{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,10,6]],"date-time":"2024-10-06T00:46:57Z","timestamp":1728175617991},"reference-count":84,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2015,8,11]],"date-time":"2015-08-11T00:00:00Z","timestamp":1439251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1004376","type":"journal-article","created":{"date-parts":[[2015,8,11]],"date-time":"2015-08-11T17:55:33Z","timestamp":1439315733000},"page":"e1004376","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["A Spatially Detailed Model of Isometric Contraction Based on Competitive Binding of Troponin I Explains Cooperative Interactions between Tropomyosin and Crossbridges"],"prefix":"10.1371","volume":"11","author":[{"given":"Sander","family":"Land","sequence":"first","affiliation":[]},{"given":"Steven A.","family":"Niederer","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2015,8,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1113\/jphysiol.2008.164707","article-title":"Calcium- and myosin-dependent changes in troponin structure during activation of heart muscle","volume":"587","author":"YB Sun","year":"2009","journal-title":"The Journal of Physiology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1469-7793.1998.175bu.x","article-title":"Calcium cycling and contractile activation in intact mouse cardiac muscle","volume":"507","author":"WD Gao","year":"1998","journal-title":"The Journal of Physiology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"H1734","DOI":"10.1152\/ajpheart.1999.276.5.H1734","article-title":"Comparison of putative cooperative mechanisms in cardiac muscle: length dependence and dynamic responses","volume":"276","author":"JJ Rice","year":"1999","journal-title":"American Journal of Physiology\u2014Heart and Circulatory Physiology"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Trayanova NA, Rice JJ (2011) Cardiac electromechanical models: From cell to organ. Frontiers in Physiology 2.","DOI":"10.3389\/fphys.2011.00043"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1085\/jgp.201311078","article-title":"Dynamic coupling of regulated binding sites and cycling myosin heads in striated muscle","volume":"143","author":"KS Campbell","year":"2014","journal-title":"The Journal of General Physiology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1152\/physrev.2000.80.2.853","article-title":"Regulation of contraction in striated muscle","volume":"80","author":"AM Gordon","year":"2000","journal-title":"Physiological Reviews"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"8495","DOI":"10.1016\/S0021-9258(18)81818-X","article-title":"Removal of tropomyosin overlap modifies cooperative binding of myosin s-1 to reconstituted thin filaments of rabbit striated muscle","volume":"264","author":"BS Pan","year":"1989","journal-title":"The Journal of biological chemistry"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1073\/pnas.0407225102","article-title":"Mini-thin filaments regulated by troponin\u2013tropomyosin","volume":"102","author":"H Gong","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1161\/CIRCRESAHA.112.268672","article-title":"Integration of troponin I phosphorylation with cardiac regulatory networks","volume":"112","author":"RJ Solaro","year":"2013","journal-title":"Circulation Research"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1113\/jphysiol.2007.128975","article-title":"Investigation of thin filament near-neighbour regulatory unit interactions during force development in skinned cardiac and skeletal muscle","volume":"580","author":"TE Gillis","year":"2007","journal-title":"The Journal of Physiology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/cm.20321","article-title":"Phosphorylation of tropomyosin extends cooperative binding of myosin beyond a single regulatory unit","volume":"66","author":"VS Rao","year":"2009","journal-title":"Cell Motility and the Cytoskeleton"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"7209","DOI":"10.1073\/pnas.77.12.7209","article-title":"Kinetic studies of the cooperative binding of subfragment 1 to regulated actin","volume":"77","author":"KM Trybus","year":"1980","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1016\/S0006-3495(01)75875-4","article-title":"Nonlinear myofilament regulatory processes affect frequency-dependent muscle fiber stiffness","volume":"81","author":"KB Campbell","year":"2001","journal-title":"Biophysical Journal"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Tanner B, Daniel T, Regnier M (2012) Filament compliance influences cooperative activation of thin filaments and the dynamics of force production in skeletal muscle. PLoS Computational Biology 8.","DOI":"10.1371\/journal.pcbi.1002506"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"3692","DOI":"10.1016\/j.bpj.2009.02.018","article-title":"Cooperative cross-bridge activation of thin filaments contributes to the frank-starling mechanism in cardiac muscle","volume":"96","author":"L