{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T06:42:25Z","timestamp":1721803345006},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003708","name":"Korea Institute of Science and Technology Information","doi-asserted-by":"crossref","award":["K-16-L03-C02-S02"],"id":[{"id":"10.13039\/501100003708","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Expert Systems with Applications"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.eswa.2017.05.042","type":"journal-article","created":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T05:31:23Z","timestamp":1494999083000},"page":"249-260","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Systematic identification of differential gene network to elucidate Alzheimer's disease"],"prefix":"10.1016","volume":"85","author":[{"given":"Chihyun","family":"Park","sequence":"first","affiliation":[]},{"given":"Youngmi","family":"Yoon","sequence":"additional","affiliation":[]},{"given":"Min","family":"Oh","sequence":"additional","affiliation":[]},{"given":"Seok Jong","family":"Yu","sequence":"additional","affiliation":[]},{"given":"Jaegyoon","family":"Ahn","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"issue":"13","key":"10.1016\/j.eswa.2017.05.042_bib0001","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1093\/bioinformatics\/btr283","article-title":"Integrative gene network construction for predicting a set of complementary prostate cancer genes","volume":"27","author":"Ahn","year":"2011","journal-title":"Bioinformatics"},{"issue":"4","key":"10.1016\/j.eswa.2017.05.042_bib0002","doi-asserted-by":"crossref","first-page":"559","DOI":"10.2174\/157015911798376190","article-title":"The neurotrophins and their role in AD","volume":"9","author":"Allen","year":"2011","journal-title":"Current Neuropharmacology"},{"issue":"3","key":"10.1016\/j.eswa.2017.05.042_bib0004","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120352","article-title":"Assembly and interrogation of alzheimer's disease genetic networks reveal novel regulators of progression","volume":"10","author":"Aubry","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.eswa.2017.05.042_bib0005","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3233\/JAD-2012-111223","article-title":"Genome-wide DNA methylation differences between late-onset Alzheimer's disease and cognitively normal controls in human frontal cortex","volume":"29","author":"Bakulski","year":"2012","journal-title":"Journal of Alzheimers Disease"},{"issue":"1","key":"10.1016\/j.eswa.2017.05.042_bib0006","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ng1934","article-title":"Systematic meta-analyses of Alzheimer disease genetic association studies: The AlzGene database","volume":"39","author":"Bertram","year":"2007","journal-title":"Nature Genetics"},{"issue":"2","key":"10.1016\/j.eswa.2017.05.042_bib0007","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.neuron.2010.10.013","article-title":"The genetics of Alzheimer disease: Back to the future","volume":"68","author":"Bertram","year":"2010","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.eswa.2017.05.042_bib0008","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jalz.2007.04.381","article-title":"Forecasting the global burden of Alzheimer's disease","volume":"3","author":"Brookmeyer","year":"2007","journal-title":"Alzheimers and Dementia"},{"issue":"1","key":"10.1016\/j.eswa.2017.05.042_bib0009","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0144052","article-title":"Network topology analysis of post-mortem brain microarrays identifies more alzheimer's related genes and micrornas and points to novel routes for fighting with the disease","volume":"11","author":"Chandrasekaran","year":"2016","journal-title":"PLoS One"},{"issue":"7186","key":"10.1016\/j.eswa.2017.05.042_bib0010","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nature06757","article-title":"Variations in DNA elucidate molecular networks that cause disease","volume":"452","author":"Chen","year":"2008","journal-title":"Nature"},{"issue":"220","key":"10.1016\/j.eswa.2017.05.042_bib0011","article-title":"The potential of epigenetic therapies in neurodegenerative diseases","volume":"5","author":"Copped\u00e8","year":"2014","journal-title":"Frontiers in Genetics"},{"issue":"Database issue","key":"10.1016\/j.eswa.2017.05.042_bib0012","doi-asserted-by":"crossref","first-page":"D472","DOI":"10.1093\/nar\/gkt1102","article-title":"The reactome pathway knowledgebase","volume":"42","author":"Croft","year":"2014","journal-title":"Nucleic Acids Research"},{"issue":"118","key":"10.1016\/j.eswa.2017.05.042_bib0013","article-title":"Estimating mutual information using B-spline functions\u2013an improved similarity measure for analyzing gene expression data","volume":"5","author":"Daub","year":"2004","journal-title":"BMC Bioinformatics"},{"issue":"7","key":"10.1016\/j.eswa.2017.05.042_bib0014","doi-asserted-by":"crossref","first-page":"e68664","DOI":"10.1371\/journal.pone.0068664","article-title":"Comparison of profile similarity measures for genetic interaction