{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T15:19:48Z","timestamp":1722179988249},"reference-count":61,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2010,8,9]],"date-time":"2010-08-09T00:00:00Z","timestamp":1281312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"Glucose control is the cornerstone of Diabetes Mellitus (DM) treatment. Although self-regulation using capillary glycemia (SRCG) still remains the best procedure in clinical practice, continuous glucose monitoring systems (CGM) offer the possibility of continuous and dynamic assessment of interstitial glucose concentration. CGM systems have the potential to improve glycemic control while decreasing the incidence of hypoglycemia but the efficiency, compared with SRCG, is still debated. CGM systems have the greatest potential value in patients with hypoglycemic unawareness and in controlling daily fluctuations in blood glucose. The implementation of continuous monitoring in the standard clinical setting has not yet been established but a new generation of open and close loop subcutaneous insulin infusion devices are emerging making insulin treatment and glycemic control more reliable.Glucose control is the cornerstone of Diabetes Mellitus (DM) treatment. Although self-regulation using capillary glycemia (SRCG) still remains the best procedure in clinical practice, continuous glucose monitoring systems (CGM) offer the possibility of continuous and dynamic assessment of interstitial glucose concentration. CGM systems have the potential to improve glycemic control while decreasing the incidence of hypoglycemia but the efficiency, compared with SRCG, is still debated. CGM systems have the greatest potential value in patients with hypoglycemic unawareness and in controlling daily fluctuations in blood glucose. The implementation of continuous monitoring in the standard clinical setting has not yet been established but a new generation of open and close loop subcutaneous insulin infusion devices are emerging making insulin treatment and glycemic control more reliable.<\/jats:p>","DOI":"10.3390\/s100807404","type":"journal-article","created":{"date-parts":[[2010,8,9]],"date-time":"2010-08-09T15:13:47Z","timestamp":1281366827000},"page":"7404-7420","source":"Crossref","is-referenced-by-count":12,"title":["Use of Sensors in the Treatment and Follow-up of Patients with Diabetes Mellitus"],"prefix":"10.3390","volume":"10","author":[{"given":"Isabel","family":"Torres","sequence":"first","affiliation":[{"name":"Endocrinology and Nutrition Service, Hospital Puerta del Mar, Ana de Viya 21, 11009 Cadiz, Spain"}]},{"given":"Maria G.","family":"Baena","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Service, Hospital Puerta del Mar, Ana de Viya 21, 11009 Cadiz, Spain"}]},{"given":"Manuel","family":"Cayon","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Service, Hospital Puerta del Mar, Ana de Viya 21, 11009 Cadiz, Spain"}]},{"given":"Jose","family":"Ortego-Rojo","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Service, Hospital Puerta del Mar, Ana de Viya 21, 11009 Cadiz, Spain"}]},{"given":"Manuel","family":"Aguilar-Diosdado","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Service, Hospital Puerta del Mar, Ana de Viya 21, 11009 Cadiz, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2010,8,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.2337\/diacare.26.2007.S5","article-title":"Report of the expert committee on the diagnosis and classification of diabetes mellitus","volume":"26","author":"Gavin","year":"2003","journal-title":"Diabetes Care"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2337\/diacare.27.5.1047","article-title":"Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030","volume":"27","author":"Wild","year":"2004","journal-title":"Diabetes Care"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1212\/WNL.43.4.817","article-title":"The prevalence by staged severity of various types of diabetic neuropathy, retinopathy, and nephropathy in a population-based cohort: The Rochester diabetic neuropathy study","volume":"43","author":"Dyck","year":"1993","journal-title":"Neurology"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"(1993). The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N. Engl. J. Med, 329, 977\u2013986.","DOI":"10.1056\/NEJM199309303291401"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1056\/NEJMoa052187","article-title":"Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes","volume":"353","author":"Nathan","year":"2005","journal-title":"N. Engl. J. Med"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"(1998). UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet, 