{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T10:20:25Z","timestamp":1704190825289},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,4,1]]},"abstract":"Abstract<\/jats:title>\n Summary: We developed Breakpointer, a fast algorithm to locate breakpoints of structural variants (SVs) from single-end reads produced by next-generation sequencing. By taking advantage of local non-uniform read distribution and misalignments created by SVs, Breakpointer scans the alignment of single-end reads to identify regions containing potential breakpoints. The detection of such breakpoints can indicate insertions longer than the read length and SVs located in repetitve regions which might be missd by other methods. Thus, Breakpointer complements existing methods to locate SVs from single-end reads.<\/jats:p>\n Availability: \u00a0https:\/\/github.com\/ruping\/Breakpointer<\/jats:p>\n Contact: \u00a0ruping@molgen.mpg.de<\/jats:p>\n Supplementary information: \u00a0Supplementary material is available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/bts064","type":"journal-article","created":{"date-parts":[[2012,2,3]],"date-time":"2012-02-03T01:42:17Z","timestamp":1328233337000},"page":"1024-1025","source":"Crossref","is-referenced-by-count":20,"title":["Breakpointer: using local mapping artifacts to support sequence breakpoint discovery from single-end reads"],"prefix":"10.1093","volume":"28","author":[{"given":"Ruping","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Computational Molecular Biology, Max-Planck-Institute for Molecular Genetics, Ihnestr. 63\u201373, 14195 Berlin, Germany"}]},{"given":"Michael I.","family":"Love","sequence":"additional","affiliation":[{"name":"Department of Computational Molecular Biology, Max-Planck-Institute for Molecular Genetics, Ihnestr. 63\u201373, 14195 Berlin, Germany"}]},{"given":"Tomasz","family":"Zemojtel","sequence":"additional","affiliation":[{"name":"Department of Computational Molecular Biology, Max-Planck-Institute for Molecular Genetics, Ihnestr. 63\u201373, 14195 Berlin, Germany"}]},{"given":"Anne-Katrin","family":"Emde","sequence":"additional","affiliation":[{"name":"Department of Computational Molecular Biology, Max-Planck-Institute for Molecular Genetics, Ihnestr. 63\u201373, 14195 Berlin, Germany"}]},{"given":"Ho-Ryun","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Computational Molecular Biology, Max-Planck-Institute for Molecular Genetics, Ihnestr. 63\u201373, 14195 Berlin, Germany"}]},{"given":"Martin","family":"Vingron","sequence":"additional","affiliation":[{"name":"Department of Computational Molecular Biology, Max-Planck-Institute for Molecular Genetics, Ihnestr. 63\u201373, 14195 Berlin, Germany"}]},{"given":"Stefan A.","family":"Haas","sequence":"additional","affiliation":[{"name":"Department of Computational Molecular Biology, Max-Planck-Institute for Molecular Genetics, Ihnestr. 63\u201373, 14195 Berlin, Germany"}]}],"member":"286","published-online":{"date-parts":[[2012,2,1]]},"reference":[{"key":"2023012512220823300_B1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nrg2958","article-title":"Genome structural variation discovery and genotyping","volume":"12","author":"Alkan","year":"2011","journal-title":"Nat. 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