{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:21:15Z","timestamp":1723076475556},"reference-count":44,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"Neurofeedback (NF) is a promising intervention for improvements in motor performance in Parkinson\u2019s disease. This NF pilot study in healthy participants aimed to achieve the following: (1) determine participants\u2019 ability to bi-directionally modulate sensorimotor beta power and (2) determine the effect of NF on movement performance. A real-time EEG-NF protocol was used to train participants to increase and decrease their individual motor cortex beta power amplitude, using a within-subject double-blind sham-controlled approach. Movement was assessed using a Go\/No-go task. Participants completed the NASA Task Load Index and provided verbal feedback of the NF task difficulty. All 17 participants (median age = 38 (19\u201365); 10 females) reliably reduced sensorimotor beta power. No participant could reliably increase their beta activity. Participants reported that the NF task was challenging, particularly increasing beta. A modest but significant increase in reaction time correlated with a reduction in beta power only in the real condition. Findings suggest that beta power control difficulty varies by modulation direction, affecting participant perceptions. A correlation between beta power reduction and reaction times only in the real condition suggests that intentional beta power reduction may shorten reaction times. Future research should examine the minimum beta threshold for meaningful motor improvements, and the relationship between EEG mechanisms and NF learning to optimise NF outcomes.<\/jats:p>","DOI":"10.3390\/s24165107","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T12:42:28Z","timestamp":1723034548000},"page":"5107","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Feasibility of Bidirectional Control of Beta Oscillatory Power in Healthy Controls as a Potential Intervention for Parkinson\u2019s Disease Movement Impairment"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"http:\/\/orcid.org\/0000-0002-8027-1665","authenticated-orcid":false,"given":"Krithika","family":"Anil","sequence":"first","affiliation":[{"name":"School of Health Professions, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK"},{"name":"Brain Research and Imaging Centre, Faculty of Health, University of Plymouth, Research Way, Plymouth PL6 8BU, UK"}]},{"given":"Giorgio","family":"Ganis","sequence":"additional","affiliation":[{"name":"Brain Research and Imaging Centre, Faculty of Health, University of Plymouth, Research Way, Plymouth PL6 8BU, UK"},{"name":"School of Psychology, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK"}]},{"ORCID":"http:\/\/orcid.org\/0000-0002-4072-9758","authenticated-orcid":false,"given":"Jennifer A.","family":"Freeman","sequence":"additional","affiliation":[{"name":"Peninsula Allied Health Centre, School of Health Professions, University of Plymouth, Derriford Road, Plymouth PL6 8BH, UK"}]},{"given":"Jonathan","family":"Marsden","sequence":"additional","affiliation":[{"name":"School of Health Professions, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK"},{"name":"Brain Research and Imaging Centre, Faculty of Health, University of Plymouth, Research Way, Plymouth PL6 8BU, UK"}]},{"given":"Stephen D.","family":"Hall","sequence":"additional","affiliation":[{"name":"Brain Research and Imaging Centre, Faculty of Health, University of Plymouth, Research Way, Plymouth PL6 8BU, UK"},{"name":"School of Psychology, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s00702-017-1686-y","article-title":"Epidemiology of Parkinson\u2019s disease","volume":"124","author":"Tysnes","year":"2017","journal-title":"J. Neural Transm."},{"key":"ref_2","first-page":"701","article-title":"Short review on dopamine agonists: Insight into clinical and research studies relevant to Parkinson\u2019s disease","volume":"57","author":"Radad","year":"2005","journal-title":"Pharmacol. Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1523\/JNEUROSCI.2113-19.2020","article-title":"Parkinsonian Beta Dynamics during Rest and Movement in the Dorsal Pallidum and Subthalamic Nucleus","volume":"40","author":"Eisinger","year":"2020","journal-title":"J. Neurosci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1093\/brain\/awh480","article-title":"Cortico-cortical coupling in Parkinson\u2019s disease and its modulation by therapy","volume":"128","author":"Silberstein","year":"2005","journal-title":"Brain"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Eusebio, A., Cagnan, H., and Brown, P. (2012). Does suppression of oscillatory synchronisation mediate some of the therapeutic effects of DBS in patients with Parkinson\u2019s disease?. Front. Integr. Neurosci., 6.","DOI":"10.3389\/fnint.2012.00047"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1093\/brain\/awh715","article-title":"Modulation of beta oscillations in the subthalamic area during motor imagery in Parkinson\u2019s disease","volume":"129","author":"Doyle","year":"2006","journal-title":"Brain"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1001\/archneurol.2010.260","article-title":"Deep brain stimulation