352, 837\u2013853.","DOI":"10.1016\/S0140-6736(98)07019-6"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0168-8227(95)01064-K","article-title":"Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: A randomized prospective 6-year study","volume":"28","author":"Ohkubo","year":"1995","journal-title":"Diabetes Res. Clin. Pract"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1056\/NEJMoa0806470","article-title":"10-year follow-up of intensive glucose control in type 2 diabetes","volume":"359","author":"Holman","year":"2008","journal-title":"N. Engl. J. Med"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1056\/NEJMoa0802743","article-title":"Effects of intensive glucose lowering in type 2 diabetes","volume":"358","author":"Gerstein","year":"2008","journal-title":"N. Engl. J. Med"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1056\/NEJMoa0802987","article-title":"Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes","volume":"358","author":"Patel","year":"2008","journal-title":"N. Engl. J. Med"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1056\/NEJMoa0808431","article-title":"Glucose control and vascular complications in veterans with type 2 diabetes","volume":"360","author":"Duckworth","year":"2009","journal-title":"N. Engl. J. Med"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1007\/s00125-009-1470-0","article-title":"Intensive glucose control and macrovascular outcomes in type 2 diabetes","volume":"52","author":"Turnbull","year":"2009","journal-title":"Diabetologia"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1016\/j.clinthera.2009.10.006","article-title":"Comparison of insulin detemir and insulin glargine in a basal-bolus regimen, with insulin aspart as the mealtime insulin, in patients with type 1 diabetes: A 52-week, multinational, randomized, open-label, parallel-group, treat-to-target non-inferiority trial","volume":"31","author":"Heller","year":"2009","journal-title":"Clin. Ther"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1007\/s00125-009-1468-7","article-title":"Optimal insulin regimens in type 2 diabetes mellitus: Systematic review and meta-analyses","volume":"52","author":"Lasserson","year":"2009","journal-title":"Diabetologia"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1001\/jama.298.2.194","article-title":"Efficacy and safety of incretin therapy in type 2 diabetes: Systematic review and meta-analysis","volume":"298","author":"Amori","year":"2007","journal-title":"JAMA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.2337\/dc06-2593","article-title":"Liraglutide, a long-acting human glucagon-like peptide-1 analog, given as monotherapy significantly improves glycemic control and lowers body weight without risk of hypoglycemia in patients with type 2 diabetes","volume":"30","author":"Vilsboll","year":"2007","journal-title":"Diabetes Care"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.2337\/dc06-0703","article-title":"Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes","volume":"29","author":"Aschner","year":"2006","journal-title":"Diabetes Care"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S1262-3636(08)73972-7","article-title":"Treatment of diabetes mellitus using an external insulin pump: The state of the art","volume":"344","author":"Hanaire","year":"2008","journal-title":"Diabetes Metab"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1210\/jc.2008-2625","article-title":"Clinical review: Realistic expectations and practical use of continuous glucose monitoring for the endocrinologist","volume":"94","author":"Hirsch","year":"2009","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2337\/diacare.27.7.1761","article-title":"Tests of glycemia in diabetes","volume":"27","author":"Goldstein","year":"2004","journal-title":"Diabetes Care"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1185\/03007990903094452","article-title":"An overview and commentary on retrospective, continuous glucose monitoring for the optimisation of care for people with diabetes","volume":"25","author":"Currie","year":"2009","journal-title":"Curr. Med. Res. Opin"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.2337\/diacare.28.5.1231","article-title":"Continuous glucose monitoring: Roadmap for 21st century diabetes therapy","volume":"28","author":"Klonoff","year":"2005","journal-title":"Diabetes Care"},{"key":"ref_23","first-page":"429","article-title":"Continuous subcutaneous glucose monitoring: The GlucoDay system","volume":"15","author":"Maran","year":"2002","journal-title":"Diabetes