乐胖代购免代理版

{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T18:33:09Z","timestamp":1732041189004},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19H04208","19F19377"],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["U19AG05537301","R01AR069055"],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,10]]},"abstract":"Abstract<\/jats:title>N6-methyladenine (6mA) is associated with important roles in DNA replication, DNA repair, transcription, regulation of gene expression. Several experimental methods were used to identify DNA modifications. However, these experimental methods are costly and time-consuming. To detect the 6mA and complement these shortcomings of experimental methods, we proposed a novel, deep leaning approach called BERT6mA. To compare the BERT6mA with other deep learning approaches, we used the benchmark datasets including 11 species. The BERT6mA presented the highest AUCs in eight species in independent tests. Furthermore, BERT6mA showed higher and comparable performance with the state-of-the-art models while the BERT6mA showed poor performances in a few species with a small sample size. To overcome this issue, pretraining and fine-tuning between two species were applied to the BERT6mA. The pretrained and fine-tuned models on specific species presented higher performances than other models even for the species with a small sample size. In addition to the prediction, we analyzed the attention weights generated by BERT6mA to reveal how the BERT6mA model extracts critical features responsible for the 6mA prediction. To facilitate biological sciences, the BERT6mA online web server and its source codes are freely accessible at https:\/\/github.com\/kuratahiroyuki\/BERT6mA.git, respectively.<\/jats:p>","DOI":"10.1093\/bib\/bbac053","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T20:10:51Z","timestamp":1643746251000},"source":"Crossref","is-referenced-by-count":31,"title":["BERT6mA: prediction of DNA N6-methyladenine site using deep learning-based approaches"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"http:\/\/orcid.org\/0000-0002-7871-0868","authenticated-orcid":false,"given":"Sho","family":"Tsukiyama","sequence":"first","affiliation":[{"name":"Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, 680-4 Kawazu, Iizuka, Fukuoka 820-8502, Japan"}]},{"ORCID":"http:\/\/orcid.org\/0000-0003-4952-0739","authenticated-orcid":false,"given":"Md Mehedi","family":"Hasan","sequence":"additional","affiliation":[{"name":"Tulane Center for Biomedical Informatics and Genomics, Division of Biomedical Informatics and Genomics, John W. Deming Department of Medicine, School of Medicine, Tulane University, New Orleans, LA 70112, USA"}]},{"given":"Hong-Wen","family":"Deng","sequence":"additional","affiliation":[{"name":"Tulane Center for Biomedical Informatics and Genomics, Division of Biomedical Informatics and Genomics, John W. Deming Department of Medicine, School of Medicine, Tulane University, New Orleans, LA 70112, USA"}]},{"ORCID":"http:\/\/orcid.org\/0000-0003-4254-2214","authenticated-orcid":false,"given":"Hiroyuki","family":"Kurata","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, 680-4 Kawazu, Iizuka, Fukuoka 820-8502, Japan"}]}],"member":"286","published-online":{"date-parts":[[2022,2,28]]},"reference":[{"key":"2022031506403542400_ref1","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.cbpa.2012.10.002","article-title":"Nucleic acid modifications with epigenetic significance","volume":"16","author":"Fu","year":"2012","journal-title":"Curr Opin Chem Biol"},{"key":"2022031506403542400_ref2","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/0092-8674(90)90271-F","article-title":"Coli oriC and the dnaA gene promoter are sequestered from dam methyltransferase following the passage of the chromosomal 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