{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,4]],"date-time":"2024-08-04T02:29:09Z","timestamp":1722738549378},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,7]],"date-time":"2014-10-07T00:00:00Z","timestamp":1412640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000629","name":"Age UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000629","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UK Medical Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Centre for Cognitive Ageing and Cognitive Epidemiology","award":["G0700704\/84698"]},{"name":"SINAPSE"},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council (BBSRC)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council (EPSRC)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000269","name":"Economic and Social Research Council (ESRC)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000269","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.neuroimage.2014.10.001","type":"journal-article","created":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T04:34:20Z","timestamp":1413261260000},"page":"332-346","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Automated segmentation of multifocal basal ganglia T2*-weighted MRI hypointensities"],"prefix":"10.1016","volume":"105","author":[{"given":"Andreas","family":"Glatz","sequence":"first","affiliation":[]},{"given":"Mark E.","family":"Bastin","sequence":"additional","affiliation":[]},{"given":"Alexander J.","family":"Kiker","sequence":"additional","affiliation":[]},{"given":"Ian J.","family":"Deary","sequence":"additional","affiliation":[]},{"given":"Joanna M.","family":"Wardlaw","sequence":"additional","affiliation":[]},{"given":"Maria C.","family":"Vald\u00e9s Hern\u00e1ndez","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.neuroimage.2014.10.001_bb0005","doi-asserted-by":"crossref","first-page":"4815","DOI":"10.1109\/IEMBS.2006.259516","article-title":"Image quality assessment based on local variance","volume":"1","author":"Aja-Fern\u00e1ndez","year":"2006","journal-title":"Conf. Proc. IEEE Eng. Med. Biol. Soc."},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0010","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1148\/radiol.2522081399","article-title":"Age-related iron deposition in the basal ganglia: quantitative analysis in healthy subjects","volume":"252","author":"Aquino","year":"2009","journal-title":"Radiology"},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0015","series-title":"Data Mining and Knowledge Discovery Handbook","article-title":"Outlier detection","author":"Ben-Gal","year":"2010"},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0020","first-page":"281","article-title":"Random search for hyper-parameter optimization","volume":"13","author":"Bergstra","year":"2012","journal-title":"J. Mach. Learn. Res."},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0025","series-title":"Handbook of MRI Pulse Sequences","author":"Bernstein","year":"2004"},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0030","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0140-6736(86)90837-8","article-title":"Statistical methods for assessing agreement between two methods of clinical measurement","volume":"1","author":"Bland","year":"1986","journal-title":"Lancet"},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0035","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/mrm.10505","article-title":"On the artifact of a subvoxel susceptibility deviation in spoiled gradient-echo imaging","volume":"50","author":"Bos","year":"2003","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0040","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/01.rmr.0000245459.82782.e4","article-title":"Magnetic resonance imaging of iron deposition in neurological disorders","volume":"17","author":"Brass","year":"2006","journal-title":"Top. Magn. Reson. Imaging"},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0045","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0165-1781(03)00202-6","article-title":"Mineralization of the basal ganglia: implications for neuropsychiatry, pathology and neuroimaging","volume":"121","author":"Casanova","year":"2003","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0055","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1471-2318-7-28","article-title":"The Lothian Birth Cohort 1936: a study to examine influences on cognitive ageing from age 11 to age 70 and beyond","volume":"7","author":"Deary","year":"2007","journal-title":"BMC Geriatr."},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0050","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1093\/ije\/dyr197","article-title":"Cohort profile: the Lothian Birth Cohorts of 1921 and 1936","volume":"41","author":"Deary","year":"2012","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0060","doi-asserted-by":"crossref","first-page":"127","DOI":"10.17713\/ajs.v34i2.406","article-title":"Identification of multivariate outliers: a performance study","volume":"34","author":"Filzmoser","year":"2005","journal-title":"Austrian J. Stat."},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0065","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.cageo.2004.11.013","article-title":"Multivariate outlier detection in exploration geochemistry","volume":"31","author":"Filzmoser","year":"2005","journal-title":"Comput. Geosci."},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0070","doi-asserted-by":"crossref","first-page":"N261","DOI":"10.1088\/0031-9155\/44\/12\/403","article-title":"A comparison of two methods for measuring the signal to noise ratio on MR images","volume":"44","author":"Firbank","year":"1999","journal-title":"Phys. Med. Biol."