{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T21:59:13Z","timestamp":1717711153448},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,3,1]]},"abstract":"Abstract<\/jats:title>\n MOTIVATION: To cope with the increasing amount of sequence data, reliable automatic annotation tools are required. The TrEMBL database contains together with SWISS-PROT nearly all publicly available protein sequences, but in contrast to SWISS-PROT only limited functional annotation. To improve this situation, we had to develop a method of automatic annotation that produces highly reliable functional prediction using the language and the syntax of SWISS-PROT. RESULTS: An algorithm was developed and successfully used for the automatic annotation of a testset of unknown proteins. The predicted information included description, function, catalytic activity, cofactors, pathway, subcellular location, quaternary structure, similarity to other protein, active sites, and keywords. The algorithm showed a low coverage (10%), but a high specificity and reliability. AVAILABILITY: The results can be obtained by anonymous ftp from ftp.ebi.ac.uk\/pub\/databases\/sp_tr_nrdb. The source code is available on request from the authors.<\/jats:p>","DOI":"10.1093\/bioinformatics\/15.3.228","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T22:43:27Z","timestamp":1027723407000},"page":"228-233","source":"Crossref","is-referenced-by-count":53,"title":["A novel method for automatic functional annotation of proteins."],"prefix":"10.1093","volume":"15","author":[{"given":"W","family":"Fleischmann","sequence":"first","affiliation":[]},{"given":"S","family":"M\u221a\u2202ller","sequence":"additional","affiliation":[]},{"given":"A","family":"Gateau","sequence":"additional","affiliation":[]},{"given":"R","family":"Apweiler","sequence":"additional","affiliation":[]}],"member":"286","published-online":{"date-parts":[[1999,3,1]]},"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/15\/3\/228\/48835078\/bioinformatics_15_3_228.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/15\/3\/228\/48835078\/bioinformatics_15_3_228.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T05:45:24Z","timestamp":1674539124000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/15\/3\/228\/317280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1999,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/15.3.228","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[1999,3]]},"published":{"date-parts":[[1999,3,1]]}}}