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Because of technological limitations for observations at mesoscopic scales, the precise structural organisation of the ECM is not well-known, with sparse or fuzzy experimental observables. Based on the Unity3D game and physics engines, along with rigid body dynamics, we propose a virtual sandbox to model large biological molecules as dynamic chains of rigid bodies interacting together to gain insight into ECM components behaviour in the mesoscopic range. We have preliminary results showing how parameters such as fibre flexibility or the nature and number of interactions between molecules can induce different structures in the basement membrane. Using the Unity3D game engine and virtual reality headset coupled with haptic controllers, we immerse the user inside the corresponding simulation. Untrained users are able to navigate a complex virtual sandbox crowded with large biomolecules models in a matter of seconds.<\/jats:p>","DOI":"10.1515\/jib-2018-0009","type":"journal-article","created":{"date-parts":[[2018,6,10]],"date-time":"2018-06-10T22:15:58Z","timestamp":1528668958000},"source":"Crossref","is-referenced-by-count":9,"title":["Mesoscopic Rigid Body Modelling of the Extracellular Matrix Self-Assembly"],"prefix":"10.1515","volume":"15","author":[{"given":"Hua","family":"Wong","sequence":"first","affiliation":[{"name":"Plateau de Mod\u00e9lisation Mol\u00e9culaire Multi-Echelle (P3M), Maison de la Simulation de Champagne-Ardenne (MaSCA) , Universit\u00e9 de Reims Champagne-Ardenne , 51687 Reims Cedex 2 , France"}]},{"given":"Jessica","family":"Pr\u00e9voteau-Jonquet","sequence":"additional","affiliation":[{"name":"UMR URCA\/CNRS 7369, Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), Equipe Mod\u00e9lisation et Imagerie Multi-Echelles (MIME) , Universit\u00e9 de Reims Champagne-Ardenne , 51687 Reims Cedex 2 , France"}]},{"given":"St\u00e9phanie","family":"Baud","sequence":"additional","affiliation":[{"name":"Plateau de Mod\u00e9lisation Mol\u00e9culaire Multi-Echelle (P3M), Maison de la Simulation de Champagne-Ardenne (MaSCA) , Universit\u00e9 de Reims Champagne-Ardenne , 51687 Reims Cedex 2 , France"},{"name":"UMR URCA\/CNRS 7369, Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), Equipe Mod\u00e9lisation et Imagerie Multi-Echelles (MIME) , Universit\u00e9 de Reims Champagne-Ardenne , 51687 Reims Cedex 2 , France"}]},{"given":"Manuel","family":"Dauchez","sequence":"additional","affiliation":[{"name":"Plateau de Mod\u00e9lisation Mol\u00e9culaire Multi-Echelle (P3M), Maison de la Simulation de Champagne-Ardenne (MaSCA) , Universit\u00e9 de Reims Champagne-Ardenne , 51687 Reims Cedex 2 , France"},{"name":"UMR URCA\/CNRS 7369, Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), Equipe Mod\u00e9lisation et Imagerie Multi-Echelles (MIME) , Universit\u00e9 de Reims Champagne-Ardenne , 51687 Reims Cedex 2 , France"}]},{"ORCID":"http:\/\/orcid.org\/0000-0002-6003-3184","authenticated-orcid":false,"given":"Nicolas","family":"Belloy","sequence":"additional","affiliation":[{"name":"Plateau de Mod\u00e9lisation Mol\u00e9culaire Multi-Echelle (P3M), Maison de la Simulation de Champagne-Ardenne (MaSCA) , Universit\u00e9 de Reims Champagne-Ardenne , 51687 Reims Cedex 2 , France"},{"name":"UMR URCA\/CNRS 7369, Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), Equipe Mod\u00e9lisation et Imagerie Multi-Echelles (MIME) , Universit\u00e9 de Reims Champagne-Ardenne , 51687 Reims Cedex 2 , France"}]}],"member":"374","published-online":{"date-parts":[[2018,6,11]]},"reference":[{"key":"2023033120302588148_j_jib-2018-0009_ref_001_w2aab3b7b5b1b6b1ab1b7b1Aa","doi-asserted-by":"crossref","unstructured":"Chautard E, Ballut L, Thierry-Mieg N, Ricard-Blum S. 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