{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T06:24:53Z","timestamp":1746339893115},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"16","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":1558,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,8,15]]},"abstract":"Abstract<\/jats:title>\n Summary: We introduce GO-Elite, a flexible and powerful pathway analysis tool for a wide array of species, identifiers (IDs), pathways, ontologies and gene sets. In addition to the Gene Ontology (GO), GO-Elite allows the user to perform over-representation analysis on any structured ontology annotations, pathway database or biological IDs (e.g. gene, protein or metabolite). GO-Elite exploits the structured nature of biological ontologies to report a minimal set of non-overlapping terms. The results can be visualized on WikiPathways or as networks. Built-in support is provided for over 60 species and 50 ID systems, covering gene, disease and phenotype ontologies, multiple pathway databases, biomarkers, and transcription factor and microRNA targets. GO-Elite is available as a web interface, GenMAPP-CS plugin and as a cross-platform application.<\/jats:p>\n Availability: \u00a0http:\/\/www.genmapp.org\/go_elite<\/jats:p>\n Contact: \u00a0nsalomonis@gladstone.ucsf.edu<\/jats:p>\n Supplementary Information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/bts366","type":"journal-article","created":{"date-parts":[[2012,6,29]],"date-time":"2012-06-29T00:52:19Z","timestamp":1340931139000},"page":"2209-2210","source":"Crossref","is-referenced-by-count":244,"title":["GO-Elite: a flexible solution for pathway and ontology over-representation"],"prefix":"10.1093","volume":"28","author":[{"given":"Alexander C.","family":"Zambon","sequence":"first","affiliation":[{"name":"1 Departments of Pharmacology and Medicine, University of California at San Diego, La Jolla, CA 92093, USA, 2Department of Bioinformatics\u2014BiGCaT, Maastricht University, Maastricht, The Netherlands, 3Gladstone Institute of Cardiovascular Disease and 4Departments of Medicine and Molecular and Cellular Pharmacology, University of California, San Francisco, CA 94158, USA"}]},{"given":"Stan","family":"Gaj","sequence":"additional","affiliation":[{"name":"1 Departments of Pharmacology and Medicine, University of California at San Diego, La Jolla, CA 92093, USA, 2Department of Bioinformatics\u2014BiGCaT, Maastricht University, Maastricht, The Netherlands, 3Gladstone Institute of Cardiovascular Disease and 4Departments of Medicine and Molecular and Cellular Pharmacology, University of California, San Francisco, CA 94158, USA"}]},{"given":"Isaac","family":"Ho","sequence":"additional","affiliation":[{"name":"1 Departments of Pharmacology and Medicine, University of California at San Diego, La Jolla, CA 92093, USA, 2Department of Bioinformatics\u2014BiGCaT, Maastricht University, Maastricht, The Netherlands, 3Gladstone Institute of Cardiovascular Disease and 4Departments of Medicine and Molecular and Cellular Pharmacology, University of California, San Francisco, CA 94158, USA"}]},{"given":"Kristina","family":"Hanspers","sequence":"additional","affiliation":[{"name":"1 Departments of Pharmacology and Medicine, University of California at San Diego, La Jolla, CA 92093, USA, 2Department of Bioinformatics\u2014BiGCaT, Maastricht University, Maastricht, The Netherlands, 3Gladstone Institute of Cardiovascular Disease and 4Departments of Medicine and Molecular and Cellular Pharmacology, University of California, San Francisco, CA 94158, USA"}]},{"given":"Karen","family":"Vranizan","sequence":"additional","affiliation":[{"name":"1 Departments of Pharmacology and Medicine, University of California at San Diego, La Jolla, CA 92093, USA, 2Department of Bioinformatics\u2014BiGCaT, Maastricht University, Maastricht, The Netherlands, 3Gladstone Institute of Cardiovascular Disease and 4Departments of Medicine and Molecular and Cellular Pharmacology, University of California, San Francisco, CA 94158, USA"}]},{"given":"Chris T.","family":"Evelo","sequence":"additional","affiliation":[{"name":"1 Departments of Pharmacology and Medicine, University of California at San Diego, La Jolla, CA 92093, USA, 2Department of Bioinformatics\u2014BiGCaT, Maastricht University, Maastricht, The Netherlands, 3Gladstone Institute of Cardiovascular Disease and 4Departments of Medicine and Molecular and Cellular Pharmacology, University of California, San Francisco, CA 94158, USA"}]},{"given":"Bruce R.","family":"Conklin","sequence":"additional","affiliation":[{"name":"1 Departments of Pharmacology and Medicine, University of California at San Diego, La Jolla, CA 92093, USA, 2Department of Bioinformatics\u2014BiGCaT, Maastricht University, Maastricht, The Netherlands, 3Gladstone Institute of Cardiovascular Disease and 4Departments of Medicine and Molecular and Cellular Pharmacology, University of California, San Francisco, CA 94158, USA"},{"name":"1 Departments of Pharmacology and Medicine, University of California at San Diego, La Jolla, CA 92093, USA, 2Department of Bioinformatics\u2014BiGCaT, Maastricht University, Maastricht, The Netherlands, 3Gladstone Institute of Cardiovascular Disease and 4Departments of Medicine and Molecular and Cellular Pharmacology, University of California, San Francisco, CA 94158, USA"}]},{"given":"Alexander R.","family":"Pico","sequence":"additional","affiliation":[{"name":"1 Departments of Pharmacology and Medicine, University of California at San Diego, La Jolla, CA 92093, USA, 2Department of Bioinformatics\u2014BiGCaT, Maastricht University, Maastricht, The Netherlands, 3Gladstone Institute of Cardiovascular Disease and 4Departments of Medicine and Molecular and Cellular Pharmacology, University of California, San Francisco, CA 94158, USA"}]},{"given":"Nathan","family":"Salomonis","sequence":"additional","affiliation":[{"name":"1 Departments of Pharmacology and Medicine, University of California at San Diego, La Jolla, CA 92093, USA, 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