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We offer a theoretical conception of the IS artifact by drawing upon General Systems Theory (GST). Key concepts of GST are distilled as meta\u2010principles which inform our formulation of the IS artifact. We use the meta\u2010principles of the IS artifact to develop salient assertions that theorize what an \u2018IS\u2019 is. To demonstrate the appropriateness of our conception, we illustrate how the assertions we developed are consistent with patterns related to emerging topics in IS research, notably, healthcare and IT, and Fintech. We formulate a research agenda on these emerging topics\u2014based upon the conceptions developed in the paper\u2014to guide future research. We conclude with the contributions and implications of our study, including the relevance for IT\u2010enabled work in the era of the COVID\u201019 pandemic.<\/jats:p>","DOI":"10.1111\/isj.12320","type":"journal-article","created":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T07:46:48Z","timestamp":1609228008000},"page":"550-578","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["A possible conceptualization of the information systems (IS<\/scp>) artifact: A general systems theory perspective1<\/sup>"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"http:\/\/orcid.org\/0000-0001-8956-220X","authenticated-orcid":false,"given":"Sutirtha","family":"Chatterjee","sequence":"first","affiliation":[{"name":"Department of Management, Entrepreneurship, and Technology University of Nevada Las Vegas Nevada USA"}]},{"given":"Suprateek","family":"Sarker","sequence":"additional","affiliation":[{"name":"McIntire School of Commerce University of Virginia Charlottesville Virginia USA"}]},{"ORCID":"http:\/\/orcid.org\/0000-0002-8371-8928","authenticated-orcid":false,"given":"Michael J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Management, Entrepreneurship, and Technology University of Nevada Las Vegas Nevada USA"}]},{"given":"Xiao","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Digitalization Copenhagen Business School Frederiksberg Denmark"}]},{"given":"Amany","family":"Elbanna","sequence":"additional","affiliation":[{"name":"Reader of Information Systems Royal Holloway, University of London Egham UK"}]}],"member":"311","published-online":{"date-parts":[[2020,12,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1287\/mnsc.17.11.661"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1287\/isre.2016.0686"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1287\/isre.2014.0546"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2307\/25148689"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1287\/isre.2015.0595"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2307\/248961"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1057\/jit.2013.10"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.17705\/1jais.00245"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1287\/mnsc.1110.1438"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2753\/MIS0742-1222270109"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.17705\/1jais.00323"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/isj.12048"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1145\/357830.357849"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.17705\/1jais.00266"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.2307\/23044053"},{"issue":"1","key":"e_1_2_10_17_1","first-page":"185","article-title":"Connecting systems, data, and people: A multidisciplinary research roadmap for chronic disease management","volume":"44","author":"Bardhan I.","year":"2020","journal-title":"MIS Quarterly"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-45708-5_15"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/asi.23459"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/info11020071"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.17705\/1jais.00330"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.2307\/30036527"},{"issue":"1","key":"e_1_2_10_23_1","first-page":"1","article-title":"Complexity and information systems research in the emerging digital world","volume":"44","author":"Benbya H.","year":"2020","journal-title":"MIS Quarterly"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.17705\/1jais.00541"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.infoandorg.2016.11.002"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1287\/orsc.1070.0304"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1287\/mnsc.2.3.197"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.1699952"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.1721463"},{"key":"e_1_2_10_30_1","volume-title":"Competing on the edge: Strategy as structured chaos","author":"Brown S. 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