Smith","year":"2009","journal-title":"Biophysical Journal"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"C1148","DOI":"10.1152\/ajpcell.00551.2006","article-title":"Blebbistatin specifically inhibits actin-myosin interaction in mouse cardiac muscle","volume":"293","author":"Y Dou","year":"2007","journal-title":"American Journal of Physiology Cell Physiology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1016\/j.bpj.2010.09.003","article-title":"The role of thin filament cooperativity in cardiac length-dependent calcium activation","volume":"99","author":"G Farman","year":"2010","journal-title":"Biophysical Journal"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"13196","DOI":"10.1074\/jbc.272.20.13196","article-title":"Cooperative effect of calcium binding to adjacent troponin molecules on the thin filament-myosin subfragment 1 MgATPase rate","volume":"272","author":"CA Butters","year":"1997","journal-title":"Journal of Biological Chemistry"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1529\/biophysj.106.095406","article-title":"Effects of thin and thick filament proteins on calcium binding and exchange with cardiac troponin c","volume":"92","author":"JP Davis","year":"2007","journal-title":"Biophysical Journal"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1161\/01.RES.71.4.984","article-title":"Effects of cycling and rigor crossbridges on the conformation of cardiac troponin c","volume":"71","author":"JD Hannon","year":"1992","journal-title":"Circulation Research"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1469-7793.1998.431bw.x","article-title":"Changes in force and cytosolic Ca2+ concentration after length changes in isolated rat ventricular trabeculae","volume":"506","author":"JC Kentish","year":"1998","journal-title":"The Journal of Physiology"},{"key":"ref22","doi-asserted-by":"crossref","DOI":"10.1007\/978-94-010-0658-3","article-title":"Excitation-Contraction Coupling and Cardiac Contractile Force","author":"D Bers","year":"2001"},{"key":"ref23","first-page":"99","article-title":"Regulatory Mechanisms of Striated Muscle Contraction, Springer Japan, number 592 in Advances in Experimental Medicine and Biology","author":"SE Boussouf","year":"2007"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.jmb.2008.04.062","article-title":"Structural basis for the regulation of muscle contraction by troponin and tropomyosin","volume":"379","author":"A Gali\u0144ska-Rakoczy","year":"2008","journal-title":"Journal of Molecular Biology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"5038","DOI":"10.1073\/pnas.0408882102","article-title":"Ca2+-regulated structural changes in troponin","volume":"102","author":"MV Vinogradova","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.jmb.2005.12.050","article-title":"An atomic model of the thin filament in the relaxed and ca2+-activated states","volume":"357","author":"A Pirani","year":"2006","journal-title":"Journal of Molecular Biology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.abb.2013.07.013","article-title":"Structural basis for the in situ Ca(2+) sensitization of cardiac troponin c by positive feedback from force-generating myosin cross-bridges","volume":"537","author":"DC Rieck","year":"2013","journal-title":"Archives of biochemistry and biophysics"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.bbrc.2007.12.114","article-title":"The unique functions of cardiac troponin I in the control of cardiac muscle contraction and relaxation","volume":"369","author":"RJ Solaro","year":"2008","journal-title":"Biochemical and biophysical research communications"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1113\/jphysiol.2002.038117","article-title":"Troponin I in the murine myocardium: influence on length-dependent activation and interfilament spacing","volume":"547","author":"JP Konhilas","year":"2003","journal-title":"The Journal of Physiology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cardiores.2004.12.022","article-title":"Regulation of cardiac contractile function by troponin i phosphorylation","volume":"66","author":"J Layland","year":"2005","journal-title":"Cardiovascular Research"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0006-3495(93)81110-X","article-title":"Regulation of the interaction between actin and myosin subfragment 1: evidence for three states of the thin filament","volume":"65","author":"DF McKillop","year":"1993","journal-title":"Biophysical journal"},{"key":"ref32","unstructured":"Rice JJ, Tu Y, Poggesi C, De Tombe PP (2008) Spatially-compressed cardiac myofilament models generate hysteresis that is not found in real muscle. Pacific Symposium on Biocomputing: 366\u2013377."