Identification of protein interaction network is very important to find the cell signaling pathway for a particular disease. The authors have found the differentially expressed genes between two sample groups of HIV-1. Samples are wild type HIV-1 Vpr and HIV-1 mutant Vpr. They did statistical t-test and found false discovery rate (FDR) to identify the genes increased in expression (up-regulated) or decreased in expression (down-regulated). In the test, the authors have computed q-values of test to identify minimum FDR which occurs. As a result they found 172 differentially expressed genes between their sample wild type HIV-1 Vpr and HIV-1 mutant Vpr, R80A. They found 68 up-regulated genes and 104 down-regulated genes. From the 172 differentially expressed genes the authors found protein-protein interaction network with string-db and then clustered (subnetworks) the PPI networks with cytoscape3.0. Lastly, the authors studied significance of subnetworks with performing gene ontology and also studied the KEGG pathway of those subnetworks.<\/p>","DOI":"10.4018\/ijsda.2015100103","type":"journal-article","created":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T18:07:05Z","timestamp":1441130825000},"page":"35-51","source":"Crossref","is-referenced-by-count":1,"title":["Extracting Biological Significant Subnetworks from Protein-Protein Interactions Induced by Differentially Expressed Genes of HIV-1 Vpr Variants"],"prefix":"10.4018","volume":"4","author":[{"given":"Bandana","family":"Barman","sequence":"first","affiliation":[{"name":"Department of Electronics and Communication Engineering, Kalyani Government Engineering College, Kalyani, India"}]},{"given":"Anirban","family":"Mukhopadhyay","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, University of Kalyani, Kalyani, India"}]}],"member":"2432","container-title":["International Journal of System Dynamics Applications"],"original-title":[],"language":"ng","link":[{"URL":"https:\/\/www.igi-global.com\/viewtitle.aspx?TitleId=136997","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T00:14:32Z","timestamp":1654128872000},"score":1,"resource":{"primary":{"URL":"https:\/\/services.igi-global.com\/resolvedoi\/resolve.aspx?doi=10.4018\/IJSDA.2015100103"}},"subtitle":[""],"short-title":[],"issued":{"date-parts":[[2015,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,10]]}},"URL":"https:\/\/doi.org\/10.4018\/ijsda.2015100103","relation":{},"ISSN":["2160-9772","2160-9799"],"issn-type":[{"value":"2160-9772","type":"print"},{"value":"2160-9799","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,1]]}}}