乐胖代购免代理版

{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T00:34:47Z","timestamp":1725669287709},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"German Federal Ministry of Education and Research"},{"name":"FitMultiCell","award":["031L0159B","031L0159C"]},{"name":"EMUNE","award":["031L0293C","031L0293X"]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Germany\u2019s Excellence Strategy","award":["390873048\u2014EXC 2151","390685813\u2014EXC 2047"]},{"DOI":"10.13039\/501100012284","name":"Chica and Heinz Schaller Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012284","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"Abstract<\/jats:title>\n \n Motivation<\/jats:title>\n Biological tissues are dynamic and highly organized. Multi-scale models are helpful tools to analyse and understand the processes determining tissue dynamics. These models usually depend on parameters that need to be inferred from experimental data to achieve a quantitative understanding, to predict the response to perturbations, and to evaluate competing hypotheses. However, even advanced inference approaches such as approximate Bayesian computation (ABC) are difficult to apply due to the computational complexity of the simulation of multi-scale models. Thus, there is a need for a scalable pipeline for modeling, simulating, and parameterizing multi-scale models of multi-cellular processes.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Here, we present FitMultiCell, a computationally efficient and user-friendly open-source pipeline that can handle the full workflow of modeling, simulating, and parameterizing for multi-scale models of multi-cellular processes. The pipeline is modular and integrates the modeling and simulation tool Morpheus and the statistical inference tool pyABC. The easy integration of high-performance infrastructure allows to scale to computationally expensive problems. The introduction of a novel standard for the formulation of parameter inference problems for multi-scale models additionally ensures reproducibility and reusability. By applying the pipeline to multiple biological problems, we demonstrate its broad applicability, which will benefit in particular image-based systems biology.<\/jats:p>\n <\/jats:sec>\n \n Availability and implementation<\/jats:title>\n FitMultiCell is available open-source at https:\/\/gitlab.com\/fitmulticell\/fit.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btad674","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T12:27:21Z","timestamp":1699619241000},"source":"Crossref","is-referenced-by-count":0,"title":["FitMultiCell: simulating and parameterizing computational models of multi-scale and multi-cellular processes"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"http:\/\/orcid.org\/0000-0002-9129-4635","authenticated-orcid":false,"given":"Emad","family":"Alamoudi","sequence":"first","affiliation":[{"name":"Life and Medical Sciences Institute, University of Bonn , Bonn 53113, Germany"}]},{"given":"Yannik","family":"Sch\u00e4lte","sequence":"additional","affiliation":[{"name":"Life and Medical Sciences Institute, University of Bonn , Bonn 53113, Germany"},{"name":"Institute of Computational Biology, Helmholtz Zentrum M\u00fcnchen\u2014German Research Center for Environmental Health , Neuherberg 85764, Germany"},{"name":"Center for Mathematics, Chair of Mathematical Modeling of Biological Systems, Technische Universit\u00e4t M\u00fcnchen , Garching 85748, Germany"}]},{"given":"Robert","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Center of Information Services and High Performance Computing (ZIH), Technische Universit\u00e4t Dresden , Dresden 01062, Germany"}]},{"given":"J\u00f6rn","family":"Starru\u00df","sequence":"additional","affiliation":[{"name":"Center of Information Services and High Performance Computing (ZIH), Technische Universit\u00e4t Dresden , Dresden 01062, 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