{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T15:29:14Z","timestamp":1679671754576},"reference-count":34,"publisher":"World Scientific Pub Co Pte Lt","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Bioinform. Comput. Biol."],"published-print":{"date-parts":[[2007,12]]},"abstract":"Recently, a number of collaborative large-scale mouse mutagenesis programs have been launched. These programs aim for a better understanding of the roles of all individual coding genes and the biological systems in which these genes participate. In international efforts to share phenotypic data among facilities\/institutes, it is desirable to integrate information obtained from different phenotypic platforms reliably. Since the definitions of specific phenotypes often depend on a tacit understanding of concepts that tends to vary among different facilities, it is necessary to define phenotypes based on the explicit evidence of assay results. We have developed a website termed PhenoSITE (Phenome Semantics Information with Terminology of Experiments: ), in which we are trying to integrate phenotype-related information using an experimental-evidence\u2013based approach. The site's features include (1) a baseline database for our phenotyping platform; (2) an ontology associating international phenotypic definitions with experimental terminologies used in our phenotyping platform; (3) a database for standardized operation procedures of the phenotyping platform; and (4) a database for mouse mutants using data produced from the large-scale mutagenesis program at RIKEN GSC. We have developed two types of integrated viewers to enhance the accessibility to mutant resource information. One viewer depicts a matrix view of the ontology-based classification and chromosomal location of each gene; the other depicts ontology-mediated integration of experimental protocols, baseline data, and mutant information. These approaches rely entirely upon experiment-based evidence, ensuring the reliability of the integrated data from different phenotyping platforms.<\/jats:p>","DOI":"10.1142\/s0219720007003168","type":"journal-article","created":{"date-parts":[[2007,12,31]],"date-time":"2007-12-31T05:56:01Z","timestamp":1199080561000},"page":"1173-1191","source":"Crossref","is-referenced-by-count":10,"title":["PHENOSITE: A WEB DATABASE INTEGRATING THE MOUSE PHENOTYPING PLATFORM AND THE EXPERIMENTAL PROCEDURES IN MICE"],"prefix":"10.1142","volume":"05","author":[{"given":"HIROSHI","family":"MASUYA","sequence":"first","affiliation":[{"name":"Mouse Functional Genomics Research Group, RIKEN GSC, 3-1-1 Kouyadai, Tsukuba, Ibaraki 305-0074, Japan"}]},{"given":"SUMI","family":"YOSHIKAWA","sequence":"additional","affiliation":[{"name":"Advanced Genome Information Technology Research Group, RIKEN GSC, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama City, Kanagawa 230-0045, Japan"}]},{"given":"NAOHIKO","family":"HEIDA","sequence":"additional","affiliation":[{"name":"Integrative Omics Research Team, RIKEN GSC, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama City, Kanagawa 230-0045, Japan"}]},{"given":"TETSURO","family":"TOYODA","sequence":"additional","affiliation":[{"name":"Integrative Omics Research Team, RIKEN GSC, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama City, Kanagawa 230-0045, Japan"}]},{"given":"SHIGEHARU","family":"WAKANA","sequence":"additional","affiliation":[{"name":"Mouse Functional Genomics Research Group, RIKEN GSC, 3-1-1 Kouyadai, Tsukuba, Ibaraki 305-0074, Japan"}]},{"given":"TOSHIHIKO","family":"SHIROISHI","sequence":"additional","affiliation":[{"name":"Mouse Functional Genomics Research Group, RIKEN GSC, 3-1-1 Kouyadai, Tsukuba, Ibaraki 305-0074, Japan"}]}],"member":"219","published-online":{"date-parts":[[2011,11,21]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0904-921"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0904-925"},{"key":"rf3","doi-asserted-by":"publisher","DOI":"10.1126\/science.312.5782.1863"},{"key":"rf4","first-page":"9","volume":"128","author":"Collins F. 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