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The current study was set up to look at associations between isolated and comorbid diseases of bronchial asthma and hypertension, on one hand, and single nucleotide polymorphisms associated with regulation of gene expression (eQTL), on the other hand. A total of 96 eQTL SNPs were genotyped in 587 Russian individuals. Bronchial asthma alone was found to be associated with rs1927914 (TLR4<\/jats:italic>), rs1928298 (intergenic variant), and rs1980616 (SERPINA1<\/jats:italic>); hypertension alone was found to be associated with rs11065987 (intergenic variant); rs2284033 (IL2RB<\/jats:italic>), rs11191582 (NT5C2<\/jats:italic>), and rs11669386 (CARD8<\/jats:italic>); comorbidity between asthma and hypertension was found to be associated with rs1010461 (ANG\/RNASE4<\/jats:italic>), rs7038716, rs7026297 (LOC105376244<\/jats:italic>), rs7025144 (intergenic variant), and rs2022318 (intergenic variant). The results suggest that genetic background of comorbidity of asthma and hypertension is different from genetic backgrounds of both diseases manifesting isolated.<\/jats:p>","DOI":"10.1515\/jib-2018-0052","type":"journal-article","created":{"date-parts":[[2018,12,9]],"date-time":"2018-12-09T09:02:41Z","timestamp":1544346161000},"source":"Crossref","is-referenced-by-count":13,"title":["Molecular Relationships between Bronchial Asthma and Hypertension as Comorbid Diseases"],"prefix":"10.1515","volume":"15","author":[{"ORCID":"http:\/\/orcid.org\/0000-0002-1103-3073","authenticated-orcid":false,"given":"Elena Yu.","family":"Bragina","sequence":"first","affiliation":[{"name":"Research Institute of Medical Genetics, Tomsk NRMC , Tomsk , Russia"}]},{"ORCID":"http:\/\/orcid.org\/0000-0002-9527-7015","authenticated-orcid":false,"given":"Irina A.","family":"Goncharova","sequence":"additional","affiliation":[{"name":"Research Institute of Medical Genetics, Tomsk NRMC , Tomsk , Russia"}]},{"given":"Anna F.","family":"Garaeva","sequence":"additional","affiliation":[{"name":"Research Institute of Medical Genetics, Tomsk NRMC , Tomsk , Russia"},{"name":"Siberian State Medical University , Tomsk , Russia"}]},{"given":"Evgeniy V.","family":"Nemerov","sequence":"additional","affiliation":[{"name":"Siberian State Medical University , Tomsk , Russia"}]},{"given":"Anastasija A.","family":"Babovskaya","sequence":"additional","affiliation":[{"name":"Siberian State Medical University , Tomsk , Russia"}]},{"given":"Andrey B.","family":"Karpov","sequence":"additional","affiliation":[{"name":"Seversk Biophysical Research Centre of the Federal Medico-Biological Agency , Seversk , Russia"}]},{"given":"Yulia V.","family":"Semenova","sequence":"additional","affiliation":[{"name":"Seversk Clinical Hospital, Siberian Federal Research and Clinical Centre of the Federal Medico-Biological Agency , Seversk , Russia"}]},{"given":"Irina Z.","family":"Zhalsanova","sequence":"additional","affiliation":[{"name":"Research Institute of Medical Genetics, Tomsk NRMC , Tomsk , Russia"}]},{"given":"Densema E.","family":"Gomboeva","sequence":"additional","affiliation":[{"name":"Research Institute of Medical Genetics, Tomsk NRMC , Tomsk , Russia"}]},{"given":"Olga V.","family":"Saik","sequence":"additional","affiliation":[{"name":"The Federal Research Center Institute of Cytology and Genetics , The Siberian Branch of the Russian Academy of Sciences , Novosibirsk , Russia"}]},{"ORCID":"http:\/\/orcid.org\/0000-0002-9424-8052","authenticated-orcid":false,"given":"Olga I.","family":"Zolotareva","sequence":"additional","affiliation":[{"name":"Bielefeld University , Bioinformatics\/Medical Informatics Department , Bielefeld , Germany"},{"name":"International Research Training Group \u201cComputational Methods for the Analysis of the Diversity and Dynamics of Genomes\u201d and Genome Informatics , Faculty of Technology and Center for Biotechnology, Bielefeld University , Bielefeld , Germany"}]},{"given":"Vladimir A.","family":"Ivanisenko","sequence":"additional","affiliation":[{"name":"The Federal Research Center Institute of Cytology and Genetics , The Siberian Branch of the Russian Academy of Sciences , Novosibirsk , Russia"}]},{"given":"Victor E.","family":"Dosenko","sequence":"additional","affiliation":[{"name":"Bogomoletz Institute of Physiology, National Academy of Science , Kiev , Ukraine"}]},{"given":"Ralf","family":"Hofestaedt","sequence":"additional","affiliation":[{"name":"Bielefeld University , Bioinformatics\/Medical Informatics Department , Bielefeld , Germany"}]},{"ORCID":"http:\/\/orcid.org\/0000-0002-1439-6259","authenticated-orcid":false,"given":"Maxim B.","family":"Freidin","sequence":"additional","affiliation":[{"name":"Research Institute of Medical Genetics, Tomsk NRMC , Tomsk , Russia"}]}],"member":"374","published-online":{"date-parts":[[2018,12,10]]},"reference":[{"key":"2023033120003912177_j_jib-2018-0052_ref_001_w2aab3b7b5b1b6b1ab1b6b1Aa","doi-asserted-by":"crossref","unstructured":"Divo MJ, Martinez CH, Mannino DM. 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