{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T15:15:22Z","timestamp":1717168522941},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T00:00:00Z","timestamp":1571011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"DHHS","doi-asserted-by":"publisher","award":["HHSN272201400028C"],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"Abstract<\/jats:title>\n \n Motivation<\/jats:title>\n Sequence repositories have few well-annotated virus mature peptide sequences. Therefore post-translational proteolytic processing of polyproteins into mature peptides (MPs) has been performed in silico, with a new computational method, for over 200 species in 5 pathogenic virus families (Caliciviridae, Coronaviridae, Flaviviridae, Picornaviridae and Togaviridae).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Using pairwise alignment with reference sequences, MPs have been annotated and their sequences made available for search, analysis and download. At publication the method had produced 156 216 sequences, a large portion of the protein sequences now available in https:\/\/www.viprbrc.org. It represents a new and comprehensive mature peptide collection.<\/jats:p>\n <\/jats:sec>\n \n Availability and implementation<\/jats:title>\n The data are available at the Virus Pathogen Resource https:\/\/www.viprbrc.org, and the software at https:\/\/github.com\/VirusBRC\/vipr_mat_peptide.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btz777","type":"journal-article","created":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T19:57:36Z","timestamp":1570737456000},"page":"1627-1628","source":"Crossref","is-referenced-by-count":3,"title":["Mat_peptide: comprehensive annotation of mature peptides from polyproteins in five virus families"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"http:\/\/orcid.org\/0000-0002-1051-5767","authenticated-orcid":false,"given":"Christopher N","family":"Larsen","sequence":"first","affiliation":[{"name":"Vecna Technologies , Inc., Greenbelt, MD 20770"}]},{"given":"Guangyu","family":"Sun","sequence":"additional","affiliation":[{"name":"Vecna Technologies , Inc., Greenbelt, MD 20770"}]},{"given":"Xiaomei","family":"Li","sequence":"additional","affiliation":[{"name":"Northrop Grumman , Rockville, MD 20850, USA"}]},{"given":"Sam","family":"Zaremba","sequence":"additional","affiliation":[{"name":"Northrop Grumman , Rockville, MD 20850, USA"}]},{"given":"Hongtao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Northrop Grumman , Rockville, MD 20850, USA"}]},{"given":"Sherry","family":"He","sequence":"additional","affiliation":[{"name":"Northrop Grumman , Rockville, MD 20850, USA"}]},{"given":"Liwei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Northrop Grumman , Rockville, MD 20850, USA"}]},{"given":"Sanjeev","family":"Kumar","sequence":"additional","affiliation":[{"name":"Northrop Grumman , Rockville, MD 20850, USA"}]},{"given":"Vince","family":"Desborough","sequence":"additional","affiliation":[{"name":"Northrop Grumman , Rockville, MD 20850, USA"}]},{"given":"Edward B","family":"Klem","sequence":"additional","affiliation":[{"name":"Northrop Grumman , Rockville, MD 20850, USA"}]}],"member":"286","published-online":{"date-parts":[[2019,10,14]]},"reference":[{"key":"2023060910374592500_btz777-B1","doi-asserted-by":"crossref","first-page":"D34","DOI":"10.1093\/nar\/gki063","article-title":"GenBank","volume":"33","author":"Benson","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"2023060910374592500_btz777-B2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0140-6736(16)00003-9","article-title":"Zika virus genome from the Americas","volume":"387","author":"Enfissi","year":"2016","journal-title":"Lancet"},{"key":"2023060910374592500_btz777-B3","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1093\/bioinformatics\/bty851","article-title":"VIRULIGN: fast codon-correct alignment and annotation of viral genomes","volume":"35","author":"Libin","year":"2019","journal-title":"Bioinformatics"},{"key":"2023060910374592500_btz777-B4","first-page":"712","article-title":"Flaviviridae: the viruses and their replication","volume-title":"Flaviviridae. Fields Virology","author":"Lindenbach","year":"2013","edition":"6th edn"},{"key":"2023060910374592500_btz777-B5","doi-asserted-by":"crossref","first-page":"D733","DOI":"10.1093\/nar\/gkv1189","article-title":"Reference sequence (RefSeq) database at NCBI","volume":"44","author":"O\u2019Leary","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"2023060910374592500_btz777-B6","doi-asserted-by":"crossref","first-page":"D593","DOI":"10.1093\/nar\/gkr859","article-title":"ViPR: an open bioinformatics database and analysis resource for virology research","volume":"40","author":"Pickett","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"2023060910374592500_btz777-B7","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1101\/gr.361602","article-title":"The Bioperl toolkit: Perl modules for the life sciences","volume":"12","author":"Stajich","year":"2002","journal-title":"Genome Res"},{"key":"2023060910374592500_btz777-B8","doi-asserted-by":"crossref","first-page":"e0170462","DOI":"10.1371\/journal.pone.0170462","article-title":"Comprehensive annotation of mature peptides and genotypes for Zika virus","volume":"12","author":"Sun","year":"2017","journal-title":"PLoS One"},{"key":"2023060910374592500_btz777-B9","doi-asserted-by":"crossref","first-page":"e1006528","DOI":"10.1371\/journal.ppat.1006528","article-title":"Zika genomics urgently need standardized and curated reference sequences","volume":"13","author":"Theys","year":"2017","journal-title":"PLoS Pathogens"},{"key":"2023060910374592500_btz777-B10","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1093\/nar\/22.22.4673","article-title":"CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice","volume":"22","author":"Thompson","year":"1994","journal-title":"Nucleic Acids Res"},{"key":"2023060910374592500_btz777-B11","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.coviro.2013.03.009","article-title":"Viral precursor polyproteins: keys of regulation from replication to maturation","volume":"3","author":"Yost","year":"2013","journal-title":"Curr. 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