},{"key":"ref33","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.yjmcc.2006.06.003","article-title":"Mechanism of the frank-starling law\u2013a simulation study with a novel cardiac muscle contraction model that includes titin and troponin i","volume":"41","author":"NS Schneider","year":"2006","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1529\/biophysj.105.069534","article-title":"A quantitative analysis of cardiac myocyte relaxation: a simulation study","volume":"90","author":"SA Niederer","year":"2006","journal-title":"Biophysical journal"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1529\/biophysj.107.119487","article-title":"Approximate model of cooperative activation and crossbridge cycling in cardiac muscle using ordinary differential equations","volume":"95","author":"JJ Rice","year":"2008","journal-title":"Biophysical Journal"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"4553","DOI":"10.1113\/jphysiol.2012.231928","article-title":"An analysis of deformation-dependent electromechanical coupling in the mouse heart","volume":"590","author":"S Land","year":"2012","journal-title":"The Journal of Physiology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0006-3495(03)74907-8","article-title":"Ising model of cardiac thin filament activation with nearest-neighbor cooperative interactions","volume":"84","author":"JJ Rice","year":"2003","journal-title":"Biophysical Journal"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1016\/j.bpj.2010.02.010","article-title":"Coupling of adjacent tropomyosins enhances cross-bridge-mediated cooperative activation in a markov model of the cardiac thin filament","volume":"98","author":"SG Campbell","year":"2010","journal-title":"Biophysical Journal"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1172\/JCI61134","article-title":"Mouse and computational models link mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease","volume":"122","author":"F Sheikh","year":"2012","journal-title":"Journal of Clinical Investigation"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1016\/S0006-3495(03)70040-X","article-title":"Cooperative regulation of myosin-actin interactions by a continuous flexible chain I: Actin-tropomyosin systems","volume":"84","author":"D Smith","year":"2003","journal-title":"Biophysical Journal"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1016\/S0006-3495(03)70041-1","article-title":"Cooperative regulation of myosin-actin interactions by a continuous flexible chain II: actin-tropomyosin-troponin and regulation by calcium","volume":"84","author":"D Smith","year":"2003","journal-title":"Biophysical Journal"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1007\/s00249-012-0859-8","article-title":"Cooperative regulation of myosin-s1 binding to actin filaments by a continuous flexible Tm\u2013Tn chain","volume":"41","author":"SM Mijailovich","year":"2012","journal-title":"European Biophysics Journal"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.bpj.2013.06.044","article-title":"A mechanistic model of ca regulation of thin filaments in cardiac muscle","volume":"105","author":"NA Metalnikova","year":"2013","journal-title":"Biophysical Journal"},{"key":"ref44","article-title":"Mechanics of motor proteins and the cytoskeleton","author":"J Howard","year":"2001"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/S0006-3495(95)80316-4","article-title":"Myosin binding-induced cooperative activation of the thin filament in cardiac myocytes and skeletal muscle fibers","volume":"68","author":"JM Metzger","year":"1995","journal-title":"Biophysical Journal"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0022-2836(84)80010-8","article-title":"The thin filament of vertebrate skeletal muscle co-operatively activates as a unit","volume":"180","author":"PW Brandt","year":"1984","journal-title":"Journal of Molecular Biology"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1006\/jmbi.1996.0800","article-title":"Steric-model for activation of muscle thin filaments","volume":"266","author":"P Vibert","year":"1997","journal-title":"Journal of molecular biology"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jsb.2006.02.020","article-title":"A comparison of muscle thin filament models obtained from electron microscopy reconstructions and low-angle x-ray fibre diagrams from non-overlap muscle","volume":"155","author":"KJV Poole","year":"2006","journal-title":"Journal of Structural Biology"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.2741\/3444","article-title":"Insight into the actin-myosin motor from x-ray diffraction on muscle","volume":"14","author":"SY Bershitsky","year":"2009","journal-title":"Frontiers in Bioscience (Landmark Edition)"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"12607","DOI":"10.1073\/pnas.1309493110","article-title":"Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human \u03b2<\/italic>-cardiac myosin motor function","volume":"110","author":"RF Sommese","year":"2013","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0006-3495(00)76349-1","article-title":"ATP consumption and efficiency of human single muscle fibers with different myosin isoform composition","volume":"79","author":"ZH He","year":"2000","journal-title":"Biophysical Journal"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1161\/01.RES.77.1.199","article-title":"Osmotic