{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T05:56:21Z","timestamp":1668232581220},"reference-count":34,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T00:00:00Z","timestamp":1668124800000},"content-version":"vor","delay-in-days":314,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32270710"],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91949109"],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,11]]},"abstract":"Abstract<\/jats:title>\n Fibrosis is a common and serious disease that exists as a complicated impairment in many organs and triggers a complex cascade of responses. The deregulation of Ribonucleic Acids (RNAs) plays important roles in a variety of organ fibrosis cases. However, for fibrotic diseases, there is still a lack of an integrated platform with up-to-date information on RNA deregulation and high-throughput data. The Fibrotic Disease\u2013associated RNAome database (FDRdb) (http:\/\/www.medsysbio.org\/FDRdb) is a manually curated database of fibrotic disease\u2013associated RNAome information and high-throughput datasets. This initial release (i) contains 1947 associations between 912 RNAs and 92 fibrotic diseases in eight species; (ii) collects information on 764 datasets of fibrotic diseases; (iii) provides a user-friendly web interface that allows users to browse, search and download the RNAome information on fibrotic diseases and high-throughput datasets and (iv) provides tools to analyze the expression profiles of fibrotic diseases, including differential expression analysis and pathway enrichment. The FDRdb is a valuable resource for researchers to explore the mechanisms of RNA dysregulation in organ fibrosis.<\/jats:p>\n Database URL: http:\/\/www.medsysbio.org\/FDRdb<\/jats:p>","DOI":"10.1093\/database\/baac095","type":"journal-article","created":{"date-parts":[[2022,10,15]],"date-time":"2022-10-15T12:34:32Z","timestamp":1665837272000},"source":"Crossref","is-referenced-by-count":0,"title":["FDRdb: a manually curated database of fibrotic disease\u2013associated RNAome and high-throughput datasets"],"prefix":"10.1093","volume":"2022","author":[{"given":"Chengyu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University , Baojian Road, Nangang District, Harbin, Heilongjiang 150086, China"},{"name":"Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical Sciences , Wuhan University, Donghu Road, Wuchang District, Wuhan 430071, China"}]},{"given":"Tingting","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University , Baojian Road, Nangang District, Harbin, Heilongjiang 150086, China"}]},{"given":"Yuchen","family":"Mu","sequence":"additional","affiliation":[{"name":"Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University , Baojian Road, Nangang District, Harbin, Heilongjiang 150086, China"}]},{"given":"Xuan","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University , Baojian Road, Nangang District, Harbin, Heilongjiang 150086, China"}]},{"given":"Kai","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University , Baojian Road, Nangang District, Harbin, Heilongjiang 150086, China"}]},{"given":"Liqiang","family":"Ai","sequence":"additional","affiliation":[{"name":"Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University , Baojian Road, Nangang District, Harbin, Heilongjiang 150086, China"}]},{"ORCID":"http:\/\/orcid.org\/0000-0001-5693-4126","authenticated-orcid":false,"given":"Yunyan","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University , Baojian Road, Nangang District, Harbin, Heilongjiang 150086, China"}]},{"given":"Xingxing","family":"Fan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine\/Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology , Avenida WaiLong,Taipa, Macau (SAR) 999078, China"}]},{"given":"Haihai","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University , Baojian Road, Nangang District, Harbin, Heilongjiang 150086, China"}]}],"member":"286","published-online":{"date-parts":[[2022,11,11]]},"reference":[{"key":"2022111111391095900_R1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41575-020-00372-7","article-title":"Molecular and cellular mechanisms of liver fibrosis and its regression","volume":"18","author":"Kisseleva","year":"2021","journal-title":"Nat. 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