{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,12,29]],"date-time":"2024-12-29T19:40:09Z","timestamp":1735501209726,"version":"3.32.0"},"reference-count":53,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T00:00:00Z","timestamp":1578441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Institute of Information & Communications Technology Planning & Evaluation","award":["2017-0-00432"]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2019R1A2C2086593"],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"Asynchronous brain\u2013computer interfaces (BCIs) based on electroencephalography (EEG) generally suffer from poor performance in terms of classification accuracy and false-positive rate (FPR). Thus, BCI toggle switches based on electrooculogram (EOG) signals were developed to toggle on\/off synchronous BCI systems. The conventional BCI toggle switches exhibit fast responses with high accuracy; however, they have a high FPR or cannot be applied to patients with oculomotor impairments. To circumvent these issues, we developed a novel BCI toggle switch that users can employ to toggle on or off synchronous BCIs by holding their breath for a few seconds. Two states\u2014normal breath and breath holding\u2014were classified using a linear discriminant analysis with features extracted from the respiration-modulated photoplethysmography (PPG) signals. A real-time BCI toggle switch was implemented with calibration data trained with only 1-min PPG data. We evaluated the performance of our PPG switch by combining it with a steady-state visual evoked potential-based BCI system that was designed to control four external devices, with regard to the true-positive rate and FPR. The parameters of the PPG switch were optimized through an offline experiment with five subjects, and the performance of the switch system was evaluated in an online experiment with seven subjects. All the participants successfully turned on the BCI by holding their breath for approximately 10 s (100% accuracy), and the switch system exhibited a very low FPR of 0.02 false operations per minute, which is the lowest FPR reported thus far. All participants could successfully control external devices in the synchronous BCI mode. Our results demonstrated that the proposed PPG-based BCI toggle switch can be used to implement practical BCIs.<\/jats:p>","DOI":"10.3390\/s20020348","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T08:07:11Z","timestamp":1578557231000},"page":"348","source":"Crossref","is-referenced-by-count":9,"title":["Development of a Brain\u2013Computer Interface Toggle Switch with Low False-Positive Rate Using Respiration-Modulated Photoplethysmography"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8668-3989","authenticated-orcid":false,"given":"Chang-Hee","family":"Han","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Hanyang University, Seoul 04763, Korea"}]},{"given":"Euijin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Hanyang University, Seoul 04763, Korea"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3795-3318","authenticated-orcid":false,"given":"Chang-Hwan","family":"Im","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Hanyang University, Seoul 04763, Korea"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S1388-2457(02)00057-3","article-title":"Brain\u2013computer interfaces for communication and control","volume":"113","author":"Wolpaw","year":"2002","journal-title":"Clin. 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