networks","volume":"8","author":"Deshpande","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.eswa.2017.05.042_bib0015","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.jmb.2006.06.038","article-title":"Linker histone H1 binds to disease associated amyloid-like fibrils","volume":"361","author":"Duce","year":"2006","journal-title":"Journal of Molecular Biology"},{"issue":"3","key":"10.1016\/j.eswa.2017.05.042_bib0016","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.nbd.2005.09.004","article-title":"Alzheimer's disease: MRNA expression profiles of multiple patients show alterations of genes involved with calcium signaling","volume":"21","author":"Emilsson","year":"2006","journal-title":"Neurobiology Disease"},{"key":"10.1016\/j.eswa.2017.05.042_bib0017","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neuropharm.2014.01.038","article-title":"Targeting histone-modifications in Alzheimer's disease. What is the evidence that this is a promising therapeutic avenue?","volume":"80","author":"Fischer","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.eswa.2017.05.042_bib0018","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nrneurol.2016.84","article-title":"Genetic variants in Alzheimer's disease\u2013molecular and brain network approaches","volume":"12","author":"Gaiteri","year":"2016","journal-title":"Nature Reviews Neurology"},{"issue":"8","key":"10.1016\/j.eswa.2017.05.042_bib0019","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1093\/bioinformatics\/bts106","article-title":"CentiLib: Comprehensive analysis and exploration of network centralities","volume":"28","author":"Gr\u00e4\u00dfler","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.eswa.2017.05.042_bib0020","doi-asserted-by":"crossref","first-page":"13295","DOI":"10.1038\/srep13295","article-title":"Functional analysis and characterization of differential coexpression networks","volume":"5","author":"Hsu","year":"2015","journal-title":"Scientific Reports"},{"issue":"1","key":"10.1016\/j.eswa.2017.05.042_bib0022","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1242\/dmm.012146","article-title":"Selective vulnerability to neurodegenerative disease: The curious case of prion protein","volume":"7","author":"Jackson","year":"2014","journal-title":"Disease Model Mechanisms"},{"issue":"9","key":"10.1016\/j.eswa.2017.05.042_bib0023","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1038\/nn.3786","article-title":"AD: Early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci","volume":"17","author":"Jager","year":"2014","journal-title":"Nature Neuroscience"},{"issue":"8","key":"10.1016\/j.eswa.2017.05.042_bib0024","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1038\/nm.2828","article-title":"Epigenetic mechanisms in neurodevelopmental and neurodegenerative disease","volume":"18","author":"Jakovcevski","year":"2012","journal-title":"Nature Medicine"},{"issue":"7","key":"10.1016\/j.eswa.2017.05.042_bib0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003731","article-title":"iRegulon: From a gene list to a gene regulatory network using large motif and track collections","volume":"10","author":"Janky","year":"2014","journal-title":"PLoS Computational Biology"},{"issue":"15","key":"10.1016\/j.eswa.2017.05.042_bib0027","doi-asserted-by":"crossref","first-page":"5969","DOI":"10.1523\/JNEUROSCI.4668-14.2015","article-title":"Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease","volume":"35","author":"Kan","year":"2015","journal-title":"Journal of Neuroscience"},{"issue":"1","key":"10.1016\/j.eswa.2017.05.042_bib0028","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/j.eswa.2017.05.042_bib0029","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkr1088","article-title":"The IntAct molecular interaction database in 2012","volume":"40","author":"Kerrien","year":"2012","journal-title":"Nucleic Acids Research"},{"issue":"1","key":"10.1016\/j.eswa.2017.05.042_bib0030","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1365-2249.2010.04280.x","article-title":"Do ribosomopathies explain some cases of common variable immunodeficiency?","volume":"163","author":"Khan","year":"2011","journal-title":"Clinical and Experimental Immunology"},{"issue":"7","key":"10.1016\/j.eswa.2017.05.042_bib0031","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nrn2168","article-title":"Intracellular amyloid-bold beta in Alzheimer's disease","volume":"8","author":"LaFerla","year":"2007","journal-title":"Nature Reviews Neuroscience"},{"issue":"7","key":"10.1016\/j.eswa.2017.05.042_bib0032","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1101\/gr.118992.110","article-title":"Prioritizing candidate disease genes by network-based boosting of genome-wide association data","volume":"21","author":"Lee","year":"2011","journal-title":"Genome research"},{"issue":"10","key":"10.1016\/j.eswa.2017.05.042_bib0033","doi-asserted-by":"crossref","first-page":"649","DOI":"10.5483\/BMBRep.2010.43.10.649","article-title":"Epigenetic modification is linked to Alzheimer's disease: Is it a maker or a marker","volume":"43","author":"Lee","year":"2010","journal-title":"BMB Report"},{"issue":"7","key":"10.1016\/j.eswa.2017.05.042_bib0034","doi-asserted-by":"crossref","first-page":"e40498","DOI":"10.1371\/journal.pone.0040498","article-title":"Concerted