Nutr. Metab"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2337\/diacare.25.2.347","article-title":"Continuous subcutaneous glucose monitoring in diabetic patients: A multicenter analysis","volume":"25","author":"Maran","year":"2002","journal-title":"Diabetes Care"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"(2009). American Diabetes Association. Standards of medical care in diabetes\u20142009. Diabetes Care, 32, 13\u201361.","DOI":"10.2337\/dc09-S013"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1089\/dia.2009.0045","article-title":"Continuous glucose monitoring: An overview of its development","volume":"11","author":"Skyler","year":"2009","journal-title":"Diabetes Technol. Ther"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1464-5491.2008.02642.x","article-title":"Glucose sensors: A review of current and emerging technology","volume":"26","author":"Oliver","year":"2009","journal-title":"Diabet. Med"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.2337\/dc07-2401","article-title":"Comparison of the numerical and clinical accuracy of four continuous glucose monitors","volume":"31","author":"Kovatchev","year":"2008","journal-title":"Diabetes Care"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1089\/dia.2007.0261","article-title":"Continuous glucose monitoring and diabetes health outcomes: A critical appraisal","volume":"10","author":"Reach","year":"2008","journal-title":"Diabetes Technol. Ther"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.2337\/diacare.28.10.2412","article-title":"Evaluating the clinical accuracy of two continuous glucose sensors using continuous glucose-error grid analysis","volume":"28","author":"Clarke","year":"2005","journal-title":"Diabetes Care"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.2337\/dc06-1602","article-title":"Accuracy of the 5-day FreeStyle Navigator Continuous Glucose Monitoring System: Comparison with frequent laboratory reference measurements","volume":"30","author":"Weinstein","year":"2007","journal-title":"Diabetes Care"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1177\/193229680900300519","article-title":"Accuracy of the SEVEN continuous glucose monitoring system: Comparison with frequently sampled venous glucose measurements","volume":"3","author":"Zisser","year":"2009","journal-title":"J. Diabetes Sci. Technol"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/dmrr.209","article-title":"Making \u201csense\u201d of diabetes: Using a continuous glucose sensor in clinical practice","volume":"18","author":"Cheyne","year":"2002","journal-title":"Diabetes Metab. Res. Rev"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1089\/152091500316737","article-title":"Performance evaluation of the MiniMed continuous glucose monitoring system during patient home use","volume":"2","author":"Gross","year":"2000","journal-title":"Diabetes Technol. Ther"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0956-5663(02)00215-4","article-title":"A microdialysis technique for continuous subcutaneous glucose monitoring in diabetic patients (part 2)","volume":"18","author":"Varalli","year":"2003","journal-title":"Biosens. Bioelectron"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0956-5663(02)00216-6","article-title":"A microdialysis technique for continuous subcutaneous glucose monitoring in diabetic patients (part 1)","volume":"18","author":"Poscia","year":"2003","journal-title":"Biosens. Bioelectron"},{"key":"ref_37","first-page":"81","article-title":"Continuous monitoring of blood glucose","volume":"57","author":"Robert","year":"2002","journal-title":"Horm. Res"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1089\/dia.2008.0133","article-title":"The chemistry of commercial continuous glucose monitors","volume":"11","author":"McGarraugh","year":"2009","journal-title":"Diabetes Technol. Ther"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1089\/dia.2008.0016","article-title":"Clinical application of emerging sensor technologies in diabetes management: Consensus guidelines for continuous glucose monitoring (CGM)","volume":"10","author":"Hirsch","year":"2008","journal-title":"Diabetes Technol. Ther"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1089\/dia.2009.0012","article-title":"Continuous glucose monitoring health outcomes","volume":"11","author":"Edelman","year":"2009","journal-title":"Diabetes Technol. Ther"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1001\/jama.295.14.1707","article-title":"Glycemic variability: A hemoglobin A1c-independent risk factor for diabetic complications","volume":"295","author":"Brownlee","year":"2006","journal-title":"JAMA"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"371","DOI":"10.4158\/EP09287.OR","article-title":"Benefits