{"id":"https://openalex.org/W2080019421","doi":"https://doi.org/10.1007/s11517-008-0381-4","title":"Biomechanical analysis of structural deformation in living cells","display_name":"Biomechanical analysis of structural deformation in living cells","publication_year":2008,"publication_date":"2008-08-25","ids":{"openalex":"https://openalex.org/W2080019421","doi":"https://doi.org/10.1007/s11517-008-0381-4","mag":"2080019421","pmid":"https://pubmed.ncbi.nlm.nih.gov/18726630"},"language":"en","primary_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11517-008-0381-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11517-008-0381-4.pdf","source":{"id":"https://openalex.org/S46300952","display_name":"Medical & Biological Engineering & Computing","issn_l":"0140-0118","issn":["0140-0118","1741-0444"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319965","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Springer Nature","Springer Science+Business Media"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true},"type":"review","type_crossref":"journal-article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s11517-008-0381-4.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067793114","display_name":"Dan L. Bader","orcid":"https://orcid.org/0000-0002-1208-3507"},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dan L. Bader","raw_affiliation_strings":["School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London, UK,"],"affiliations":[{"raw_affiliation_string":"School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London, UK,","institution_ids":["https://openalex.org/I166337079"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027557364","display_name":"Martin M. Knight","orcid":"https://orcid.org/0000-0003-3755-1597"},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Martin M. Knight","raw_affiliation_strings":["School of engineering and Materials Science, Queen Mary University of London, London, UK"],"affiliations":[{"raw_affiliation_string":"School of engineering and Materials Science, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079"]}]}],"institution_assertions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2890,"currency":"EUR","value_usd":3690,"provenance":"doaj"},"apc_paid":{"value":2890,"currency":"EUR","value_usd":3690,"provenance":"doaj"},"fwci":0.204,"has_fulltext":true,"fulltext_origin":"pdf","cited_by_count":39,"citation_normalized_percentile":{"value":0.422517,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":93},"biblio":{"volume":"46","issue":"10","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9998,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9998,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9975,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.994,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"Mechanotransduction","score":0.80628264},{"id":"https://openalex.org/keywords/cell-type","display_name":"Cell type","score":0.47085255},{"id":"https://openalex.org/keywords/human-physiology","display_name":"Human physiology","score":0.41959128},{"id":"https://openalex.org/keywords/mechanobiology","display_name":"mechanobiology","score":0.41410893}],"concepts":[{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.80628264},{"id":"https://openalex.org/C204366326","wikidata":"https://www.wikidata.org/wiki/Q3027650","display_name":"Deformation (meteorology)","level":2,"score":0.6208407},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6154357},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.54725873},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.48157907},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.47085255},{"id":"https://openalex.org/C2986265897","wikidata":"https://www.wikidata.org/wiki/Q23852","display_name":"Human physiology","level":2,"score":0.41959128},{"id":"https://openalex.org/C2780171871","wikidata":"https://www.wikidata.org/wiki/Q6804676","display_name":"Mechanobiology","level":2,"score":0.41410893},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.32096618},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30038935},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.09317163},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08361673},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":"","qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11517-008-0381-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11517-008-0381-4.pdf","source":{"id":"https://openalex.org/S46300952","display_name":"Medical & Biological Engineering & Computing","issn_l":"0140-0118","issn":["0140-0118","1741-0444"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319965","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Springer Nature","Springer Science+Business Media"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://eprints.soton.ac.uk/169053/1/bader_and_knight_2008.pdf","pdf_url":"https://eprints.soton.ac.uk/169053/1/bader_and_knight_2008.pdf","source":{"id":"https://openalex.org/S4306401020","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":["University of Southampton"],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false},{"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18726630","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11517-008-0381-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11517-008-0381-4.pdf","source":{"id":"https://openalex.org/S46300952","display_name":"Medical & Biological Engineering & Computing","issn_l":"0140-0118","issn":["0140-0118","1741-0444"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319965","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Springer