compression of single cardiac myocytes eliminates the reduction in Ca2+ sensitivity of tension at short sarcomere length","volume":"77","author":"KS McDonald","year":"1995","journal-title":"Circ Res"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"H1055","DOI":"10.1152\/ajpheart.00667.2001","article-title":"Cooperative activation in cardiac muscle: impact of sarcomere length","volume":"282","author":"DP Dobesh","year":"2002","journal-title":"American Journal of Physiology\u2014Heart and Circulatory Physiology"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.yjmcc.2009.11.019","article-title":"The molecular basis of the steep force-calcium relation in heart muscle","volume":"48","author":"YB Sun","year":"2010","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1529\/biophysj.103.039123","article-title":"Cross-bridge versus thin filament contributions to the level and rate of force development in cardiac muscle","volume":"87","author":"M Regnier","year":"2004","journal-title":"Biophysical Journal"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"27930","DOI":"10.1074\/jbc.M111.337295","article-title":"The rates of ca2+ dissociation and cross-bridge detachment from ventricular myofibrils as reported by a fluorescent cardiac troponin c","volume":"287","author":"SC Little","year":"2012","journal-title":"Journal of Biological Chemistry"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1006\/jmcc.2002.2065","article-title":"Physiological determinants of contractile force generation and calcium handling in mouse myocardium","volume":"34","author":"LB Stull","year":"2002","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s00424-005-0020-y","article-title":"Murine strain differences in contractile function are temperature- and frequency-dependent","volume":"452","author":"LB Stull","year":"2006","journal-title":"Pfl\u00c3\u00bcgers Archiv\u2014European Journal of Physiology"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/S0008-6363(99)00109-1","article-title":"Overexpression of sarcoplasmic reticulum Ca2+\u2013ATPase improves cardiac contractile function in hypothyroid mice","volume":"43","author":"WF Bluhm","year":"1999","journal-title":"Cardiovascular Research"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"H249","DOI":"10.1152\/ajpheart.2000.278.1.H249","article-title":"Phospholamban: a major determinant of the cardiac force-frequency relationship","volume":"278","author":"WF Bluhm","year":"2000","journal-title":"American Journal of Physiology\u2014Heart and Circulatory Physiology"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1113\/jphysiol.2002.024430","article-title":"Effect of stimulation rate, sarcomere length and ca2+ on force generation by mouse cardiac muscle","volume":"544","author":"BD Stuyvers","year":"2002","journal-title":"The Journal of Physiology"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"H1487","DOI":"10.1152\/ajpheart.00443.2014","article-title":"Computational modeling of Takotsubo cardiomyopathy: effect of spatially varying \u03b2<\/italic>-adrenergic stimulation in the rat left ventricle","volume":"307","author":"S Land","year":"2014","journal-title":"American Journal of Physiology\u2014Heart and Circulatory Physiology"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1161\/01.CIR.85.5.1743","article-title":"Altered myocardial force-frequency relation in human heart failure","volume":"85","author":"LA Mulieri","year":"1992","journal-title":"Circulation"},{"key":"ref64","first-page":"764","article-title":"Diminished post-rest potentiation of contractile force in human dilated cardiomyopathy","volume":"98","author":"B Pieske","year":"1996","journal-title":"functional evidence for alterations in intracellular Ca2+ handling. Journal of Clinical Investigation"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/j.bpj.2013.01.042","article-title":"Beta-adrenergic stimulation maintains cardiac function in Serca2 knockout mice","volume":"104","author":"S Land","year":"2013","journal-title":"Biophysical Journal"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.yjmcc.2011.06.012","article-title":"Methods in cardiomyocyte isolation, culture, and gene transfer","volume":"51","author":"WE Louch","year":"2011","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1113\/jphysiol.2014.279232","article-title":"Quantifying inter-species differences in contractile function through biophysical modelling","volume":"593","author":"K T\u00c3\u00b8ndel","year":"2015","journal-title":"The Journal of Physiology"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1161\/CIRCULATIONAHA.112.134932","article-title":"Late sodium current inhibition reverses electromechanical dysfunction in human hypertrophic cardiomyopathy","volume":"127","author":"R Coppini","year":"2013","journal-title":"Circulation"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0079-6107(98)00013-3","article-title":"Modelling the mechanical properties of cardiac