for Parkinson disease: An expert consensus and review of key issues","volume":"68","author":"Bronstein","year":"2011","journal-title":"Arch. Neurol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/s41582-019-0145-9","article-title":"Long-term outcomes of deep brain stimulation in Parkinson disease","volume":"15","author":"Limousin","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.conb.2007.12.001","article-title":"Abnormal oscillatory synchronisation in the motor system leads to impaired movement","volume":"17","author":"Brown","year":"2007","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"16095","DOI":"10.1073\/pnas.1819975116","article-title":"Temporal evolution of beta bursts in the parkinsonian cortical and basal ganglia network","volume":"116","author":"Cagnan","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.neuroscience.2014.09.037","article-title":"GABA-mediated changes in inter-hemispheric beta frequency activity in early-stage Parkinson\u2019s disease","volume":"281","author":"Hall","year":"2014","journal-title":"Neuroscience"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Prokic, E.J., Stanford, I.M., Woodhall, G.L., Williams, A.C., and Hall, S.D. (2019). Bradykinesia Is Driven by Cumulative Beta Power During Continuous Movement and Alleviated by Gabaergic Modulation in Parkinson\u2019s Disease. Front. Neurol., 10.","DOI":"10.3389\/fneur.2019.01298"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1093\/cercor\/bht121","article-title":"Neuromagnetic evidence of abnormal movement-related beta desynchronization in Parkinson\u2019s disease","volume":"24","author":"Wilson","year":"2014","journal-title":"Cereb. Cortex"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/0013-4694(89)90250-2","article-title":"Patterns of cortical activation during planning of voluntary movement","volume":"72","author":"Pfurtscheller","year":"1989","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1016\/j.neuroimage.2011.02.025","article-title":"The role of GABAergic modulation in motor function related neuronal network activity","volume":"56","author":"Hall","year":"2011","journal-title":"Neuroimage"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0167-8760(96)00066-9","article-title":"Event-related synchronization (ERS) in the alpha band\u2014An electrophysiological correlate of cortical idling: A review","volume":"24","author":"Pfurtscheller","year":"1996","journal-title":"Int. J. Psychophysiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.neuroimage.2006.06.005","article-title":"Post-movement beta rebound is generated in motor cortex: Evidence from neuromagnetic recordings","volume":"32","author":"Jurkiewicz","year":"2006","journal-title":"Neuroimage"},{"key":"ref_18","first-page":"143","article-title":"Neurofeedback: A comprehensive review on system design, methodology and clinical applications","volume":"7","author":"Marzbani","year":"2016","journal-title":"Basic Clin. Neurosci."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Anil, K., Hall, S.D., Demain, S., Freeman, J.A., Ganis, G., and Marsden, J. (2021). A Systematic Review of Neurofeedback for the Management of Motor Symptoms in Parkinson\u2019s Disease. Brain Sci., 11.","DOI":"10.3390\/brainsci11101292"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/j.clinph.2013.01.026","article-title":"Bereitschaftspotential augmentation by neuro-feedback training in Parkinson\u2019s disease","volume":"124","author":"Fumuro","year":"2013","journal-title":"Clin. Neurophysiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1080\/2326263X.2018.1440781","article-title":"Initial experience with a sensorimotor rhythm-based brain-computer interface in a Parkinson\u2019s disease patient","volume":"5","author":"Kasahara","year":"2018","journal-title":"Brain-Comput. Interfaces"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1523\/JNEUROSCI.0208-20.2020","article-title":"Neurofeedback-Linked Suppression of Cortical \u03b2 Bursts Speeds Up Movement Initiation in Healthy Motor Control: A Double-Blind Sham-Controlled Study","volume":"40","author":"He","year":"2020","journal-title":"J. Neurosci."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Cook, A.J., Pfeifer, K.J., and Tass, P.A. (2021). A Single Case Feasibility Study of Sensorimotor Rhythm Neurofeedback in Parkinson\u2019s Disease. Front. Neurosci., 15.","DOI":"10.3389\/fnins.2021.623317"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Anil, K., Demain, S., Burridge, J., Simpson, D., Taylor, J., Cotter, I., and Vuckovic, A. (2022). The importance of self-efficacy and negative affect for neurofeedback success for central neuropathic pain after a spinal cord injury. