{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:38:36Z","timestamp":1740184716004,"version":"3.37.3"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"24","license":[{"start":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T00:00:00Z","timestamp":1562630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"R\u00e9gion Occitanie"},{"name":"French Ministry of Research"},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF14CC0001"],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,15]]},"abstract":"Abstract<\/jats:title>Summary<\/jats:title>With the advent of fully automated sample preparation robots for Hydrogen\u2013Deuterium eXchange coupled to Mass Spectrometry (HDX-MS), this method has become paramount for ligand binding or epitope mapping screening, both in academic research and biopharmaceutical industries. However, bridging the gap between commercial HDX-MS software (for raw data interpretation) and molecular viewers (to map experiment results onto a 3D structure for biological interpretation) remains laborious and requires simple but sometimes limiting coding skills. We solved this bottleneck by developing HDX-Viewer, an open-source web-based application that facilitates and quickens HDX-MS data analysis. This user-friendly application automatically incorporates HDX-MS data from a custom template or commercial HDX-MS software in PDB files, and uploads them to an online 3D molecular viewer, thereby facilitating their visualization and biological interpretation.<\/jats:p><\/jats:sec>Availability and implementation<\/jats:title>The HDX-Viewer web application is released under the CeCILL (http:\/\/www.cecill.info) and GNU LGPL licenses and can be found at https:\/\/masstools.ipbs.fr\/hdx-viewer. The source code is available at https:\/\/github.com\/david-bouyssie\/hdx-viewer.<\/jats:p><\/jats:sec>","DOI":"10.1093\/bioinformatics\/btz550","type":"journal-article","created":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T19:10:16Z","timestamp":1562613016000},"page":"5331-5333","source":"Crossref","is-referenced-by-count":25,"title":["HDX-Viewer: interactive 3D visualization of hydrogen\u2013deuterium exchange data"],"prefix":"10.1093","volume":"35","author":[{"given":"David","family":"Bouyssi\u00e9","sequence":"first","affiliation":[{"name":"Institut de Pharmacologie et de Biologie Structurale, Universit\u00e9 de Toulouse, CNRS , UPS, Toulouse, France"}]},{"given":"Jean","family":"Lesne","sequence":"additional","affiliation":[{"name":"Institut de Pharmacologie et de Biologie Structurale, Universit\u00e9 de Toulouse, CNRS , UPS, Toulouse, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2879-9224","authenticated-orcid":false,"given":"Marie","family":"Locard-Paulet","sequence":"additional","affiliation":[{"name":"Institut de Pharmacologie et de Biologie Structurale, Universit\u00e9 de Toulouse, CNRS , UPS, Toulouse, France"}]},{"given":"Renaud","family":"Albigot","sequence":"additional","affiliation":[{"name":"Institut de Pharmacologie et de Biologie Structurale, Universit\u00e9 de Toulouse, CNRS , UPS, Toulouse, France"}]},{"given":"Odile","family":"Burlet-Schiltz","sequence":"additional","affiliation":[{"name":"Institut de Pharmacologie et de Biologie Structurale, Universit\u00e9 de Toulouse, CNRS , UPS, Toulouse, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7321-7436","authenticated-orcid":false,"given":"Julien","family":"Marcoux","sequence":"additional","affiliation":[{"name":"Institut de Pharmacologie et de Biologie Structurale, Universit\u00e9 de Toulouse, CNRS , UPS, Toulouse, France"}]}],"member":"286","published-online":{"date-parts":[[2019,7,9]]},"reference":[{"key":"2023013108404894500_btz550-B1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/jms.3554","article-title":"Cutting-edge mass spectrometry characterization of originator, biosimilar and biobetter antibodies","volume":"50","author":"Beck","year":"2015","journal-title":"J. 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