of Continuous Glucose Monitor Use in Clinical Practice","volume":"16","author":"Leinung","year":"2010","journal-title":"Endocr. Pract"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1136\/bmj.a1680","article-title":"Effectiveness of continuous glucose monitoring in pregnant women with diabetes: Randomised clinical trial","volume":"337","author":"Murphy","year":"2008","journal-title":"BMJ"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.2337\/dc06-1134","article-title":"Improved glycemic control in poorly controlled patients with type 1 diabetes using real-time continuous glucose monitoring","volume":"29","author":"Deiss","year":"2006","journal-title":"Diabetes Care"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"44","DOI":"10.2337\/diacare.29.01.06.dc05-1686","article-title":"Improvement in glycemic excursions with a transcutaneous, real-time continuous glucose sensor: A randomized controlled trial","volume":"29","author":"Garg","year":"2006","journal-title":"Diabetes Care"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1055\/s-0029-1225337","article-title":"Benefits of continuous subcutaneous insulin infusion in type 1 diabetes previously treated with multiple daily injections with once-daily glargine and pre-meal analogues","volume":"117","author":"Torres","year":"2009","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.2337\/diacare.26.4.1079","article-title":"Insulin pump therapy: A meta-analysis","volume":"26","author":"Seshadri","year":"2003","journal-title":"Diabetes Care"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/dmrr.614","article-title":"Determinants of glycaemic control in type 1 diabetes during intensified therapy with multiple daily insulin injections or continuous subcutaneous insulin infusion: Importance of blood glucose variability","volume":"22","author":"Pickup","year":"2006","journal-title":"Diabetes Metab. Res. Rev"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1464-5491.2008.02486.x","article-title":"Severe hypoglycaemia and glycaemic control in Type 1 diabetes: Meta-analysis of multiple daily insulin injections compared with continuous subcutaneous insulin infusion","volume":"25","author":"Pickup","year":"2008","journal-title":"Diabet. Med"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1001\/archinte.161.19.2293","article-title":"Continuous subcutaneous insulin infusion: A comprehensive review of insulin pump therapy","volume":"161","author":"Lenhard","year":"2001","journal-title":"Arch. Intern. Med"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3810\/pgm.2002.05.1200","article-title":"Insulin pump therapy in the 21st century. Strategies for successful use in adults, adolescents, and children with diabetes","volume":"111","author":"Bode","year":"2002","journal-title":"Postgrad. Med"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"593","DOI":"10.2337\/diacare.25.3.593","article-title":"Continuous subcutaneous insulin infusion at 25 years: Evidence base for the expanding use of insulin pump therapy in type 1 diabetes","volume":"25","author":"Pickup","year":"2002","journal-title":"Diabetes Care"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.2337\/dc09-0750","article-title":"Incremental value of continuous glucose monitoring when starting pump therapy in patients with poorly controlled type 1 diabetes: The Real Trend study","volume":"32","author":"Raccah","year":"2009","journal-title":"Diabetes Care"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1089\/dia.2008.0068","article-title":"Sensor-augmented insulin pump therapy: Results of the first randomized treat-to-target study","volume":"10","author":"Hirsch","year":"2008","journal-title":"Diabetes Technol. Ther"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1007\/s00125-009-1365-0","article-title":"Glycaemic impact of patient-led use of sensor-guided pump therapy in type 1 diabetes: A randomised controlled trial","volume":"52","author":"Donath","year":"2009","journal-title":"Diabetologia"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.2337\/dc09-0889","article-title":"Factors predictive of use and of benefit from continuous glucose monitoring in type 1 diabetes","volume":"32","author":"Beck","year":"2009","journal-title":"Diabetes Care"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1056\/NEJMoa0805017","article-title":"Continuous glucose monitoring and intensive treatment of type 1 diabetes","volume":"359","author":"Tamborlane","year":"2008","journal-title":"N. Engl. J. 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