{"id":"https://openalex.org/W2337129827","doi":"https://doi.org/10.1007/s40708-016-0041-7","title":"Reconstructing the brain: from image stacks to neuron synthesis","display_name":"Reconstructing the brain: from image stacks to neuron synthesis","publication_year":2016,"publication_date":"2016-02-24","ids":{"openalex":"https://openalex.org/W2337129827","doi":"https://doi.org/10.1007/s40708-016-0041-7","mag":"2337129827","pmid":"https://pubmed.ncbi.nlm.nih.gov/27747813","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5106405"},"language":"en","primary_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40708-016-0041-7","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs40708-016-0041-7.pdf","source":{"id":"https://openalex.org/S2498492389","display_name":"Brain Informatics","issn_l":"2198-4026","issn":["2198-4026","2198-4018"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319965","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Springer Nature","Springer Science+Business Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},"type":"article","type_crossref":"journal-article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1007%2Fs40708-016-0041-7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049541847","display_name":"Julian C. Shillcock","orcid":"https://orcid.org/0000-0002-7885-735X"},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Julian C. Shillcock","raw_affiliation_strings":["Blue Brain Project, EPFL, 1211, Geneva, Switzerland"],"affiliations":[{"raw_affiliation_string":"Blue Brain Project, EPFL, 1211, Geneva, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090586758","display_name":"Michael Hawrylycz","orcid":"https://orcid.org/0000-0002-5741-8024"},"institutions":[{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I1314596251","display_name":"Allen Institute for Brain Science","ror":"https://ror.org/00dcv1019","country_code":"US","type":"facility","lineage":["https://openalex.org/I1314596251","https://openalex.org/I4210140341"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Hawrylycz","raw_affiliation_strings":["Allen Institute for Brain Science, Seattle, WA, 98109, USA"],"affiliations":[{"raw_affiliation_string":"Allen Institute for Brain Science, Seattle, WA, 98109, USA","institution_ids":["https://openalex.org/I4210140341","https://openalex.org/I1314596251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048268124","display_name":"Sean Hill","orcid":"https://orcid.org/0000-0001-8055-860X"},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Sean Hill","raw_affiliation_strings":["Blue Brain Project, EPFL, 1211, Geneva, Switzerland"],"affiliations":[{"raw_affiliation_string":"Blue Brain Project, EPFL, 1211, Geneva, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036224886","display_name":"Hanchuan Peng","orcid":"https://orcid.org/0000-0002-3478-3942"},"institutions":[{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I1314596251","display_name":"Allen Institute for Brain Science","ror":"https://ror.org/00dcv1019","country_code":"US","type":"facility","lineage":["https://openalex.org/I1314596251","https://openalex.org/I4210140341"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hanchuan Peng","raw_affiliation_strings":["Allen Institute for Brain Science, Seattle, WA, 98109, USA"],"affiliations":[{"raw_affiliation_string":"Allen Institute for Brain Science, Seattle, WA, 98109, USA","institution_ids":["https://openalex.org/I4210140341","https://openalex.org/I1314596251"]}]}],"institution_assertions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":790,"currency":"GBP","value_usd":969,"provenance":"doaj"},"apc_paid":{"value":790,"currency":"GBP","value_usd":969,"provenance":"doaj"},"fwci":0.758,"has_fulltext":true,"fulltext_origin":"ngrams","cited_by_count":9,"citation_normalized_percentile":{"value":0.794799,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":85,"max":86},"biblio":{"volume":"3","issue":"4","first_page":"205","last_page":"209"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9999,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9999,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9889,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9742,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuronal-morphology","display_name":"Neuronal Morphology","score":0.500894},{"id":"https://openalex.org/keywords/brain-atlas","display_name":"Brain atlas","score":0.47242343}],"concepts":[{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.84489286},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6967989},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.4724895},{"id":"https://openalex.org/C2780972224","wikidata":"https://www.wikidata.org/wiki/Q17047956","display_name":"Brain