{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T19:01:30Z","timestamp":1735585290832,"version":"3.30.1"},"update-to":[{"updated":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T00:00:00Z","timestamp":1628121600000},"DOI":"10.1371\/journal.pcbi.1009149","type":"new_version","label":"New version"}],"reference-count":95,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T00:00:00Z","timestamp":1627257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"The COVID-19 pandemic has created an urgent need for models that can project epidemic trends, explore intervention scenarios, and estimate resource needs. Here we describe the methodology of Covasim (COVID-19 Agent-based Simulator), an open-source model developed to help address these questions. Covasim includes country-specific demographic information on age structure and population size; realistic transmission networks in different social layers, including households, schools, workplaces, long-term care facilities, and communities; age-specific disease outcomes; and intrahost viral dynamics, including viral-load-based transmissibility. Covasim also supports an extensive set of interventions, including non-pharmaceutical interventions, such as physical distancing and protective equipment; pharmaceutical interventions, including vaccination; and testing interventions, such as symptomatic and asymptomatic testing, isolation, contact tracing, and quarantine. These interventions can incorporate the effects of delays, loss-to-follow-up, micro-targeting, and other factors. Implemented in pure Python, Covasim has been designed with equal emphasis on performance, ease of use, and flexibility: realistic and highly customized scenarios can be run on a standard laptop in under a minute. In collaboration with local health agencies and policymakers, Covasim has already been applied to examine epidemic dynamics and inform policy decisions in more than a dozen countries in Africa, Asia-Pacific, Europe, and North America.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1009149","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T17:40:13Z","timestamp":1627321213000},"page":"e1009149","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":373,"title":["Covasim: An agent-based model of COVID-19 dynamics and interventions"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2517-2354","authenticated-orcid":true,"given":"Cliff C.","family":"Kerr","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5482-9584","authenticated-orcid":true,"given":"Robyn M.","family":"Stuart","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1598-1388","authenticated-orcid":true,"given":"Dina","family":"Mistry","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9618-6457","authenticated-orcid":true,"given":"Romesh G.","family":"Abeysuriya","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8902-9990","authenticated-orcid":true,"given":"Katherine","family":"Rosenfeld","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0576-7430","authenticated-orcid":true,"given":"Gregory R.","family":"Hart","sequence":"additional","affiliation":[]},{"given":"Rafael C.","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8479-1860","authenticated-orcid":true,"given":"Jamie A.","family":"Cohen","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7565-2300","authenticated-orcid":true,"given":"Prashanth","family":"Selvaraj","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1489-7168","authenticated-orcid":true,"given":"Brittany","family":"Hagedorn","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8729-9268","authenticated-orcid":true,"given":"Lauren","family":"George","sequence":"additional","affiliation":[]},{"given":"Micha\u0142","family":"Jastrz\u0119bski","sequence":"additional","affiliation":[]},{"given":"Amanda S.","family":"Izzo","sequence":"additional","affiliation":[]},{"given":"Greer","family":"Fowler","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7418-9446","authenticated-orcid":true,"given":"Anna","family":"Palmer","sequence":"additional","affiliation":[]},{"given":"Dominic","family":"Delport","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9213-0798","authenticated-orcid":true,"given":"Nick","family":"Scott","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6232-5586","authenticated-orcid":true,"given":"Sherrie L.","family":"Kelly","sequence":"additional","affiliation":[]},{"given":"Caroline S.","family":"Bennette","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0496-4689","authenticated-orcid":true,"given":"Bradley G.","family":"Wagner","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7604-9797","authenticated-orcid":true,"given":"Stewart T.","family":"Chang","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1896-6079","authenticated-orcid":true,"given":"Assaf P.","family":"Oron","sequence":"additional","affiliation":[]},{"given":"Edward A.","family":"Wenger","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7720-1121","authenticated-orcid":true,"given":"Jasmina","family":"Panovska-Griffiths","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9275-7454","authenticated-orcid":true,"given":"Michael","family":"Famulare","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0437-7916","authenticated-orcid":true,"given":"Daniel J.","family":"Klein","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2021,7,26]]},"reference":[{"issue":"2","key":"pcbi.1009149.ref001","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1177\/2043820620935355","article-title":"The dashboard pandemic","volume":"10","author":"J Everts","year":"2020","journal-title":"Dialogues in Human Geography"},{"issue":"5","key":"pcbi.1009149.ref002","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S1473-3099(20)30120-1","article-title":"An interactive web-based dashboard to track COVID-19 in real time","volume":"20","author":"E Dong","year":"2020","journal-title":"The Lancet Infectious Diseases"},{"key":"pcbi.1009149.ref003","unstructured":"Public Health Seattle King County. 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