{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T07:35:48Z","timestamp":1725780948340},"reference-count":59,"publisher":"MIT Press - Journals","issue":"2","content-domain":{"domain":["direct.mit.edu"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,2,1]]},"abstract":"Abstract<\/jats:title>\n Neuropsychological and functional imaging studies have associated the conceptual processing of numbers with bilateral parietal regions (including intraparietal sulcus). However, the processes driving these effects remain unclear because both left and right posterior parietal regions are activated by many other conceptual, perceptual, attention, and response-selection processes. To dissociate parietal activation that is number-selective from parietal activation related to other stimulus or response-selection processes, we used fMRI to compare numbers and object names during exactly the same conceptual and perceptual tasks while factoring out activations correlating with response times. We found that right parietal activation was higher for conceptual decisions on numbers relative to the same tasks on object names, even when response time effects were fully factored out. In contrast, left parietal activation for numbers was equally involved in conceptual processing of object names. We suggest that left parietal activation for numbers reflects a range of processes, including the retrieval of learnt facts that are also involved in conceptual decisions on object names. In contrast, number selectivity in right parietal cortex reflects processes that are more involved in conceptual decisions on numbers than object names. Our results generate a new set of hypotheses that have implications for the design of future behavioral and functional imaging studies of patients with left and right parietal damage.<\/jats:p>","DOI":"10.1162\/jocn.2009.21246","type":"journal-article","created":{"date-parts":[[2009,4,28]],"date-time":"2009-04-28T14:43:40Z","timestamp":1240929820000},"page":"331-346","update-policy":"http:\/\/dx.doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":68,"title":["The Role of Right and Left Parietal Lobes in the Conceptual Processing of Numbers"],"prefix":"10.1162","volume":"22","author":[{"given":"Marinella","family":"Cappelletti","sequence":"first","affiliation":[{"name":"1University College London, UK"}]},{"given":"Hwee Ling","family":"Lee","sequence":"additional","affiliation":[{"name":"2Max Planck Institute for Biological Cybernetics, T\u00fcbingen, Germany"}]},{"given":"Elliot D.","family":"Freeman","sequence":"additional","affiliation":[{"name":"1University College London, UK"},{"name":"3Brunel University, Uxbridge, UK"}]},{"given":"Cathy J.","family":"Price","sequence":"additional","affiliation":[{"name":"1University College London, UK"}]}],"member":"281","published-online":{"date-parts":[[2010,2,1]]},"reference":[{"key":"2021072900373938800_R1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.cogbrainres.2005.06.002","article-title":"Hemispheric lateralization of number comparison.","volume":"25","author":"Andres","year":"2005","journal-title":"Cognitive Brain Research"},{"key":"2021072900373938800_R2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.brainres.2005.10.083","article-title":"Parametric effects of numerical distance on the intraparietal sulcus during passive viewing of rapid numerosity changes.","volume":"1067","author":"Ansari","year":"2006","journal-title":"Brain Research"},{"key":"2021072900373938800_R3","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1006\/nimg.2002.1252","article-title":"Dissociable contribution of prefrontal and parietal cortices to responses selection.","volume":"17","author":"Bunge","year":"2002","journal-title":"Neuroimage"},{"key":"2021072900373938800_R4","doi-asserted-by":"crossref","first-page":"e125","DOI":"10.1371\/journal.pbio.0040125","article-title":"Functional imaging of numerical processing in adults and 4-y-old children.","volume":"4","author":"Cantlon","year":"2006","journal-title":"PLoS Biology"},{"key":"2021072900373938800_R5","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s00221-006-0820-0","article-title":"rTMS over the left and the right intraparietal sulcus disrupts discrete and continuous quantity processing.","volume":"179","author":"Cappelletti","year":"2007","journal-title":"Experimental Brain Research"},{"key":"2021072900373938800_R6","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.cortex.2006.07.005","article-title":"A case of selective impairment of encyclopaedic numerical knowledge or \u201cwhen December 25th is no longer Christmas day, but \u201820 + 5\u2019 is still 25\u201d.","volume":"3","author":"Cappelletti","year":"2008","journal-title":"Cortex"},{"key":"2021072900373938800_R7","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.neuroimage.2009.02.016","article-title":"Quantity without numbers and numbers without quantity in the parietal cortex.","volume":"46","author":"Cappelletti","year":"2009","journal-title":"Neuroimage"},{"key":"2021072900373938800_R66","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.1073\/pnas.0600444103","article-title":"Discrete and analogue quantity processing in the parietal lobe: A functional MRI study.","volume":"103, 12","author":"Castelli","year":"2006","journal-title":"Proceedings of the National Academy of Sciences, U.S.A."