{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T10:10:36Z","timestamp":1745057436835,"version":"3.37.3"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"21","license":[{"start":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T00:00:00Z","timestamp":1499299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54 GM114833"],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U41 HG003751"],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012116","name":"European Bioinformatics Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012116","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54 GM114833"],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,11,1]]},"abstract":"Abstract<\/jats:title>\n \n Motivation<\/jats:title>\n Reactome is a free, open-source, open-data, curated and peer-reviewed knowledge base of biomolecular pathways. Pathways are arranged in a hierarchical structure that largely corresponds to the GO biological process hierarchy, allowing the user to navigate from high level concepts like immune system to detailed pathway diagrams showing biomolecular events like membrane transport or phosphorylation. Here, we present new developments in the Reactome visualization system that facilitate navigation through the pathway hierarchy and enable efficient reuse of Reactome visualizations for users\u2019 own research presentations and publications.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n For the higher levels of the hierarchy, Reactome now provides scalable, interactive textbook-style diagrams in SVG format, which are also freely downloadable and editable. Repeated diagram elements like \u2018mitochondrion\u2019 or \u2018receptor\u2019 are available as a library of graphic elements. Detailed lower-level diagrams are now downloadable in editable PPTX format as sets of interconnected objects.<\/jats:p>\n <\/jats:sec>\n \n Availability and implementation<\/jats:title>\n http:\/\/reactome.org<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btx441","type":"journal-article","created":{"date-parts":[[2017,7,5]],"date-time":"2017-07-05T11:33:28Z","timestamp":1499254408000},"page":"3461-3467","source":"Crossref","is-referenced-by-count":144,"title":["Reactome enhanced pathway visualization"],"prefix":"10.1093","volume":"33","author":[{"given":"Konstantinos","family":"Sidiropoulos","sequence":"first","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, UK"}]},{"given":"Guilherme","family":"Viteri","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, UK"}]},{"given":"Cristoffer","family":"Sevilla","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, UK"}]},{"given":"Steve","family":"Jupe","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, UK"}]},{"given":"Marissa","family":"Webber","sequence":"additional","affiliation":[{"name":"Ontario Institute for Cancer Research, Toronto, ON, Canada"}]},{"given":"Marija","family":"Orlic-Milacic","sequence":"additional","affiliation":[{"name":"Ontario Institute for Cancer Research, Toronto, ON, Canada"}]},{"given":"Bijay","family":"Jassal","sequence":"additional","affiliation":[{"name":"Ontario Institute for Cancer Research, Toronto, ON, Canada"}]},{"given":"Bruce","family":"May","sequence":"additional","affiliation":[{"name":"Ontario Institute for Cancer Research, Toronto, ON, Canada"}]},{"given":"Veronica","family":"Shamovsky","sequence":"additional","affiliation":[{"name":"NYU Langone Medical Center, New York, NY, USA"}]},{"given":"Corina","family":"Duenas","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, UK"}]},{"given":"Karen","family":"Rothfels","sequence":"additional","affiliation":[{"name":"Ontario Institute for Cancer Research, Toronto, ON, Canada"}]},{"given":"Lisa","family":"Matthews","sequence":"additional","affiliation":[{"name":"NYU Langone Medical Center, New York, NY, USA"}]},{"given":"Heeyeon","family":"Song","sequence":"additional","affiliation":[{"name":"Ontario Institute for Cancer Research, Toronto, ON, Canada"}]},{"given":"Lincoln","family":"Stein","sequence":"additional","affiliation":[{"name":"Ontario Institute for Cancer Research, Toronto, ON, Canada"},{"name":"Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada"}]},{"given":"Robin","family":"Haw","sequence":"additional","affiliation":[{"name":"Ontario Institute for Cancer Research, Toronto, ON, Canada"}]},{"given":"Peter","family":"D\u2019Eustachio","sequence":"additional","affiliation":[{"name":"NYU Langone Medical Center, New York, NY, USA"}]},{"given":"Peipei","family":"Ping","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medicine and Bioinformatics, NIH BD2K Center of Excellence, University of California, Los Angeles, CA, USA"}]},{"given":"Henning","family":"Hermjakob","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, UK"},{"name":"State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, National Center for Protein Sciences - Beijing, Beijing, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3288-8599","authenticated-orcid":false,"given":"Antonio","family":"Fabregat","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, UK"},{"name":"OpenTargets, Wellcome Genome Campus, Hinxton, UK"}]}],"member":"286","published-online":{"date-parts":[[2017,7,6]]},"reference":[{"key":"2023051506353165000_btx441-B1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. 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