{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T05:20:02Z","timestamp":1674710402107},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,2,1]]},"abstract":"Abstract<\/jats:title>\n Motivation: Information concerning the gene expression pattern in four dimensions (species, genes, anatomy and developmental stage) is crucial for unraveling the roles of genes through time. There are a variety of anatomical gene expression databases, but extracting information from them can be hampered by their diversity and heterogeneity.<\/jats:p>\n Results: aGEM 3.1 (anatomic Gene Expression Mapping) addresses the issues of diversity and heterogeneity of anatomical gene expression databases by integrating six mouse gene expression resources (EMAGE, GXD, GENSAT, Allen Brain Atlas data base, EUREXPRESS and BioGPS) and three human gene expression databases (HUDSEN, Human Protein Atlas and BioGPS). Furthermore, aGEM 3.1 provides new cross analysis tools to bridge these resources.<\/jats:p>\n Availability and implementation: aGEM 3.1 can be queried using gene and anatomical structure. Output information is presented in a friendly format, allowing the user to display expression maps and correlation matrices for a gene or structure during development. An in-depth study of a specific developmental stage is also possible using heatmaps that relate gene expression with anatomical components. http:\/\/agem.cnb.csic.es<\/jats:p>\n Contact: \u00a0natalia@cnb.csic.es<\/jats:p>\n Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btr639","type":"journal-article","created":{"date-parts":[[2011,11,22]],"date-time":"2011-11-22T04:39:50Z","timestamp":1321936790000},"page":"397-402","source":"Crossref","is-referenced-by-count":1,"title":["Integrating human and murine anatomical gene expression data for improved comparisons"],"prefix":"10.1093","volume":"28","author":[{"given":"Natalia","family":"Jim\u00e9nez-Lozano","sequence":"first","affiliation":[{"name":"1 GN7 of the National Institute for Bioinformatics (INB), 2Biocomputing Unit of the National Centre for Biotechnology (CNB-CSIC), Darwin, 3, 28049 Madrid, Spain and 3Computational Biology Group of the Leeds Institute of Molecular Medicine, Section of Experimental Therapeutics, Welcome Trust Brenner Building, St James's University Hospital, Leeds LS9 7TF, UK"},{"name":"1 GN7 of the National Institute for Bioinformatics (INB), 2Biocomputing Unit of the National Centre for Biotechnology (CNB-CSIC), Darwin, 3, 28049 Madrid, Spain and 3Computational Biology Group of the Leeds Institute of Molecular Medicine, Section of Experimental Therapeutics, Welcome Trust Brenner Building, St James's University Hospital, Leeds LS9 7TF, UK"}]},{"given":"Joan","family":"Segura","sequence":"additional","affiliation":[{"name":"1 GN7 of the National Institute for Bioinformatics (INB), 2Biocomputing Unit of the National Centre for Biotechnology (CNB-CSIC), Darwin, 3, 28049 Madrid, Spain and 3Computational Biology Group of the Leeds Institute of Molecular Medicine, Section of Experimental Therapeutics, Welcome Trust Brenner Building, St James's University Hospital, Leeds LS9 7TF, UK"}]},{"given":"Jos\u00e9 Ram\u00f3n","family":"Mac\u00edas","sequence":"additional","affiliation":[{"name":"1 GN7 of the National Institute for Bioinformatics (INB), 2Biocomputing Unit of the National Centre for Biotechnology (CNB-CSIC), Darwin, 3, 28049 Madrid, Spain and 3Computational Biology Group of the Leeds Institute of Molecular Medicine, Section of Experimental Therapeutics, Welcome Trust Brenner Building, St James's University Hospital, Leeds LS9 7TF, UK"}]},{"given":"Juanjo","family":"Vega","sequence":"additional","affiliation":[{"name":"1 GN7 of the National Institute for Bioinformatics (INB), 2Biocomputing Unit of the National Centre for Biotechnology (CNB-CSIC), Darwin, 3, 28049 Madrid, Spain and 3Computational Biology Group of the Leeds Institute of Molecular Medicine, Section of Experimental Therapeutics, Welcome Trust Brenner Building, St James's University Hospital, Leeds LS9 7TF, UK"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Carazo","sequence":"additional","affiliation":[{"name":"1 GN7 of the National Institute for Bioinformatics (INB), 2Biocomputing Unit of the National Centre for Biotechnology (CNB-CSIC), Darwin, 3, 28049 Madrid, Spain and 3Computational Biology Group of the Leeds Institute of Molecular Medicine, Section of Experimental Therapeutics, Welcome Trust Brenner Building, St James's University Hospital, Leeds LS9 7TF, UK"},{"name":"1 GN7 of the National Institute for Bioinformatics (INB), 2Biocomputing Unit of the National Centre for Biotechnology (CNB-CSIC), Darwin, 3, 28049 Madrid, Spain and 3Computational Biology Group of the Leeds Institute of Molecular Medicine, Section of Experimental Therapeutics, Welcome Trust Brenner Building, St James's University Hospital, Leeds LS9 7TF, UK"}]}],"member":"286","published-online":{"date-parts":[[2011,11,20]]},"reference":[{"key":"2023012512165055500_B1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/978-1-84628-885-2_12","article-title":"The Edinburgh Mouse Atlas","volume-title":"Anatomy Ontologies 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