Nature","Springer Science+Business Media"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true},"sustainable_development_goals":[],"grants":[],"datasets":[],"versions":[],"referenced_works_count":88,"referenced_works":["https://openalex.org/W1514271154","https://openalex.org/W1756833589","https://openalex.org/W1806136371","https://openalex.org/W1836626701","https://openalex.org/W1936770188","https://openalex.org/W1939884288","https://openalex.org/W1953513934","https://openalex.org/W1963915666","https://openalex.org/W1964284160","https://openalex.org/W1972152068","https://openalex.org/W1973343064","https://openalex.org/W1973825109","https://openalex.org/W1974433521","https://openalex.org/W1974489896","https://openalex.org/W1974541126","https://openalex.org/W1984096144","https://openalex.org/W1987188142","https://openalex.org/W1987835038","https://openalex.org/W1989693137","https://openalex.org/W1992632363","https://openalex.org/W1997614695","https://openalex.org/W1999344049","https://openalex.org/W2005568854","https://openalex.org/W2009350275","https://openalex.org/W2013453913","https://openalex.org/W2013674234","https://openalex.org/W2014741097","https://openalex.org/W2024197417","https://openalex.org/W2025245313","https://openalex.org/W2028920277","https://openalex.org/W2031967418","https://openalex.org/W2033600175","https://openalex.org/W2033620253","https://openalex.org/W2041126017","https://openalex.org/W2041438585","https://openalex.org/W2043380798","https://openalex.org/W2045497567","https://openalex.org/W2051877055","https://openalex.org/W2052391231","https://openalex.org/W2053079917","https://openalex.org/W2053117566","https://openalex.org/W2054388804","https://openalex.org/W2055612825","https://openalex.org/W2058396041","https://openalex.org/W2060177572","https://openalex.org/W2064604380","https://openalex.org/W2068062803","https://openalex.org/W2070294327","https://openalex.org/W2071720513","https://openalex.org/W2072526028","https://openalex.org/W2073392353","https://openalex.org/W2073944831","https://openalex.org/W2077517220","https://openalex.org/W2080695242","https://openalex.org/W2081312806","https://openalex.org/W2081639760","https://openalex.org/W2083229732","https://openalex.org/W2092857221","https://openalex.org/W2095957743","https://openalex.org/W2111506638","https://openalex.org/W2117359999","https://openalex.org/W2121652300","https://openalex.org/W2124745785","https://openalex.org/W2127896920","https://openalex.org/W2130851152","https://openalex.org/W2131456542","https://openalex.org/W2131999768","https://openalex.org/W2134449918","https://openalex.org/W2137408320","https://openalex.org/W2138402450","https://openalex.org/W2139020009","https://openalex.org/W2142863267","https://openalex.org/W2143873872","https://openalex.org/W2143876847","https://openalex.org/W2153541683","https://openalex.org/W2155236360","https://openalex.org/W2158200659","https://openalex.org/W2160816643","https://openalex.org/W2161302310","https://openalex.org/W2166647329","https://openalex.org/W2171462465","https://openalex.org/W2171577674","https://openalex.org/W2225382385","https://openalex.org/W2419291131","https://openalex.org/W2440339354","https://openalex.org/W4244270736","https://openalex.org/W59217392","https://openalex.org/W75644737"],"related_works":["https://openalex.org/W4386143410","https://openalex.org/W3108722944","https://openalex.org/W2957203663","https://openalex.org/W2560559234","https://openalex.org/W2414307100","https://openalex.org/W2102661335","https://openalex.org/W2097785340","https://openalex.org/W2048409757","https://openalex.org/W1990851605","https://openalex.org/W1970570245"],"abstract_inverted_index":{"Most":[0],"tissues":[1],"are":[2],"subject":[3],"to":[4,24,48,55,60],"some":[5],"form":[6],"of":[7,15,32,53,107,126,134],"physiological":[8],"mechanical":[9],"loading":[10,25,56,73,99],"which":[11,101],"results":[12],"in":[13,41,84,90],"deformation":[14,38,82,125],"the":[16,30,33,50,71,114],"cells":[17,54,63,144],"triggering":[18],"intracellular":[19,65],"mechanotransduction":[20],"pathways.":[21],"This":[22,68],"response":[23,52],"is":[26,58],"generally":[27],"essential":[28],"for":[29,79],"health":[31],"tissue,":[34],"although":[35],"more":[36],"pronounced":[37],"may":[39],"result":[40],"cell":[42,81,92,108,136],"and":[43,64,89,104,117,145,147],"tissue":[44,87],"damage.":[45],"In":[46,95],"order":[47],"determine":[49],"biological":[51],"it":[57,97],"necessary":[59],"understand":[61],"how":[62],"structures":[66],"deform.":[67],"paper":[69],"reviews":[70],"various":[72],"systems":[74,100],"that":[75],"have":[76],"been":[77],"adopted":[78],"studying":[80],"both":[83],"situ":[85],"within":[86],"explants":[88],"isolated":[91],"culture":[93],"systems.":[94],"particular":[96],"describes":[98,113],"facilitate":[102],"visualisation":[103],"subsequent":[105],"quantification":[106],"deformation.":[109],"The":[110,121],"review":[111,122],"also":[112],"associated":[115],"microscopy":[116],"image":[118],"analysis":[119],"techniques.":[120],"focuses":[123],"on":[124,131],"chondrocytes":[127],"with":[128],"additional":[129],"information":[130],"a":[132],"variety":[133],"other":[135],"types":[137],"including":[138],"neurons,":[139],"red":[140],"blood":[141],"cells,":[142],"epithelial":[143],"skin":[146],"muscle":[148],"cells.":[149]},"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W2080019421","counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2025-01-05T09:36:58.806089","created_date":"2016-06-24"}