{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,4]],"date-time":"2024-08-04T05:58:19Z","timestamp":1722751099589},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,8,1]]},"abstract":"Abstract<\/jats:title>\n Summary: To reveal how the polycomb repressive\u2013deubiquitinase (PR\u2013DUB) complex controls substrate selection specificity, we undertook a detailed computational sequence analysis of its components: additional sex combs like 1 (ASXL1) and BRCA1-associated protein 1 (BAP1) proteins. This led to the discovery of two previously unrecognized domains in ASXL1: a forkhead (winged-helix) DNA-binding domain and a deubiquitinase adaptor domain shared with two regulators of ubiquitin carboxyl-terminal hydrolase 37 (Uch37), namely adhesion regulating molecule 1 (ADRM1) and nuclear factor related to kappaB (NFRKB). Our analysis demonstrates a common ancestry for BAP1 and Uch37 regulators in PR\u2013DUB, INO80 chromatin remodelling and proteosome complexes.<\/jats:p>\n Contact: \u00a0luis.sanchezpulido@dpag.ox.ac.uk<\/jats:p>\n Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/bts319","type":"journal-article","created":{"date-parts":[[2012,5,30]],"date-time":"2012-05-30T02:10:12Z","timestamp":1338343812000},"page":"1953-1956","source":"Crossref","is-referenced-by-count":46,"title":["A common ancestry for BAP1 and Uch37 regulators"],"prefix":"10.1093","volume":"28","author":[{"given":"Luis","family":"Sanchez-Pulido","sequence":"first","affiliation":[{"name":"MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK"}]},{"given":"Lesheng","family":"Kong","sequence":"additional","affiliation":[{"name":"MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK"}]},{"given":"Chris P.","family":"Ponting","sequence":"additional","affiliation":[{"name":"MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK"}]}],"member":"286","published-online":{"date-parts":[[2012,5,29]]},"reference":[{"key":"2023012512450848400_B1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4161\/cc.11.1.18475","article-title":"The HARE-HTH and associated domains: novel modules in the coordination of epigenetic DNA and protein modifications","volume":"11","author":"Aravind","year":"2012","journal-title":"Cell Cycle"},{"key":"2023012512450848400_B2","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1056\/NEJMoa1013343","article-title":"Clinical effect of point mutations in myelodysplastic syndromes","volume":"364","author":"Bejar","year":"2011","journal-title":"N. 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