{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T18:47:20Z","timestamp":1732042040138},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union's Horizon 2020","award":["778247"]},{"name":"Italian Ministry of University and Research","award":["2017483NH8"]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,6]]},"abstract":"Abstract<\/jats:title>The MobiDB database (URL: https:\/\/mobidb.org\/) is a knowledge base of intrinsically disordered proteins. MobiDB aggregates disorder annotations derived from the literature and from experimental evidence along with predictions for all known protein sequences. MobiDB generates new knowledge and captures the functional significance of disordered regions by processing and combining complementary sources of information. Since its first release 10 years ago, the MobiDB database has evolved in order to improve the quality and coverage of\u00a0protein\u00a0disorder annotations and its accessibility. MobiDB has now reached its maturity in terms of data standardization and visualization. Here, we present a new release which focuses on the optimization of user experience and database content. The major advances compared to the previous version are the integration of AlphaFoldDB predictions and the re-implementation of the homology transfer pipeline, which expands manually curated annotations by two orders of magnitude. Finally, the entry page has been restyled in order to provide an overview of the available annotations along with two separate views that highlight structural disorder evidence and functions associated with different binding modes.<\/jats:p>","DOI":"10.1093\/nar\/gkac1065","type":"journal-article","created":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T11:12:22Z","timestamp":1669201942000},"page":"D438-D444","source":"Crossref","is-referenced-by-count":89,"title":["MobiDB: 10\u00a0years of intrinsically disordered proteins"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"http:\/\/orcid.org\/0000-0001-8210-2390","authenticated-orcid":false,"given":"Damiano","family":"Piovesan","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, University of Padova , Padova, Italy"}]},{"given":"Alessio","family":"Del\u00a0Conte","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Padova , Padova, Italy"}]},{"given":"Damiano","family":"Clementel","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Padova , Padova, Italy"}]},{"ORCID":"http:\/\/orcid.org\/0000-0003-0362-8218","authenticated-orcid":false,"given":"Alexander\u00a0Miguel","family":"Monzon","sequence":"additional","affiliation":[{"name":"Department of Information Engineering, University of Padova , Padova, Italy"}]},{"given":"Martina","family":"Bevilacqua","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Padova , Padova, Italy"}]},{"given":"Maria\u00a0Cristina","family":"Aspromonte","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Padova , Padova, Italy"}]},{"given":"Javier\u00a0A","family":"Iserte","sequence":"additional","affiliation":[{"name":"Bioinformatics Unit, Fundaci\u00f3n Instituto Leloir , Buenos Aires , Argentina"}]},{"given":"Fernando E","family":"Orti","sequence":"additional","affiliation":[{"name":"Bioinformatics Unit, Fundaci\u00f3n Instituto Leloir , Buenos Aires , Argentina"}]},{"ORCID":"http:\/\/orcid.org\/0000-0002-6564-1920","authenticated-orcid":false,"given":"Cristina","family":"Marino-Buslje","sequence":"additional","affiliation":[{"name":"Bioinformatics Unit, Fundaci\u00f3n Instituto Leloir , Buenos Aires , Argentina"}]},{"ORCID":"http:\/\/orcid.org\/0000-0003-4525-7793","authenticated-orcid":false,"given":"Silvio\u00a0C E","family":"Tosatto","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Padova , Padova, Italy"}]}],"member":"286","published-online":{"date-parts":[[2022,11,23]]},"reference":[{"key":"2023010804222290800_B1","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.1016\/j.febslet.2005.03.072","article-title":"The interplay between structure and function in intrinsically unstructured proteins","volume":"579","author":"Tompa","year":"2005","journal-title":"FEBS Lett."},{"key":"2023010804222290800_B2","doi-asserted-by":"crossref","first-page":"6589","DOI":"10.1021\/cr400525m","article-title":"Classification of intrinsically disordered regions and proteins","volume":"114","author":"van\u00a0der\u00a0Lee","year":"2014","journal-title":"Chem. 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