{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:50:32Z","timestamp":1740149432201,"version":"3.37.3"},"reference-count":49,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"Accurate assessment of Parkinson\u2019s disease (PD) ON and OFF states in the usual environment is essential for tailoring optimal treatments. Wearables facilitate measurements of gait in novel and unsupervised environments; however, differences between unsupervised and in-laboratory measures have been reported in PD. We aimed to investigate whether unsupervised gait speed discriminates medication states and which supervised tests most accurately represent home performance. In-lab gait speeds from different gait tasks were compared to home speeds of 27 PD patients at ON and OFF states using inertial sensors. Daily gait speed distribution was expressed in percentiles and walking bout (WB) length. Gait speeds differentiated ON and OFF states in the lab and the home. When comparing lab with home performance, ON assessments in the lab showed moderate-to-high correlations with faster gait speeds in unsupervised environment (r = 0.69; p < 0.001), associated with long WB. OFF gait assessments in the lab showed moderate correlation values with slow gait speeds during OFF state at home (r = 0.56; p = 0.004), associated with short WB. In-lab and daily assessments of gait speed with wearables capture additional integrative aspects of PD, reflecting different aspects of mobility. Unsupervised assessment using wearables adds complementary information to the clinical assessment of motor fluctuations in PD.<\/jats:p>","DOI":"10.3390\/s21123974","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T08:22:22Z","timestamp":1623226942000},"page":"3974","source":"Crossref","is-referenced-by-count":16,"title":["Comparison of Laboratory and Daily-Life Gait Speed Assessment during ON and OFF States in Parkinson\u2019s Disease"],"prefix":"10.3390","volume":"21","author":[{"given":"Marta Francisca","family":"Corr\u00e0","sequence":"first","affiliation":[{"name":"Abel Salazar Biomedical Sciences Institute (ICBAS), University of Porto, 4050-313 Porto, Portugal"},{"name":"University Hospital Santo Antonio of Porto (CHUP), 4099-001 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7751-2691","authenticated-orcid":false,"given":"Arash","family":"Atrsaei","sequence":"additional","affiliation":[{"name":"Laboratory of Movement Analysis and Measurement, Swiss Federal Institute of Technology in Lausanne (EPFL), 1015 Lausanne, Switzerland"}]},{"given":"Ana","family":"Sardoreira","sequence":"additional","affiliation":[{"name":"University Hospital Santo Antonio of Porto (CHUP), 4099-001 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4813-3868","authenticated-orcid":false,"given":"Clint","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Christian-Albrechts-University, 24118 Kiel, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6582-5375","authenticated-orcid":false,"given":"Kamiar","family":"Aminian","sequence":"additional","affiliation":[{"name":"Laboratory of Movement Analysis and Measurement, Swiss Federal Institute of Technology in Lausanne (EPFL), 1015 Lausanne, Switzerland"}]},{"given":"Manuel","family":"Correia","sequence":"additional","affiliation":[{"name":"Abel Salazar Biomedical Sciences Institute (ICBAS), University of Porto, 4050-313 Porto, Portugal"},{"name":"University Hospital Santo Antonio of Porto (CHUP), 4099-001 Porto, Portugal"}]},{"given":"Nuno","family":"Vila-Ch\u00e3","sequence":"additional","affiliation":[{"name":"University Hospital Santo Antonio of Porto (CHUP), 4099-001 Porto, Portugal"}]},{"given":"Walter","family":"Maetzler","sequence":"additional","affiliation":[{"name":"Department of Neurology, Christian-Albrechts-University, 24118 Kiel, Germany"}]},{"given":"Lu\u00eds","family":"Maia","sequence":"additional","affiliation":[{"name":"Abel Salazar Biomedical Sciences Institute (ICBAS), University of Porto, 4050-313 Porto, Portugal"},{"name":"University Hospital Santo Antonio of Porto (CHUP), 4099-001 Porto, Portugal"},{"name":"Institute for Research and Innovation in Health (i3s), University of Porto, 4200-135 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nrn983","article-title":"Pathogenesis of parkinson\u2019s disease: Dopamine, vesicles and \u03b1-synuclein","volume":"3","author":"Lotharius","year":"2002","journal-title":"Nat. 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