174],"vivo":[180],"data":[181],"GI":[183],"segments":[184],"plasma":[186],"concentrations.":[187],"Both":[188],"BCS":[189,236],"I":[190,237],"II":[192,239],"class":[193],"drugs":[194,316],"included.The":[196],"predicts":[198],"plasma-concentration":[199],"profiles":[200],"each":[202],"compartment":[203],"undissolved,":[205],"dissolved,":[206],"absorbed":[208],"fractions":[209],"PhysPK\u00ae":[211],"v.2.4.1.":[212],"external":[215],"validations":[216],"demonstrate":[217],"that":[218],"aligned":[221],"assumptions":[225],"accurately":[227],"predicted":[228],"Cmax,":[229],"Tmax,":[230],"AUC":[232],"0-t":[233],"both":[235],"drugs.":[240],"Average":[241,246],"Fold":[242,247],"Error":[243,248,253],"(AFE),":[244],"Absolute":[245],"(AAFE),":[249],"Percent":[251],"Prediction":[252],"(PPE)":[254],"calculations":[255],"indicate":[256],"good":[257],"performance,":[259],"predicted/observed":[261],"ratios":[262],"falling":[263],"within":[264],"acceptable":[266],"range.Phys-DAT":[267],"represents":[268],"mechanistic":[270],"predicting":[273],"effect,":[280],"transit,":[281],"processes.":[284],"has":[286],"shown":[287],"be":[289],"tool":[291],"strong":[293],"prediction":[294],"accuracy,":[295],"similar":[296],"obtained":[299,308],"software,":[304],"results":[307],"administered":[315],"showed":[317],"reliability":[319],"healthy":[321],"volunteers,":[322],"setting":[323],"basis":[325],"determine":[327],"interchangeability":[329],"other":[336],"approaches.":[338]},"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W4388799094","counts_by_year":[],"updated_date":"2025-01-23T03:41:14.769737","created_date":"2023-11-19"}