{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:40:31Z","timestamp":1675298431259},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,6,15]]},"abstract":"Abstract<\/jats:title>\n Motivation: Most biological processes remain only partially characterized with many components still to be identified. Given that a whole genome can usually not be tested in a functional assay, identifying the genes most likely to be of interest is of critical importance to avoid wasting resources.<\/jats:p>\n Results: Given a set of known functionally related genes and using a state-of-the-art approach to data integration and mining, our Functional Lists (FUN-L) method provides a ranked list of candidate genes for testing. Validation of predictions from FUN-L with independent RNAi screens confirms that FUN-L-produced lists are enriched in genes with the expected phenotypes. In this article, we describe a website front end to FUN-L.<\/jats:p>\n Availability and implementation: The website is freely available to use at http:\/\/funl.org<\/jats:p>\n Contact: \u00a0ucbcjle@live.ucl.ac.uk<\/jats:p>","DOI":"10.1093\/bioinformatics\/btv073","type":"journal-article","created":{"date-parts":[[2015,2,10]],"date-time":"2015-02-10T01:14:08Z","timestamp":1423530848000},"page":"2052-2053","source":"Crossref","is-referenced-by-count":8,"title":["FUN-L: gene prioritization for RNAi screens"],"prefix":"10.1093","volume":"31","author":[{"given":"Jonathan G.","family":"Lees","sequence":"first","affiliation":[{"name":"1 Research Department of Structural & Molecular Biology, University College London, London, UK, 2Cell Biology\/Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany, 3Inflamex-Laboratoire Analyse G\u00e9om\u00e9trie et Applications, Universit\u00e9 Paris Nord-Sorbonne, France, 4Structural Bioinformatics Group, Spanish National Cancer Research Centre (CNIO) and Spanish National Bioinformatics Institute (INB), Madrid, Spain, 5Institute of Molecular and Cell Biology, and 6Institute of Computer Science, University of Tartu, Tartu, Estonia and 7Department of Molecular Biology and Biochemistry-CIBER de Enfermedades Raras, University of Malaga, Malaga, Spain"}]},{"given":"Jean-Karim","family":"H\u00e9rich\u00e9","sequence":"additional","affiliation":[{"name":"1 Research Department of Structural & Molecular Biology, University College London, London, UK, 2Cell Biology\/Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany, 3Inflamex-Laboratoire Analyse G\u00e9om\u00e9trie et Applications, Universit\u00e9 Paris Nord-Sorbonne, France, 4Structural Bioinformatics Group, Spanish National Cancer Research Centre (CNIO) and Spanish National Bioinformatics Institute (INB), Madrid, Spain, 5Institute of Molecular and Cell Biology, and 6Institute of Computer Science, University of Tartu, Tartu, Estonia and 7Department of Molecular Biology and Biochemistry-CIBER de Enfermedades Raras, University of Malaga, Malaga, Spain"}]},{"given":"Ian","family":"Morilla","sequence":"additional","affiliation":[{"name":"1 Research Department of Structural & Molecular Biology, University College London, London, UK, 2Cell Biology\/Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany, 3Inflamex-Laboratoire Analyse G\u00e9om\u00e9trie et Applications, Universit\u00e9 Paris Nord-Sorbonne, France, 4Structural Bioinformatics Group, Spanish National Cancer Research Centre (CNIO) and Spanish National Bioinformatics Institute (INB), Madrid, Spain, 5Institute of Molecular and Cell Biology, and 6Institute of Computer Science, University of Tartu, Tartu, Estonia and 7Department of Molecular Biology and Biochemistry-CIBER de Enfermedades Raras, University of Malaga, Malaga, Spain"}]},{"given":"Jos\u00e9 M.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"1 Research Department of Structural & Molecular Biology, University College London, London, UK, 2Cell Biology\/Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany, 3Inflamex-Laboratoire Analyse G\u00e9om\u00e9trie et Applications, Universit\u00e9 Paris Nord-Sorbonne, France, 4Structural Bioinformatics Group, Spanish National Cancer Research Centre (CNIO) and Spanish National Bioinformatics Institute (INB), Madrid, Spain, 5Institute of Molecular and Cell Biology, and 6Institute of Computer Science, University of Tartu, Tartu, Estonia and 7Department of Molecular Biology and Biochemistry-CIBER de Enfermedades Raras, University of Malaga, Malaga, Spain"}]},{"given":"Priit","family":"Adler","sequence":"additional","affiliation":[{"name":"1 Research Department of Structural & Molecular Biology, University College London, London, UK, 2Cell Biology\/Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany, 3Inflamex-Laboratoire Analyse G\u00e9om\u00e9trie et Applications, Universit\u00e9 Paris Nord-Sorbonne, France, 4Structural Bioinformatics Group, Spanish National Cancer Research Centre (CNIO) and Spanish National Bioinformatics Institute (INB), Madrid, Spain, 5Institute