},{"key":"2021072900373938800_R8","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1162\/089892999563689","article-title":"Differential contributions of the left and right inferior parietal lobules to number processing.","volume":"11","author":"Chochon","year":"1999","journal-title":"Journal of Cognitive Neuroscience"},{"key":"2021072900373938800_R9","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1093\/brain\/114.6.2619","article-title":"A specific deficit for numbers in a case of dense acalculia.","volume":"114","author":"Cipolotti","year":"1991","journal-title":"Brain"},{"key":"2021072900373938800_R11","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/cercor\/bhm058","article-title":"When brightness counts: The neuronal correlate of numerical\u2013luminance interference.","volume":"18","author":"Cohen Kadosh","year":"2008","journal-title":"Cerebral Cortex"},{"key":"2021072900373938800_R12","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.neuron.2006.12.025","article-title":"Notation-dependent and -independent representations of numbers in the parietal lobes.","volume":"53","author":"Cohen Kadosh","year":"2007","journal-title":"Neuron"},{"key":"2021072900373938800_R14","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.pneurobio.2007.11.001","article-title":"Are numbers special? An overview of chronometric, neuroimaging, developmental and comparative studies of magnitude representation.","volume":"84","author":"Cohen Kadosh","year":"2008","journal-title":"Progress in Neurobiology"},{"key":"2021072900373938800_R15","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nrn755","article-title":"Control of goal-directed and stimulus-driven attention in the brain.","volume":"3","author":"Corbetta","year":"2002","journal-title":"Nature Reviews Neuroscience"},{"key":"2021072900373938800_R16","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/S0926-6410(03)00138-1","article-title":"Distinct neural substrates for visual search amongst spatial versus temporal distracters.","volume":"17","author":"Coull","year":"2003","journal-title":"Cognitive Brain Research"},{"key":"2021072900373938800_R17","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0959-4388(00)00191-4","article-title":"Neuroimaging of cognitive functions in human parietal cortex.","volume":"11","author":"Culham","year":"2001","journal-title":"Current Opinion in Neurobiology"},{"key":"2021072900373938800_R18","volume-title":"The number sense.","author":"Dehaene","year":"1998"},{"key":"2021072900373938800_R19","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/0028-3932(91)90076-K","article-title":"Two mental calculation systems: A case study of severe acalculia with preserved approximation.","volume":"29","author":"Dehaene","year":"1991","journal-title":"Neuropsychologia"},{"key":"2021072900373938800_R20","first-page":"83","article-title":"Towards an anatomical and functional model of number processing.","volume":"1","author":"Dehaene","year":"1995","journal-title":"Mathematical Cognition"},{"key":"2021072900373938800_R22","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1080\/02643290244000239","article-title":"Three parietal circuits for number processing.","volume":"20","author":"Dehaene","year":"2003","journal-title":"Cognitive Neuropsychology"},{"key":"2021072900373938800_R23","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1126\/science.284.5416.970","article-title":"Sources of mathematical thinking: Behavioral and brain-imaging evidence.","volume":"284","author":"Dehaene","year":"1999","journal-title":"Science"},{"key":"2021072900373938800_R24","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/0028-3932(96)00027-9","article-title":"Cerebral activations during number multiplication and comparison: A PET study.","volume":"34","author":"Dehaene","year":"1996","journal-title":"Neuropsychologia"},{"key":"2021072900373938800_R25","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0010-9452(08)70727-5","article-title":"Arithmetic facts without meaning.","volume":"33","author":"Delazer","year":"1997","journal-title":"Cortex"},{"key":"2021072900373938800_R26","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0896-6273(03)00036-9","article-title":"A supramodal number representation in human intraparietal cortex.","volume":"37","author":"Eger","year":"2003","journal-title":"Neuron"},{"key":"2021072900373938800_R28","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1162\/089892903321107819","article-title":"Parietal representation of symbolic and non-symbolic magnitude.","volume":"15","author":"Fias","year":"2003","journal-title":"Journal of Cognitive Neuroscience"},{"key":"2021072900373938800_R29","first-page":"401","article-title":"Neuronal transients.","volume":"22","author":"Friston","year":"1995","journal-title":"Proceedings of the Royal Society of London, Series B, Biological Sciences"},{"key":"2021072900373938800_R30","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1006\/nimg.1999.0498","article-title":"Stochastic designs in event-related