{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T08:52:47Z","timestamp":1725439967775},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"18","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,12,12]]},"abstract":"Abstract<\/jats:title>\n Summary: ViTO is a graphical application, including an editor, of multiple sequence alignment and a three-dimensional (3D) structure viewer. It is possible to manipulate alignments containing hundreds of sequences and to display a dozen structures. ViTO can handle so-called \u2018multiparts\u2019 alignments to allow the visualization of complex structures (multi-chain proteins and\/or small molecules and DNA) and the editing of the corresponding alignment. The 3D viewer and the alignment editor are connected together allowing rapid refinement of sequence\u2013structure alignment by taking advantage of the immediate visualization of resulting insertions\/deletions and strict conservations in their structural context. More generally, it allows the mapping of informations about the sequence conservation extracted from the alignment onto the 3D structures in a dynamic way. ViTO is also connected to two comparative modelling programs, SCWRL and MODELLER.<\/jats:p>\n These features make ViTO a powerful tool to characterize protein families and to optimize the alignments for comparative modelling.<\/jats:p>\n Availability: \u00a0http:\/\/bioserv.cbs.cnrs.fr\/VITO\/DOC\/<\/jats:p>\n Supplementary information: \u00a0http:\/\/bioserv.cbs.cnrs.fr\/VITO\/DOC\/index.html<\/jats:p>","DOI":"10.1093\/bioinformatics\/bth429","type":"journal-article","created":{"date-parts":[[2004,7,24]],"date-time":"2004-07-24T01:27:46Z","timestamp":1090632466000},"page":"3694-3696","source":"Crossref","is-referenced-by-count":52,"title":["ViTO: tool for refinement of protein sequence\u2013structure alignments"],"prefix":"10.1093","volume":"20","author":[{"given":"Vincent","family":"Catherinot","sequence":"first","affiliation":[{"name":"Centre de Biochimie Structurale, INSERM U414, CNRS UMR5048, Universit\u00e9 Montpellier 1 15, Avenue Charles Flahault 34060 Montpellier Cedex, France"}]},{"given":"Gilles","family":"Labesse","sequence":"additional","affiliation":[{"name":"Centre de Biochimie Structurale, INSERM U414, CNRS UMR5048, Universit\u00e9 Montpellier 1 15, Avenue Charles Flahault 34060 Montpellier Cedex, France"}]}],"member":"286","published-online":{"date-parts":[[2004,7,22]]},"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/20\/18\/3694\/48906611\/bioinformatics_20_18_3694.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/20\/18\/3694\/48906611\/bioinformatics_20_18_3694.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T17:08:00Z","timestamp":1674666480000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/20\/18\/3694\/202369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7,22]]},"references-count":0,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2004,12,12]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/bth429","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2004,12,12]]},"published":{"date-parts":[[2004,7,22]]}}}