{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T07:34:55Z","timestamp":1742801695058},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,7,15]]},"abstract":"Abstract<\/jats:title>\n Summary: Constraint network analysis (CNA) is a graph theory-based rigidity analysis approach for linking a biomolecule\u2019s structure, flexibility, (thermo)stability and function. Results from CNA are highly information-rich and require intuitive, synchronized and interactive visualization for a comprehensive analysis. We developed VisualCNA, an easy-to-use PyMOL plug-in that allows setup of CNA runs and analysis of CNA results linking plots with molecular graphics representations. From a practical viewpoint, the most striking feature of VisualCNA is that it facilitates interactive protein engineering aimed at improving thermostability.<\/jats:p>\n Availability and Implementation: VisualCNA and its dependencies (CNA and FIRST software) are available free of charge under GPL and academic licenses, respectively. VisualCNA and CNA are available at http:\/\/cpclab.uni-duesseldorf.de\/software; FIRST is available at http:\/\/flexweb.asu.edu.<\/jats:p>\n Contact: \u00a0gohlke@uni-duesseldorf.de<\/jats:p>","DOI":"10.1093\/bioinformatics\/btv139","type":"journal-article","created":{"date-parts":[[2015,3,14]],"date-time":"2015-03-14T00:26:33Z","timestamp":1426292793000},"page":"2394-2396","source":"Crossref","is-referenced-by-count":14,"title":["VisualCNA: a GUI for interactive constraint network analysis and protein engineering for improving thermostability"],"prefix":"10.1093","volume":"31","author":[{"given":"Prakash Chandra","family":"Rathi","sequence":"first","affiliation":[{"name":"Institute for Pharmaceutical and Medicinal Chemistry, Department of Mathematics and Natural Sciences, Heinrich-Heine-University, Universit\u00e4tsstr. 1, D\u00fcsseldorf, Germany"}]},{"given":"Daniel","family":"Mulnaes","sequence":"additional","affiliation":[{"name":"Institute for Pharmaceutical and Medicinal Chemistry, Department of Mathematics and Natural Sciences, Heinrich-Heine-University, Universit\u00e4tsstr. 1, D\u00fcsseldorf, Germany"}]},{"given":"Holger","family":"Gohlke","sequence":"additional","affiliation":[{"name":"Institute for Pharmaceutical and Medicinal Chemistry, Department of Mathematics and Natural Sciences, Heinrich-Heine-University, Universit\u00e4tsstr. 1, D\u00fcsseldorf, Germany"}]}],"member":"286","published-online":{"date-parts":[[2015,3,12]]},"reference":[{"key":"2023020202160432400_btv139-B1","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1103\/PhysRevLett.75.4051","article-title":"Generic rigidity percolation: the pebble game","volume":"75","author":"Jacobs","year":"1995","journal-title":"Phys. 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