of Molecular and Cell Biology, and 6Institute of Computer Science, University of Tartu, Tartu, Estonia and 7Department of Molecular Biology and Biochemistry-CIBER de Enfermedades Raras, University of Malaga, Malaga, Spain"}]},{"given":"Martin","family":"Krallinger","sequence":"additional","affiliation":[{"name":"1 Research Department of Structural & Molecular Biology, University College London, London, UK, 2Cell Biology\/Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany, 3Inflamex-Laboratoire Analyse G\u00e9om\u00e9trie et Applications, Universit\u00e9 Paris Nord-Sorbonne, France, 4Structural Bioinformatics Group, Spanish National Cancer Research Centre (CNIO) and Spanish National Bioinformatics Institute (INB), Madrid, Spain, 5Institute of Molecular and Cell Biology, and 6Institute of Computer Science, University of Tartu, Tartu, Estonia and 7Department of Molecular Biology and Biochemistry-CIBER de Enfermedades Raras, University of Malaga, Malaga, Spain"}]},{"given":"Jaak","family":"Vilo","sequence":"additional","affiliation":[{"name":"1 Research Department of Structural & Molecular Biology, University College London, London, UK, 2Cell Biology\/Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany, 3Inflamex-Laboratoire Analyse G\u00e9om\u00e9trie et Applications, Universit\u00e9 Paris Nord-Sorbonne, France, 4Structural Bioinformatics Group, Spanish National Cancer Research Centre (CNIO) and Spanish National Bioinformatics Institute (INB), Madrid, Spain, 5Institute of Molecular and Cell Biology, and 6Institute of Computer Science, University of Tartu, Tartu, Estonia and 7Department of Molecular Biology and Biochemistry-CIBER de Enfermedades Raras, University of Malaga, Malaga, Spain"}]},{"given":"Alfonso","family":"Valencia","sequence":"additional","affiliation":[{"name":"1 Research Department of Structural & Molecular Biology, University College London, London, UK, 2Cell Biology\/Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany, 3Inflamex-Laboratoire Analyse G\u00e9om\u00e9trie et Applications, Universit\u00e9 Paris Nord-Sorbonne, France, 4Structural Bioinformatics Group, Spanish National Cancer Research Centre (CNIO) and Spanish National Bioinformatics Institute (INB), Madrid, Spain, 5Institute of Molecular and Cell Biology, and 6Institute of Computer Science, University of Tartu, Tartu, Estonia and 7Department of Molecular Biology and Biochemistry-CIBER de Enfermedades Raras, University of Malaga, Malaga, Spain"}]},{"given":"Jan","family":"Ellenberg","sequence":"additional","affiliation":[{"name":"1 Research Department of Structural & Molecular Biology, University College London, London, UK, 2Cell Biology\/Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany, 3Inflamex-Laboratoire Analyse G\u00e9om\u00e9trie et Applications, Universit\u00e9 Paris Nord-Sorbonne, France, 4Structural Bioinformatics Group, Spanish National Cancer Research Centre (CNIO) and Spanish National Bioinformatics Institute (INB), Madrid, Spain, 5Institute of Molecular and Cell Biology, and 6Institute of Computer Science, University of Tartu, Tartu, Estonia and 7Department of Molecular Biology and Biochemistry-CIBER de Enfermedades Raras, University of Malaga, Malaga, Spain"}]},{"given":"Juan A.","family":"Ranea","sequence":"additional","affiliation":[{"name":"1 Research Department of Structural & Molecular Biology, University College London, London, UK, 2Cell Biology\/Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany, 3Inflamex-Laboratoire Analyse G\u00e9om\u00e9trie et Applications, Universit\u00e9 Paris Nord-Sorbonne, France, 4Structural Bioinformatics Group, Spanish National Cancer Research Centre (CNIO) and Spanish National Bioinformatics Institute (INB), Madrid, Spain, 5Institute of Molecular and Cell Biology, and 6Institute of Computer Science, University of Tartu, Tartu, Estonia and 7Department of Molecular Biology and Biochemistry-CIBER de Enfermedades Raras, University of Malaga, Malaga, Spain"}]},{"given":"Christine","family":"Orengo","sequence":"additional","affiliation":[{"name":"1 Research Department of Structural & Molecular Biology, University College London, London, UK, 2Cell Biology\/Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany, 3Inflamex-Laboratoire Analyse G\u00e9om\u00e9trie et Applications, Universit\u00e9 Paris Nord-Sorbonne, France, 4Structural Bioinformatics Group, Spanish National Cancer Research Centre (CNIO) and Spanish National Bioinformatics Institute (INB), Madrid, Spain, 5Institute of Molecular and Cell Biology, and 6Institute of Computer Science, University of Tartu, Tartu, Estonia and 7Department of Molecular Biology and Biochemistry-CIBER de Enfermedades Raras, University of Malaga, Malaga, Spain"}]}],"member":"286","published-online":{"date-parts":[[2015,2,8]]},"reference":[{"key":"2023020115401213700_btv073-B1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. 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