{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T19:40:36Z","timestamp":1722714036800},"reference-count":86,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Systems"],"abstract":"The Brainport-Eindhoven region has developed into a leading location for deeptech entrepreneurship in Europe. Against all odds, it has transformed itself from a region that heavily depended on the multinational company Philips, into a diverse and fast-growing deeptech ecosystem. While this success has not gone unnoticed, there is not yet a clear account of how and why the Eindhoven region emerged as a global hotspot for deeptech innovation and entrepreneurship. Moreover, such an account might provide an exemplary model of a collaborative ecosystem, one that provides an alternative to the \u201cwinner-takes-all\u201d entrepreneurial culture of Silicon Valley. This essay explores the performance of the Eindhoven region in terms of three structural conditions. First, the focus on deeptech R&D and entrepreneurship appears to be deeply rooted in the region\u2019s history as well as strong competencies in systems engineering, design thinking, and multidisciplinary collaboration. Second, a collaborative approach to regional policy gives industrial, academic, and governmental actors an equivalent position in its \u201ctriple helix\u201d governance. Finally, the Eindhoven region benefits from a systemic approach toward co-locating R&D and entrepreneurial activities on five campuses. Overall, the huge complexity of deeptech systems and products apparently requires a truly collaborative approach at all levels of the entrepreneurial ecosystem.<\/jats:p>","DOI":"10.3390\/systems10040119","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T13:47:06Z","timestamp":1660139226000},"page":"119","source":"Crossref","is-referenced-by-count":5,"title":["Against All Odds: How Eindhoven Emerged as a Deeptech Ecosystem"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"http:\/\/orcid.org\/0000-0002-3997-1192","authenticated-orcid":false,"given":"A. Georges L.","family":"Romme","sequence":"first","affiliation":[{"name":"Industrial Engineering & Innovation Sciences Department, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,10]]},"reference":[{"key":"ref_1","unstructured":"Akhtar, O. (2021, February 25). 7 Best New Global Cities for Startups. Fortune, Available online: http:\/\/fortune.com\/2012\/09\/19\/7-best-new-global-cities-for-startups\/."},{"key":"ref_2","unstructured":"Pentland, W. (2021, March 04). World\u2019s 15 Most Inventive Cities. Forbes, Available online: http:\/\/www.forbes.com\/sites\/williampentland\/2013\/07\/09\/worlds-15-most-inventive-cities."},{"key":"ref_3","unstructured":"Statistics Netherlands (2022, June 03). Domestic R&D Expenditure over \u20ac18 Billion in 2020. Available online: https:\/\/www.cbs.nl\/en-gb\/news\/2022\/05\/domestic-r-d-expenditure-over-18-billion-in-2020."},{"key":"ref_4","unstructured":"Van Agtmael, A., and Bakker, F. (2016). 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