muscle","volume":"69","author":"PJ Hunter","year":"1998","journal-title":"Progress in biophysics and molecular biology"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1109\/TBME.2011.2112359","article-title":"Efficient computational methods for strongly coupled cardiac electromechanics","author":"S Land","year":"2012","journal-title":"Biomedical Engineering, IEEE Transactions on 59"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"H2732","DOI":"10.1152\/ajpheart.2001.280.6.H2732","article-title":"PKA accelerates rate of force development in murine skinned myocardium expressing \u03b1<\/italic>- or \u03b2<\/italic>-tropomyosin","volume":"280","author":"JR Patel","year":"2001","journal-title":"American Journal of Physiology\u2014Heart and Circulatory Physiology"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1085\/jgp.117.2.133","article-title":"Cooperative mechanisms in the activation dependence of the rate of force development in rabbit skinned skeletal muscle fibers","volume":"117","author":"DP Fitzsimons","year":"2001","journal-title":"The Journal of General Physiology"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1161\/01.RES.83.2.179","article-title":"Roles of Ca2+ and crossbridge kinetics in determining the maximum rates of Ca2+ activation and relaxation in rat and guinea pig skinned trabeculae","volume":"83","author":"S Palmer","year":"1998","journal-title":"Circulation Research"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1161\/01.RES.76.1.154","article-title":"Rate of tension development in cardiac muscle varies with level of activator calcium","volume":"76","author":"MR Wolff","year":"1995","journal-title":"Circulation Research"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1161\/01.RES.0000127125.61647.4F","article-title":"Myosin crossbridge activation of cardiac thin filaments implications for myocardial function in health and disease","volume":"94","author":"RL Moss","year":"2004","journal-title":"Circulation Research"},{"key":"ref76","first-page":"703","article-title":"Tension development and sarcomere length in rat cardiac trabeculae","volume":"46","author":"HE ter Keurs","year":"1980","journal-title":"evidence of length-dependent activation. Circulation Research"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1085\/jgp.200709895","article-title":"Troponin and titin coordinately regulate length-dependent activation in skinned porcine ventricular muscle","volume":"131","author":"T Terui","year":"2008","journal-title":"The Journal of General Physiology"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2174\/157340309788166714","article-title":"Titin and troponin: Central players in the frank-starling mechanism of the heart","volume":"5","author":"N Fukuda","year":"2009","journal-title":"Current Cardiology Reviews"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"H1171","DOI":"10.1152\/ajpheart.00580.2013","article-title":"Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation","volume":"306","author":"PJM Wijnker","year":"2014","journal-title":"American Journal of Physiology\u2014Heart and Circulatory Physiology"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1152\/jappl.1999.87.5.1861","article-title":"Stiffness-distortion sarcomere model for muscle simulation","volume":"87","author":"MV Razumova","year":"1999","journal-title":"J Appl Physiol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1085\/jgp.201010467","article-title":"Model representation of the nonlinear step response in cardiac muscle","volume":"136","author":"SJ Ford","year":"2010","journal-title":"The Journal of General Physiology"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1016\/j.bpj.2011.10.007","article-title":"Millisecond-scale biochemical response to change in strain","volume":"101","author":"DC Bickham","year":"2011","journal-title":"Biophysical Journal"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.1016\/S0006-3495(00)76849-4","article-title":"Different Myofilament Nearest-Neighbor Interactions Have Distinctive Effects on Contractile Behavior","volume":"78","author":"MV Razumova","year":"2000","journal-title":"Biophysical Journal"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0006-3495(95)79889-7","article-title":"Steady-state [Ca2+]i-force relationship in intact twitching cardiac muscle: direct evidence for modulation by isoproterenol and EMD 53998","volume":"69","author":"LE Dobrunz","year":"1995","journal-title":"Biophysical Journal"}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1004376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T05:51:43Z","timestamp":1653025903000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1004376"}},"subtitle":[],"editor":[{"given":"Daniel A","family":"Beard","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2015,8,11]]},"references-count":84,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2015,8,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1004376","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,11]]}}}