{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T12:11:00Z","timestamp":1743768660681,"version":"3.37.3"},"reference-count":37,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T00:00:00Z","timestamp":1573516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/110438\/2015; UID\/CEC\/00127\/2019; UID\/CEC\/00127\/2013; Incentivo\/EEI\/UI0127\/2014; FCOMP-01-0124-FEDER-028943 and FCOMP-01-0124-FEDER-029673"],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Centro Hospitalar do Porto","award":["BI.02\/2018\/UCA\/CHP","NORTE-01-0145-FEDER-000016; NORTE-01-0145-FEDER-000020"]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"Motion analysis systems based on a single markerless RGB-D camera are more suitable for clinical practice than multi-camera marker-based reference systems. Nevertheless, the validity of RGB-D cameras for motor function assessment in some diseases affecting gait, such as Transthyretin Familial Amyloid Polyneuropathy (TTR-FAP), is yet to be investigated. In this study, the agreement between the Kinect v2 and a reference system for obtaining spatiotemporal and kinematic gait parameters was evaluated in the context of TTR-FAP. 3-D body joint data provided by both systems were acquired from ten TTR-FAP symptomatic patients, while performing ten gait trials. For each gait cycle, we computed several spatiotemporal and kinematic gait parameters. We then determined, for each parameter, the Bland Altman\u2019s bias and 95% limits of agreement, as well as the Pearson\u2019s and concordance correlation coefficients, between systems. The obtained results show that an affordable, portable and non-invasive system based on an RGB-D camera can accurately obtain most of the studied gait parameters (excellent or good agreement for eleven spatiotemporal and one kinematic). This system can bring more objectivity to motor function assessment of polyneuropathy patients, potentially contributing to an improvement of TTR-FAP treatment and understanding, with great benefits to the patients\u2019 quality of life.<\/jats:p>","DOI":"10.3390\/s19224929","type":"journal-article","created":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T14:11:27Z","timestamp":1573654287000},"page":"4929","source":"Crossref","is-referenced-by-count":28,"title":["Validation of a Single RGB-D Camera for Gait Assessment of Polyneuropathy Patients"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5012-789X","authenticated-orcid":false,"given":"Maria do Carmo","family":"Vilas-Boas","sequence":"first","affiliation":[{"name":"Institute for Systems Engineering and Computers \u2013 Technology and Science (INESC TEC), and Faculty of Engineering (FEUP), University of Porto, 4200-391 Porto, Portugal"},{"name":"Unidade Corino de Andrade, Hospital Santo Ant\u00f3nio, Centro Hospitalar Universit\u00e1rio do Porto, E. P. E., 4099-001 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4094-7982","authenticated-orcid":false,"given":"Ana Patr\u00edcia","family":"Rocha","sequence":"additional","affiliation":[{"name":"Institute of Electronics and Informatics Engineering of Aveiro (IEETA), and Department of Electronics, Telecommunications and Informatics, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0864-3003","authenticated-orcid":false,"given":"Hugo Miguel Pereira","family":"Choupina","sequence":"additional","affiliation":[{"name":"Institute for Systems Engineering and Computers \u2013 Technology and Science (INESC TEC), and Faculty of Engineering (FEUP), University of Porto, 4200-391 Porto, Portugal"}]},{"given":"M\u00e1rcio Neves","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Unidade Corino de Andrade, Hospital Santo Ant\u00f3nio, Centro Hospitalar Universit\u00e1rio do Porto, E. P. E., 4099-001 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0681-9354","authenticated-orcid":false,"given":"Jos\u00e9 Maria","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Institute of Electronics and Informatics Engineering of Aveiro (IEETA), and Department of Electronics, Telecommunications and Informatics, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"given":"Teresa","family":"Coelho","sequence":"additional","affiliation":[{"name":"Unidade Corino de Andrade, Hospital Santo Ant\u00f3nio, Centro Hospitalar Universit\u00e1rio do Porto, E. P. E., 4099-001 Porto, Portugal"}]},{"given":"Jo\u00e3o Paulo Silva","family":"Cunha","sequence":"additional","affiliation":[{"name":"Institute for Systems Engineering and Computers \u2013 Technology and Science (INESC TEC), and Faculty of Engineering (FEUP), University of Porto, 4200-391 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2019,11,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1007\/s00415-017-8708-4","article-title":"Transthyretin familial amyloid polyneuropathy: An update","volume":"265","year":"2018","journal-title":"J. Neurol."},{"key":"ref_2","unstructured":"Coutinho, P., Silva, A.L.d., Lopes, J., Resende, P.-E., Silva, A.M.d., Resende, L.A.L., Silva, A.M.d., Lima, J.L., and Barbosa, A.R. (1980). 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