},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0075","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1198\/016214502760047131","article-title":"Model-based clustering, discriminant analysis, and density estimation","volume":"97","author":"Fraley","year":"2002","journal-title":"JASA"},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0080","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.neuroimage.2013.06.013","article-title":"Characterisation of multifocal T2*-weighted MRI hypointensities in the basal ganglia of elderly, community-dwelling subjects","volume":"82","author":"Glatz","year":"2013","journal-title":"NeuroImage"},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0085","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1002\/mrm.1910340618","article-title":"The Rician distribution of noisy MRI data","volume":"34","author":"Gudbjartsson","year":"1995","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mri.2004.10.001","article-title":"Imaging iron stores in the brain using magnetic resonance imaging","volume":"23","author":"Haacke","year":"2005","journal-title":"Magn. Reson. Imaging"},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0095","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1471-4159.1958.tb12607.x","article-title":"The effect of age on the non-haemin iron in the human brain","volume":"3","author":"Hallgren","year":"1958","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0100","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3174\/ajnr.A0770","article-title":"Mineralization of the deep gray matter with age: a retrospective review with susceptibility-weighted MR imaging","volume":"29","author":"Harder","year":"2008","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0105","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1198\/106186005X77685","article-title":"The distribution of robust distances","volume":"14","author":"Hardin","year":"2005","journal-title":"J. Comput. Graph. Stat."},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0110","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1148\/radiology.179.1.1848714","article-title":"High signal intensity in MR images of calcified brain tissue","volume":"179","author":"Henkelman","year":"1991","journal-title":"Radiology"},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0115","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/nan.12062","article-title":"Brain haemosiderin in older people: pathological evidence for an ischaemic origin of MRI microbleeds","volume":"3","author":"Janaway","year":"2014","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0120","first-page":"2647","article-title":"Automatic detection and classification of hypointensity in MR images of the brain","volume":"14","author":"Jasinschi","year":"2006","journal-title":"Proc. ISMRM"},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0125","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1006\/nimg.2002.1132","article-title":"Improved optimization for the robust and accurate linear registration and motion correction of brain images","volume":"17","author":"Jenkinson","year":"2002","journal-title":"NeuroImage"},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0130","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1257\/jep.15.4.143","article-title":"Quantile regression","volume":"15","author":"Koenker","year":"2001","journal-title":"J. Econ. Perspect."},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0135","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1002\/hbm.22360","article-title":"Differential developmental trajectories of magnetic susceptibility in human brain gray and white matter over the lifespan","volume":"35","author":"Li","year":"2014","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.neuroimage.2014.10.001_bb9005","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1002\/mrm.22745","article-title":"Iron quantification of microbleeds in postmortem brain","volume":"65","author":"McAuley","year":"2011","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0140","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1159\/000147312","article-title":"Histochemical distribution of non-haem iron in the human brain","volume":"144","author":"Morris","year":"1992","journal-title":"Acta Anat. (Basel)"},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0145","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/S0278-5846(97)00162-0","article-title":"A new MRI ratio method for in-vivo estimation of signal hypointensity in aging and Alzheimer's disease","volume":"21","author":"Parsey","year":"1997","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0150","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.neuroimage.2011.02.046","article-title":"A Bayesian model of shape and appearance for subcortical brain","volume":"56","author":"Patenaude","year":"2011","journal-title":"NeuroImage"},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0155","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.neurobiolaging.2010.04.032","article-title":"Brain iron deposits are associated with general cognitive ability and cognitive aging","volume":"33","author":"Penke","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0160","doi-asserted-by":"crossref","first-page":"4707","DOI":"10.1088\/0031-9155\/51\/18\/016","article-title":"Geometry and extension of signal voids in MR images induced by aggregations of magnetically labelled cells","volume":"51","author":"Pintaske","year":"2006","journal-title":"Phys. Med. Biol."},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0165","first-page":"169","article-title":"Evaluation of accuracy in partial volume analysis of small objects","volume":"6914","author":"Rexilius","year":"2008"},{"key":"10.1016\/j.neuroimage.2014.10.001_bb9000","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1080\/00401706.1999.10485670","article-title":"A Fast Algorithm for the Minimum Covariance Determinant Estimator","volume":"41","author":"Rousseeuw","year":"1999","journal-title":"Technometrics"},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0175","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1080\/01621459.1990.10474920","article-title":"Unmasking multivariate outliers and leverage points","volume":"85","author":"Rousseeuw","year":"1990","journal-title":"J. Am. Stat. Assoc."