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-15213-7"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.neuroscience.2016.12.050","article-title":"Can we predict who will respond to neurofeedback? A review of the inefficacy problem and existing predictors for successful EEG neurofeedback learning","volume":"378","author":"Alkoby","year":"2018","journal-title":"Neuroscience"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.neuroimage.2018.10.021","article-title":"A systematic review of the psychological factors that influence neurofeedback learning outcomes","volume":"185","author":"Kadosh","year":"2019","journal-title":"Neuroimage"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Han, X., Shi, Z., Pei, G., Fang, B., and Yan, T. (2023, January 3\u20135). Effect of Neurofeedback Based on Imaginary Movement in Parkinson\u2019s Disease. Proceedings of the 2023 17th International Conference on Complex Medical Engineering (CME), Suzhou, China.","DOI":"10.1109\/CME60059.2023.10565497"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/0013-4694(87)90206-9","article-title":"Cerebral location of international 10\u201320 system electrode placement","volume":"66","author":"Homan","year":"1987","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3934","DOI":"10.1002\/hbm.25530","article-title":"Proactive inhibition is not modified by deep brain stimulation for Parkinson\u2019s disease: An electrical neuroimaging study","volume":"42","author":"Mouthon","year":"2021","journal-title":"Hum. Brain Mapp."},{"key":"ref_30","first-page":"243","article-title":"Impaired inhibitory control during walking in Parkinson\u2019s disease patients: An EEG study","volume":"12","author":"Sosnik","year":"2022","journal-title":"J. Park. Dis."},{"key":"ref_31","unstructured":"Hancock, P.A., and Meshkati, N. (1988). Development of NASA-TLX (Task Load Index): Results of Empirical and Theoretical Research. Advances in Psychology, North-Holland."},{"key":"ref_32","unstructured":"Medine, D. (2021, January 01). LSL-actiCHamp. Available online: https:\/\/github.com\/brain-products\/LSL-actiCHamp."},{"key":"ref_33","unstructured":"Boulay, C. (2021, January 01). App-LabRecorder. Available online: https:\/\/github.com\/labstreaminglayer\/App-LabRecorder."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1163\/156856897X00357","article-title":"The Psychophysics Toolbox","volume":"10","author":"Brainard","year":"1997","journal-title":"Spat. Vis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jneumeth.2003.10.009","article-title":"EEGLAB: An open source toolbox for analysis of single-trial EEG dynamics including independent component analysis","volume":"134","author":"Delorme","year":"2004","journal-title":"J. Neurosci. Methods"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1365-2648.2007.04569.x","article-title":"The qualitative content analysis process","volume":"62","author":"Elo","year":"2008","journal-title":"J. Adv. Nurs."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1162\/jocn_a_01250","article-title":"Transient alpha and beta synchrony underlies preparatory recruitment of directional motor networks","volume":"30","author":"Rhodes","year":"2018","journal-title":"J. Cogn. Neurosci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1523\/JNEUROSCI.1887-19.2019","article-title":"\u03b2-bursts reveal the trial-to-trial dynamics of movement initiation and cancellation","volume":"40","author":"Wessel","year":"2020","journal-title":"J. Neurosci."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Cooke, A., Hindle, J., Lawrence, C., Bellomo, E., Pritchard, A.W., MacLeod, C.A., Martin-Forbes, P., Jones, S., Bracewell, M., and Linden, D.E. (2024). Effects of Home-Based EEG Neurofeedback Training as a Non-Pharmacological Intervention for Parkinson\u2019s Disease. medRxiv, 2.","DOI":"10.1016\/j.neucli.2024.102997"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1109\/TNSRE.2016.2597243","article-title":"Neurofeedback control in Parkinsonian patients using electrocorticography signals accessed wirelessly with a chronic, fully implanted device","volume":"25","author":"Khanna","year":"2016","journal-title":"IEEE Trans. Neural Syst. Rehabil. Eng."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1523\/ENEURO.0246-18.2018","article-title":"Real-time neurofeedback to modulate \u03b2-band power in the subthalamic nucleus in Parkinson\u2019s disease patients","volume":"5","author":"Fukuma","year":"2018","journal-title":"Eneuro"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e60979","DOI":"10.7554\/eLife.60979","article-title":"Subthalamic beta-targeted neurofeedback speeds up movement initiation but increases tremor in Parkinsonian patients","volume":"9","author":"He","year":"2020","journal-title":"Elife"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Kober, S.E., Witte, M., Ninaus, M., Neuper, C., and Wood, G. (2013). Learning to modulate one\u2019s own brain activity: The effect of spontaneous mental strategies. Front. Hum. Neurosci., 7.","DOI":"10.3389\/fnhum.2013.00695"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ijpsycho.2012.07.182","article-title":"Individual alpha neurofeedback training effect on short term memory","volume":"86","author":"Nan","year":"2012","journal-title":"Int. J. Psychophysiol."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/24\/16\/5107\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T12:53:49Z","timestamp":1723035229000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/24\/16\/5107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,6]]},"references-count":44,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["s24165107"],"URL":"https:\/\/doi.org\/10.3390\/s24165107","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,6]]}}}