{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T21:53:59Z","timestamp":1722203639748},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Imaging"],"abstract":"Abstract<\/jats:title>\n Background<\/jats:title>\n Although the central scar is an essential imaging characteristic of renal oncocytoma (RO), its utility in distinguishing RO from renal cell carcinoma (RCC) has not been well explored. The study aimed to evaluate whether the combination of CT characteristics of the peripheral tumor parenchyma (PTP) and central hypodense area (CHA) can differentiate typical RO with CHA from RCC.<\/jats:p>\n <\/jats:sec>\n Methods<\/jats:title>\n A total of 132 tumors on the initial dataset were retrospectively evaluated using four-phase CT. The excretory phases were performed more than 20\u00a0min after the contrast injection. In corticomedullary phase (CMP) images, all tumors had CHAs. These tumors were categorized into RO (n<\/jats:italic>\u2009=\u200923), clear cell RCC (ccRCC) (n<\/jats:italic>\u2009=\u200985), and non-ccRCC (n<\/jats:italic>\u2009=\u200924) groups. The differences in these qualitative and quantitative CT features of CHA and PTP between ROs and ccRCCs\/non-ccRCCs were statistically examined. Logistic regression filters the main factors for separating ROs from ccRCCs\/non-ccRCCs. The prediction models omitting and incorporating CHA features were constructed and evaluated, respectively. The effectiveness of the prediction models including CHA characteristics was then confirmed through a validation dataset (8 ROs, 35 ccRCCs, and 10 non-ccRCCs).<\/jats:p>\n <\/jats:sec>\n Results<\/jats:title>\n The findings indicate that for differentiating ROs from ccRCCs and non-ccRCCs, prediction models with CHA characteristics surpassed models without CHA, with the corresponding areas under the curve (AUC) being 0.962 and 0.914 versus 0.952 and 0.839 respectively. In the prediction models that included CHA parameters, the relative enhancement ratio (RER) in CMP and enhancement inversion, as well as RER in nephrographic phase and enhancement inversion were the primary drivers for differentiating ROs from ccRCCs and non-ccRCCs, respectively. The prediction models with CHA characteristics had the comparable diagnostic ability on the validation dataset, with respective AUC values of 0.936 and 0.938 for differentiating ROs from ccRCCs and non-ccRCCs.<\/jats:p>\n <\/jats:sec>\n Conclusion<\/jats:title>\n The prediction models with CHA characteristics can help better differentiate typical ROs from RCCs. When a mass with CHA is discovered, particularly if RO is suspected, EP images with longer delay scanning periods should be acquired to evaluate the enhancement inversion characteristics of CHA.<\/jats:p>\n <\/jats:sec>","DOI":"10.1186\/s12880-023-00972-0","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T11:02:58Z","timestamp":1674817378000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["CT differentiation of the oncocytoma and renal cell carcinoma based on peripheral tumor parenchyma and central hypodense area characterisation"],"prefix":"10.1186","volume":"23","author":[{"given":"Jianyi","family":"Qu","sequence":"first","affiliation":[]},{"given":"Qianqian","family":"Zhang","sequence":"additional","affiliation":[]},{"given":"Xinhong","family":"Song","sequence":"additional","affiliation":[]},{"given":"Hong","family":"Jiang","sequence":"additional","affiliation":[]},{"given":"Heng","family":"Ma","sequence":"additional","affiliation":[]},{"given":"Wenhua","family":"Li","sequence":"additional","affiliation":[]},{"given":"Xiaofei","family":"Wang","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2023,1,27]]},"reference":[{"key":"972_CR1","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s13244-014-0373-x","volume":"6","author":"K Ishigami","year":"2015","unstructured":"Ishigami K, Jones AR, Dahmoush L, Leite LV, Pakalniskis MG, Barloon TJ. 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