},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0180","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0022-510X(02)00431-8","article-title":"Magnetic resonance imaging of brain iron","volume":"207","author":"Schenck","year":"2003","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0185","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/nbm.922","article-title":"High-field magnetic resonance imaging of brain iron: birth of a biomarker?","volume":"17","author":"Schenck","year":"2004","journal-title":"NMR Biomed."},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0190","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.neuroimage.2013.08.051","article-title":"Reversible, irreversible and effective transverse relaxation rates in normal aging brain at 3T","volume":"84","author":"Sedlacik","year":"2014","journal-title":"NeuroImage"},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0195","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.neuroimage.2008.10.066","article-title":"Online resource for validation of brain segmentation methods","volume":"45","author":"Shattuck","year":"2009","journal-title":"NeuroImage"},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0200","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/00005072-195610000-00005","article-title":"The incidence, composition, and pathological significance of intracerebral vascular deposits in the basal ganglia","volume":"15","author":"Slager","year":"1956","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0205","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/hbm.10062","article-title":"Fast robust automated brain extraction","volume":"17","author":"Smith","year":"2002","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0210","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1109\/TMI.2010.2046908","article-title":"N4ITK: improved N3 bias correction","volume":"29","author":"Tustison","year":"2010","journal-title":"IEEE Trans. Med. Imaging"},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0220","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1007\/s00330-010-1718-6","article-title":"New multispectral MRI data fusion technique for white matter lesion segmentation: method and comparison with thresholding in FLAIR images","volume":"20","author":"Vald\u00e9s Hern\u00e1ndez","year":"2010","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0225","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/jmri.22361","article-title":"Reliability of two techniques for assessing cerebral iron deposits from structural MRI","volume":"33","author":"Vald\u00e9s Hern\u00e1ndez","year":"2011","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0230","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1007\/s00330-012-2494-2","article-title":"Identification of mineral deposits in the brain on radiological images: a systematic review","volume":"22","author":"Vald\u00e9s Hern\u00e1ndez","year":"2012","journal-title":"Eur. Radiol."},{"issue":"2","key":"10.1016\/j.neuroimage.2014.10.001_bb0215","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/jmri.24348","article-title":"Differentiation of calcified regions and iron deposits in the ageing brain on conventional structural MR images","volume":"40","author":"Vald\u00e9s Hernand\u00e9z","year":"2014","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0260","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1016\/j.neurobiolaging.2007.05.008","article-title":"Caudate nucleus hypointensity in the elderly is associated with markers of neurodegeneration on MRI","volume":"29","author":"van Es","year":"2008","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0235","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.chemolab.2004.06.003","article-title":"LIBRA: a Matlab library for robust analysis","volume":"75","author":"Verboven","year":"2005","journal-title":"Chemometr. Intell. Lab. Syst."},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0240","first-page":"835","article-title":"Differentiation between hemosiderin-and ferritin-bound brain iron using nuclear magnetic resonance and magnetic resonance imaging","volume":"46","author":"Vymazal","year":"2000","journal-title":"Cell. Mol. Biol. (Noisy-le-grand)"},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0245","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/j.1747-4949.2011.00683.x","article-title":"Brain aging, cognition in youth and old age and vascular disease in the Lothian Birth Cohort 1936: rationale, design and methodology of the imaging protocol","volume":"6","author":"Wardlaw","year":"2011","journal-title":"Int. J. Stroke"},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0250","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1002\/mrm.1910310605","article-title":"Microscopic susceptibility variation and transverse relaxation: theory and experiment","volume":"31","author":"Weisskoff","year":"1994","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neuroimage.2014.10.001_bb0255","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.1016\/j.actbio.2010.03.034","article-title":"Alginate-controlled formation of nanoscale calcium carbonate and hydroxyapatite mineral phase within hydrogel networks","volume":"6","author":"Xie","year":"2010","journal-title":"Acta Biomater."}],"container-title":["NeuroImage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105381191400812X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105381191400812X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T01:00:28Z","timestamp":1565917228000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S105381191400812X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":53,"alternative-id":["S105381191400812X"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroimage.2014.10.001","relation":{},"ISSN":["1053-8119"],"issn-type":[{"value":"1053-8119","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Automated segmentation of multifocal basal ganglia T2*-weighted MRI hypointensities","name":"articletitle","label":"Article Title"},{"value":"NeuroImage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroimage.2014.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}