fMRI.","volume":"10","author":"Friston","year":"1999","journal-title":"Neuroimage"},{"key":"2021072900373938800_R32","doi-asserted-by":"crossref","first-page":"B87","DOI":"10.1016\/S0010-0277(02)00234-2","article-title":"The mental representation of ordinal sequences is spatially organized.","volume":"87","author":"Gevers","year":"2003","journal-title":"Cognition"},{"key":"2021072900373938800_R33","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1162\/0898929042568442","article-title":"Response-selection related parietal activation during number comparison.","volume":"16","author":"G\u00f6bel","year":"2004","journal-title":"Journal of Cognitive Neuroscience"},{"key":"2021072900373938800_R34","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.tics.2005.11.006","article-title":"Repetition and the brain: Neural models of stimulus-specific effects.","volume":"10","author":"Grill-Spector","year":"2006","journal-title":"Trends in Cognitive Sciences"},{"key":"2021072900373938800_R35","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1002\/hbm.20433","article-title":"Are numbers special? Comparing the generation of verbal materials from ordered categories (months) to numbers and other categories (animals) in an fMRI study.","volume":"29","author":"Ischebeck","year":"2007","journal-title":"Human Brain Mapping"},{"key":"2021072900373938800_R36","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1371\/journal.pbio.0060011","article-title":"Distinct cerebral pathways for object identity and number in human infants.","volume":"6","author":"Izard","year":"2008","journal-title":"PLoS Biology"},{"key":"2021072900373938800_R67","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1744-9081-2-31","article-title":"Impaired neural networks for approximate calculation in dyscalculic children: A fMRI study.","volume":"2","author":"Kucian","year":"2006","journal-title":"Behavior and Brain Function"},{"key":"2021072900373938800_R37","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1006\/nimg.2000.0627","article-title":"Distinct cortical areas for names of numbers and body parts independent of language and input modality.","volume":"12","author":"Le Clec'H","year":"2000","journal-title":"Neuroimage"},{"key":"2021072900373938800_R38","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1016\/S0028-3932(03)00123-4","article-title":"Approximate quantities and exact number words: Dissociable systems.","volume":"41","author":"Lemer","year":"2003","journal-title":"Neuropsychologia"},{"key":"2021072900373938800_R39","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S0896-6273(03)00670-6","article-title":"Functional and structural alterations of the intraparietal sulcus in a developmental dyscalculia of genetic origin.","volume":"40","author":"Molko","year":"2003","journal-title":"Neuron"},{"key":"2021072900373938800_R40","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1093\/cercor\/11.10.966","article-title":"The priming method: Imaging unconscious repetition priming reveals an abstract representation of number in the parietal lobes.","volume":"11","author":"Naccache","year":"2001","journal-title":"Cerebral Cortex"},{"key":"2021072900373938800_R41","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nrn1626","article-title":"Counting on neurons: The neurobiology of numerical competence.","volume":"6","author":"Nieder","year":"2005","journal-title":"Nature Neuroscience Review"},{"key":"2021072900373938800_R42","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1162\/089892900562273","article-title":"Neuroanatomical substrates of Arabic number processing, numerical comparison, and simple addition: A PET study.","volume":"12","author":"Pesenti","year":"2000","journal-title":"Journal of Cognitive Neuroscience"},{"key":"2021072900373938800_R43","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.neuron.2004.10.014","article-title":"Tuning curves for approximate numerosity in the human intraparietal sulcus.","volume":"44","author":"Piazza","year":"2004","journal-title":"Neuron"},{"key":"2021072900373938800_R44","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.neuron.2006.11.022","article-title":"Magnitude code common to numerosities and number symbols in human intraparietal cortex.","volume":"53","author":"Piazza","year":"2007","journal-title":"Neuron"},{"key":"2021072900373938800_R45","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1006\/nimg.2001.0913","article-title":"Modulation of parietal activation by semantic distance in a number comparison task.","volume":"14","author":"Pinel","year":"2001","journal-title":"Neuroimage"},{"key":"2021072900373938800_R68","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1006\/nimg.2001.0913","article-title":"Modulation of parietal activation by semantic distance in a number comparison task.","volume":"14","author":"Pinel","year":"1999","journal-title":"Neuroimage"},{"key":"2021072900373938800_R46","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0896-6273(04)00107-2","article-title":"Distributed and overlapping cerebral representations of number, size, and luminance during comparative judgments.","volume":"41","author":"Pinel","year":"2004","journal-title":"Neuron"},{"key":"2021072900373938800_R48","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1006\/brcg.2001.1486","article-title":"A