perturbation observed in a hub network in Alzheimer's disease","volume":"7","author":"Liang","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.eswa.2017.05.042_bib0035","doi-asserted-by":"crossref","first-page":"e59","DOI":"10.1038\/cti.2015.41","article-title":"Common variable immunodeficiency associated with microdeletion of chromosome 1q42.1-q42.3 and inositol 1,4,5-trisphosphate kinase B (ITPKB) deficiency","volume":"5","author":"Louis","year":"2016","journal-title":"Clinical and Translational Immunology"},{"issue":"2","key":"10.1016\/j.eswa.2017.05.042_bib0036","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1385\/NMM:5:2:147","article-title":"Differential expression of oxidative phosphorylation genes in patients with Alzheimer's disease: Implications for early mitochondrial dysfunction and oxidative damage","volume":"5","author":"Manczak","year":"2004","journal-title":"Neuromolecular medicine"},{"issue":"6","key":"10.1016\/j.eswa.2017.05.042_bib0037","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/0006-3223(93)90182-D","article-title":"Antihistone and anti-dsDNA autoantibodies in Alzheimer's disease and vascular dementia","volume":"34","author":"Mecocci","year":"1993","journal-title":"Biological Psychiatry"},{"issue":"743","key":"10.1016\/j.eswa.2017.05.042_bib0038","article-title":"Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases","volume":"10","author":"Narayanan","year":"2014","journal-title":"Molecular Systems Biology"},{"issue":"1","key":"10.1016\/j.eswa.2017.05.042_bib0039","doi-asserted-by":"crossref","first-page":"e86309","DOI":"10.1371\/journal.pone.0086309","article-title":"Integrative gene network construction to analyze cancer recurrence using semi-supervised learning","volume":"9","author":"Park","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.eswa.2017.05.042_bib0040","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1006\/abbi.1993.1374","article-title":"Interaction between the beta-amyloid peptide precursor and histones","volume":"304","author":"Potempska","year":"1993","journal-title":"Archives of Biochemistry and Biophysics"},{"issue":"1064","key":"10.1016\/j.eswa.2017.05.042_bib0041","article-title":"Alternative \u03b1-synuclein transcript usage as a convergent mechanism in Parkinson's disease pathology","volume":"3","author":"Rhinn","year":"2012","journal-title":"Nature Communications"},{"issue":"7","key":"10.1016\/j.eswa.2017.05.042_bib0042","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Research"},{"issue":"5","key":"10.1016\/j.eswa.2017.05.042_bib0043","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.cell.2014.10.050","article-title":"A proteome-scale map of the human interactome network","volume":"159","author":"Rolland","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.eswa.2017.05.042_bib0044","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3389\/fnbeh.2015.00347","article-title":"Epigenetic alterations in Alzheimer's disease","volume":"9","author":"Sanchez-Mut","year":"2015","journal-title":"Frontiers in Behavioral Neuroscience"},{"issue":"12","key":"10.1016\/j.eswa.2017.05.042_bib0045","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.molmed.2014.10.002","article-title":"A network approach to clinical intervention in neurodegenerative diseases","volume":"20","author":"Santiago","year":"2014","journal-title":"Trends In Molecular Medicine"},{"issue":"104","key":"10.1016\/j.eswa.2017.05.042_bib0046","article-title":"DREM 2.0: Improved reconstruction of dynamic regulatory networks from time-series expression data","volume":"6","author":"Schulz","year":"2012","journal-title":"BMC Systems Biology"},{"issue":"199","key":"10.1016\/j.eswa.2017.05.042_bib0047","article-title":"Genomic convergence and network analysis approach to identify candidate genes in Alzheimer's disease","volume":"15","author":"Talwar","year":"2014","journal-title":"BMC Genomics [Electronic Resource]"},{"issue":"3","key":"10.1016\/j.eswa.2017.05.042_bib0048","doi-asserted-by":"crossref","first-page":"7070","DOI":"10.1016\/j.cell.2013.03.030","article-title":"Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease","volume":"153","author":"Zhang","year":"2013","journal-title":"Cell"}],"container-title":["Expert Systems with Applications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0957417417303615?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0957417417303615?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T19:06:29Z","timestamp":1569351989000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0957417417303615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":45,"alternative-id":["S0957417417303615"],"URL":"https:\/\/doi.org\/10.1016\/j.eswa.2017.05.042","relation":{},"ISSN":["0957-4174"],"issn-type":[{"value":"0957-4174","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systematic identification of differential gene network to elucidate Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Expert Systems with Applications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eswa.2017.05.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}