乐胖代购免代理版

{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:38:41Z","timestamp":1740184721774,"version":"3.37.3"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100004917","name":"Cancer Prevention Research Institute of Texas","doi-asserted-by":"publisher","award":["RP170170","RP180410"],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM127390"],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Welch Foundation Grants","award":["I-1532","I-1505"]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,2,1]]},"abstract":"Abstract<\/jats:title>Motivation<\/jats:title>The consensus pattern of Nuclear Export Signal (NES) is a short sequence motif that is commonly identified in protein sequences, whether the motif acts as an NES (true positive) or not (false positive). Finding more plausible NES functioning regions among the vast array of consensus-matching segments would provide an interesting resource for further experimental validation. Better defined NES should also allow meaningful mapping of cancer-related mutation positions, leading to plausible explanations for the relationship between nuclear export and disease.<\/jats:p><\/jats:sec>Results<\/jats:title>Possible NES candidate regions are extracted from the cancer-related human reference proteome. Extracted NES are scored for reliability by combining sequence-based and structure-based approaches. The confidently identified NES candidate motifs were checked for overlap with cancer-related mutation positions annotated in the COSMIC database. Among the \u223c700 cancer-related sequences in the COSMIC Cancer Gene Census, 178 sequences are predicted to have possible NES motifs containing cancer-related mutations at their key positions. These lists are organized into our database (pCRM1exportome), and other protein sequences in the human reference proteome can also be retrieved by their UniProt IDs.<\/jats:p><\/jats:sec>Availability and implementation<\/jats:title>The database is freely available at http:\/\/prodata.swmed.edu\/pCRM1exportome.<\/jats:p><\/jats:sec>Supplementary information<\/jats:title>Supplementary data are available at Bioinformatics online.<\/jats:p><\/jats:sec>","DOI":"10.1093\/bioinformatics\/btz657","type":"journal-article","created":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T19:16:59Z","timestamp":1566328619000},"page":"961-963","source":"Crossref","is-referenced-by-count":7,"title":["pCRM1exportome: database of predicted CRM1-dependent Nuclear Export Signal (NES) motifs in cancer-related genes"],"prefix":"10.1093","volume":"36","author":[{"given":"Yoonji","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Biophysics , TX 75390, USA"}]},{"given":"Jordan M","family":"Baumhardt","sequence":"additional","affiliation":[{"name":"Department of Pharmacology , TX 75390, USA"}]},{"given":"Jimin","family":"Pei","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, University of Texas Southwestern Medical Center , Dallas, TX 75390, USA"}]},{"given":"Yuh Min","family":"Chook","sequence":"additional","affiliation":[{"name":"Department of Pharmacology , TX 75390, USA"}]},{"given":"Nick V","family":"Grishin","sequence":"additional","affiliation":[{"name":"Department of Biophysics , TX 75390, USA"},{"name":"Howard Hughes Medical Institute, University of Texas Southwestern Medical Center , Dallas, TX 75390, USA"}]}],"member":"286","published-online":{"date-parts":[[2019,8,22]]},"reference":[{"key":"2023013110085638900_btz657-B1","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"2023013110085638900_btz657-B2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/gcc.20832","article-title":"A CRM1-dependent nuclear export pathway is involved in the regulation of MutLalpha subcellular localization","volume":"50","author":"Brieger","year":"2011","journal-title":"Genes Chromosomes Cancer"},{"key":"2023013110085638900_btz657-B3","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1038\/onc.2008.21","article-title":"The FoxO code","volume":"27","author":"Calnan","year":"2008","journal-title":"Oncogene"},{"key":"2023013110085638900_btz657-B4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/pro.2389","article-title":"Relaxation of backbone bond geometry improves protein energy landscape modeling","volume":"23","author":"Conway","year":"2014","journal-title":"Protein Sci"},{"key":"2023013110085638900_btz657-B5","doi-asserted-by":"crossref","first-page":"D338","DOI":"10.1093\/nar\/gks936","article-title":"ValidNESs: a database of validated leucine-rich nuclear export signals","volume":"41","author":"Fu","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"2023013110085638900_btz657-B6","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1093\/bioinformatics\/btw678","article-title":"Improving protein disorder prediction by deep bidirectional long short-term memory recurrent neural networks","volume":"33","author":"Hanson","year":"2017","journal-title":"Bioinformatics"},{"key":"2023013110085638900_btz657-B7","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1006\/jmbi.1999.3091","article-title":"Protein secondary structure prediction based on position-specific scoring matrices","volume":"292","author":"Jones","year":"1999","journal-title":"J. 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