dissociation between symbolic number knowledge and analogue magnitude information.","volume":"47","author":"Polk","year":"2001","journal-title":"Brain and Cognition"},{"key":"2021072900373938800_R49","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S1053-8119(02)00036-8","article-title":"Separating distracter rejection and target detection in posterior parietal cortex\u2014An event-related fMRI study of visual marking.","volume":"18","author":"Pollmann","year":"2003","journal-title":"Neuroimage"},{"key":"2021072900373938800_R50","first-page":"R1042","article-title":"Impaired parietal magnitude processing in developmental dyscalculia.","volume":"17, 24","author":"Price","year":"2008","journal-title":"Current Biology"},{"key":"2021072900373938800_R51","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1162\/jocn.2006.18.4.680","article-title":"Explicit versus implicit processing of representational space in neglect: Dissociations in accessing the mental number line.","volume":"18","author":"Priftis","year":"2006","journal-title":"Journal of Cognitive Neuroscience"},{"key":"2021072900373938800_R52","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1162\/089892900562129","article-title":"Motor area activity during mental rotation studied by time-resolved single-trial fMRI.","volume":"12","author":"Richter","year":"2000","journal-title":"Journal of Cognitive Neuroscience"},{"key":"2021072900373938800_R54","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.neuroimage.2007.08.045","article-title":"Optimized voxel-based morphometry in children with developmental dyscalculia.","volume":"39","author":"Rotzer","year":"2008","journal-title":"Neuroimage"},{"key":"2021072900373938800_R55","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.neuron.2004.10.008","article-title":"Numerical magnitude in the human parietal lobe: Tests of representational generality and domain specificity.","volume":"44","author":"Shuman","year":"2004","journal-title":"Neuron"},{"key":"2021072900373938800_R56","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0896-6273(02)00575-5","article-title":"Topographical layout of hand, eye, calculation and language related areas in the human parietal lobe.","volume":"33","author":"Simon","year":"2002","journal-title":"Neuron"},{"key":"2021072900373938800_R69","first-page":"2240","article-title":"Cerebral bases of calculation processes: Impact of number size on the cerebral circuits for exact and approximate calculation.","volume":"123","author":"Stanescu","year":"2000","journal-title":"Brain"},{"key":"2021072900373938800_R58","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1162\/jocn.2006.18.12.2049","article-title":"Imaging informational conflict: An fMRI study of numerical Stroop.","volume":"18","author":"Tang","year":"2006","journal-title":"Journal of Cognitive Neuroscience"},{"key":"2021072900373938800_R59","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.cogbrainres.2005.02.009","article-title":"Task independent semantic activation for numbers and animals.","volume":"24","author":"Thioux","year":"2005","journal-title":"Cognitive Brain Research"},{"key":"2021072900373938800_R62","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0010-9452(08)70134-5","article-title":"The number space and neglect.","volume":"40","author":"Vuilleumier","year":"2004","journal-title":"Cortex"},{"key":"2021072900373938800_R63","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0896-6273(01)80033-7","article-title":"The generality of parietal involvement in visual attention.","volume":"23","author":"Wojciulik","year":"1999","journal-title":"Neuron"},{"key":"2021072900373938800_R64","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.neuropsychologia.2005.10.025","article-title":"The spatial representation of numerical and non-numerical sequences: Evidence from neglect.","volume":"44","author":"Zorzi","year":"2006","journal-title":"Neuropsychologia"},{"key":"2021072900373938800_R65","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/417138a","article-title":"Brain damage: Neglect disrupts the mental number line.","volume":"417","author":"Zorzi","year":"2002","journal-title":"Nature"}],"container-title":["Journal of Cognitive Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/direct.mit.edu\/jocn\/article-pdf\/22\/2\/331\/1938600\/jocn.2009.21246.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/direct.mit.edu\/jocn\/article-pdf\/22\/2\/331\/1938600\/jocn.2009.21246.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:40:23Z","timestamp":1627519223000},"score":1,"resource":{"primary":{"URL":"https:\/\/direct.mit.edu\/jocn\/article\/22\/2\/331\/4801\/The-Role-of-Right-and-Left-Parietal-Lobes-in-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,1]]},"references-count":59,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2010,2,1]]},"published-print":{"date-parts":[[2010,2,1]]}},"URL":"https:\/\/doi.org\/10.1162\/jocn.2009.21246","relation":{},"ISSN":["0898-929X","1530-8898"],"issn-type":[{"value":"0898-929X","type":"print"},{"value":"1530-8898","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2010,2]]},"published":{"date-parts":[[2010,2,1]]}}}