{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T16:40:11Z","timestamp":1740156011535,"version":"3.37.3"},"reference-count":28,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T00:00:00Z","timestamp":1543795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860632"],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Yunnan Applied Basic Research Projects-Union Foundation","award":["2017FE468 (-172), 2017FE468 (-022)"]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Symmetry"],"abstract":"(R)-6-Acrylic-BINOL CSP, a novel chiral stationary phase was prepared by (R)-Binaphthol (R-BINOL) by introducing the acrylic group into the 6-position of (R)-BINOL before bonding it to the surface of silica gel. The structure of the CSP was characterized by IR, SEM, and element analysis. This new material was tested for its potential as a CSP for HPLC under normal phase conditions, especially for conjugated compounds. Six solutes were chosen to evaluate the chiral separation ability of the novel CSP. The effects of the mobile phase and temperature on enantioseparation were studied, and the chiral recognition mechanism was also discussed. The results showed that the space adaptability and \u03c0-\u03c0 stacking between the solutes and the CSP affected the retention and enantioseparation. The Van\u2019t Hoff curve indicated that under the experimental conditions, the separation mechanism of six solutes did not change, which were all enthalpy driven.<\/jats:p>","DOI":"10.3390\/sym10120704","type":"journal-article","created":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T11:02:09Z","timestamp":1543834929000},"page":"704","source":"Crossref","is-referenced-by-count":7,"title":["Synthesis of a Novel Chiral Stationary Phase by (R)-1,1\u2032-Binaphthol and the Study on Mechanism of Chiral Recognition"],"prefix":"10.3390","volume":"10","author":[{"given":"Yongxi","family":"Wang","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China"},{"name":"Walvax Biotechnology Co., Ltd., Dingyi Tiancheng Residential Quarter, Kunming 650500, China"}]},{"given":"Dandan","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China"}]},{"given":"Yili","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China"}]},{"given":"Yanmei","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Yunnan College of Business Management, Kunming 650106, China"}]},{"given":"Jingfeng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medicinal Chemistry for Natural Resource, Yunnan University, Ministry of Education, Yunnan University, Kunming 650091, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5340-623X","authenticated-orcid":false,"given":"Baochun","family":"Shen","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China"}]}],"member":"1968","published-online":{"date-parts":[[2018,12,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.chroma.2016.05.061","article-title":"Chiral recognition in separation science\u2014An update","volume":"1467","author":"Scriba","year":"2016","journal-title":"J. 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