atlas","level":2,"score":0.47242343},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.44827744},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.41657135},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.38312593},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13885027},{"id":"https://openalex.org/C58640448","wikidata":"https://www.wikidata.org/wiki/Q42515","display_name":"Cartography","level":1,"score":0.11566618},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.10247141},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40708-016-0041-7","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs40708-016-0041-7.pdf","source":{"id":"https://openalex.org/S2498492389","display_name":"Brain Informatics","issn_l":"2198-4026","issn":["2198-4026","2198-4018"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319965","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Springer Nature","Springer Science+Business Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106405","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27747813","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40708-016-0041-7","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs40708-016-0041-7.pdf","source":{"id":"https://openalex.org/S2498492389","display_name":"Brain Informatics","issn_l":"2198-4026","issn":["2198-4026","2198-4018"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319965","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Springer Nature","Springer Science+Business Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/8","display_name":"Decent work and economic growth","score":0.44}],"grants":[],"datasets":[],"versions":[],"referenced_works_count":16,"referenced_works":["https://openalex.org/W1508135620","https://openalex.org/W1921182138","https://openalex.org/W1965210407","https://openalex.org/W1971689790","https://openalex.org/W1974049455","https://openalex.org/W1989396876","https://openalex.org/W1995031373","https://openalex.org/W2018227909","https://openalex.org/W2019305522","https://openalex.org/W2025603247","https://openalex.org/W2066381178","https://openalex.org/W2074633779","https://openalex.org/W2102667107","https://openalex.org/W2112745564","https://openalex.org/W2171895829","https://openalex.org/W2178605380"],"related_works":["https://openalex.org/W45233828","https://openalex.org/W4255934811","https://openalex.org/W2964988449","https://openalex.org/W2465382974","https://openalex.org/W2397952901","https://openalex.org/W2182707996","https://openalex.org/W2029380707","https://openalex.org/W2010229520","https://openalex.org/W1981780420","https://openalex.org/W188202134"],"abstract_inverted_index":{"Large-scale":[0],"brain":[1],"initiatives":[2],"such":[3],"as":[4],"the":[5,10,26,52,134],"US":[6],"BRAIN":[7],"initiative":[8,73],"and":[9,23,46,85,138],"European":[11],"Human":[12],"Brain":[13],"Project":[14],"aim":[15],"to":[16,35,51,60,88,105,110,133],"marshall":[17],"a":[18,99,140],"vast":[19],"amount":[20],"of":[21,28,32,65,93,102,115,127,142],"data":[22,108],"tools":[24],"for":[25],"purpose":[27],"furthering":[29],"our":[30],"understanding":[31],"brains.":[33],"Fundamental":[34],"this":[36,63,103,107],"goal":[37],"is":[38,68,74,86],"that":[39],"neuronal":[40],"morphologies":[41,67],"must":[42],"be":[43],"seamlessly":[44],"reconstructed":[45,95,128],"aggregated":[47],"on":[48],"scales":[49],"up":[50],"whole":[53],"rodent":[54],"brain.":[55],"The":[56,71],"experimental":[57],"labor":[58],"needed":[59],"manually":[61],"produce":[62],"number":[64,114],"digital":[66,120,131],"prohibitively":[69],"large.":[70],"BigNeuron":[72],"assembling":[75],"community-generated,":[76],"open-source,":[77],"automated":[78,125],"reconstruction":[79],"algorithms":[80],"into":[81,130],"an":[82,90,112],"open":[83],"platform,":[84],"beginning":[87],"generate":[89,111],"increasing":[91],"flow":[92],"high-quality":[94],"neurons.":[96],"We":[97],"propose":[98],"novel":[100],"extension":[101],"workflow":[104],"use":[106],"stream":[109],"unlimited":[113],"statistically":[116],"equivalent,":[117],"yet":[118],"distinct,":[119],"morphologies.":[121],"This":[122],"will":[123],"bring":[124],"processing":[126],"cells":[129],"neurons":[132],"wider":[135],"neuroscience":[136],"community,":[137],"enable":[139],"range":[141],"morphologically":[143],"accurate":[144],"computational":[145],"models.":[146]},"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W2337129827","counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2024-12-05T06:57:24.100259","created_date":"2016-06-24"}