{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T21:03:53Z","timestamp":1725311033511},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computers in Biology and Medicine"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.compbiomed.2021.104971","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T10:51:27Z","timestamp":1635159087000},"page":"104971","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Computational validation of ABCB1 gene polymorphism and its effect on tacrolimus dose concentration\/levels in renal transplant individuals of South India"],"prefix":"10.1016","volume":"139","author":[{"given":"Haritha","family":"Mallina","sequence":"first","affiliation":[]},{"given":"Ramprasad","family":"Elumalai","sequence":"additional","affiliation":[]},{"given":"Solomon","family":"F D Paul","sequence":"additional","affiliation":[]},{"given":"C.","family":"George Priya Doss","sequence":"additional","affiliation":[]},{"given":"S.","family":"Udhaya Kumar","sequence":"additional","affiliation":[]},{"ORCID":"http:\/\/orcid.org\/0000-0002-4361-6679","authenticated-orcid":false,"given":"Gnanasambandan","family":"Ramanathan","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.compbiomed.2021.104971_bib1","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1056\/NEJMra011295","article-title":"Strategies to improve long-term outcomes after renal transplantation","volume":"346","author":"Pascual","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.compbiomed.2021.104971_bib2","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1056\/NEJMra033540","article-title":"Immunosuppressive drugs for kidney transplantation","volume":"351","author":"Halloran","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.compbiomed.2021.104971_bib3","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1111\/j.1600-6143.2006.01270.x","article-title":"Immunosuppression: evolution in practice and trends, 1994-2004","volume":"6","author":"Meier-Kriesche","year":"2006","journal-title":"Am. J. Transplant. : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons"},{"key":"10.1016\/j.compbiomed.2021.104971_bib4","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1111\/j.1600-6143.2006.01360.x","article-title":"Cyclosporin versus tacrolimus as primary immunosuppressant after liver transplantation: a meta-analysis","volume":"6","author":"McAlister","year":"2006","journal-title":"Am. J. Transplant. : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons"},{"key":"10.1016\/j.compbiomed.2021.104971_bib5","first-page":"764","article-title":"A systematic review of the adverse effects of tacrolimus in organ transplant patients","volume":"4","author":"D","year":"2011","journal-title":"African Journal of Pharmacy and Pharmacology"},{"key":"10.1016\/j.compbiomed.2021.104971_bib6","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1097\/MOT.0b013e3283193bc5","article-title":"Individualization of immunosuppression: concepts and rationale","volume":"13","author":"Wavamunno","year":"2008","journal-title":"Curr. Opin. Organ Transplant."},{"key":"10.1016\/j.compbiomed.2021.104971_bib7","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1093\/clinchem\/48.10.1668","article-title":"CYP3A5 variant allele frequencies in Dutch Caucasians","volume":"48","author":"van Schaik","year":"2002","journal-title":"Clin. Chem."},{"key":"10.1016\/j.compbiomed.2021.104971_bib8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1177\/1078155209104380","article-title":"Clinical significance of ABCB1 genotyping in oncology","volume":"16","author":"Hamidovic","year":"2010","journal-title":"J. Oncol. Pharm. Pract. : official publication of the International Society of Oncology Pharmacy Practitioners"},{"key":"10.1016\/j.compbiomed.2021.104971_bib9","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.biopha.2016.02.028","article-title":"ABCB1 variants confer susceptibility to primary open-angle glaucoma and predict individual differences to latanoprost treatment","volume":"80","author":"Liu","year":"2016","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"key":"10.1016\/j.compbiomed.2021.104971_bib10","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1016\/j.transproceed.2006.08.089","article-title":"Tacrolimus dosing in Chinese renal transplant patients is related to MDR1 gene C3435T polymorphisms","volume":"38","author":"Li","year":"2006","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.compbiomed.2021.104971_bib11","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/bdd.697","article-title":"Simulation of sirolimus exposures and population variability immediately post renal transplantation: importance of the patient's CYP3A5 genotype in tailoring treatment","volume":"31","author":"Lukas","year":"2010","journal-title":"Biopharm Drug Dispos."},{"key":"10.1016\/j.compbiomed.2021.104971_bib12","doi-asserted-by":"crossref","first-page":"146","DOI":"10.4103\/0971-4065.70846","article-title":"Effect of gene polymorphisms on the levels of calcineurin inhibitors in Indian renal transplant recipients","volume":"20","author":"Ashavaid","year":"2010","journal-title":"Indian J. Nephrol."},{"key":"10.1016\/j.compbiomed.2021.104971_bib13","first-page":"9","article-title":"Pavani upendram, tarun kumar saha, pragna rao and qurratulain hasan influence of gene polymorphism on the pharamacokinetics of calcineurin inhibitors: in renal transplant patients from India","volume":"3","author":"Kiran Kumar Vattam","year":"2013","journal-title":"International Research Journal of Pharmacy and Pharmacology"},{"key":"10.1016\/j.compbiomed.2021.104971_bib14","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1111\/j.1432-2277.2005.00191.x","article-title":"Evolution of tacrolimus blood levels and concentration-dose ratios in patients who develop new onset diabetes mellitus after kidney transplantation","volume":"18","author":"Rodrigo","year":"2005","journal-title":"Transpl. Int. : official journal of the European Society for Organ Transplantation"},{"key":"10.1016\/j.compbiomed.2021.104971_bib15","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s00228-011-1150-0","article-title":"The interactions of age, sex, body mass index, genetics, and steroid weight-based doses on tacrolimus dosing requirement after adult kidney transplantation","volume":"68","author":"Stratta","year":"2012","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.compbiomed.2021.104971_bib16","doi-asserted-by":"crossref","first-page":"167","DOI":"10.12659\/AOT.895898","article-title":"Tacrolimus concentration\/dose ratio is associated with renal function after liver transplantation","volume":"21","author":"Tholking","year":"2016","journal-title":"Ann. Transplant."},{"key":"10.1016\/j.compbiomed.2021.104971_bib17","series-title":"Molecular Cloning : a Laboratory Manual","author":"Sambrook","year":"2001"},{"issue":"Suppl 2","key":"10.1016\/j.compbiomed.2021.104971_bib18","first-page":"S5","article-title":"iStable: off-the-shelf predictor integration for predicting protein stability changes","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.compbiomed.2021.104971_bib19","doi-asserted-by":"crossref","first-page":"W306","DOI":"10.1093\/nar\/gki375","article-title":"I-Mutant2.0: predicting stability changes upon mutation from the protein sequence or structure","volume":"33","author":"Capriotti","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiomed.2021.104971_bib20","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1002\/prot.20810","article-title":"Prediction of protein stability changes for single-site mutations using support vector machines","volume":"62","author":"Cheng","year":"2006","journal-title":"Proteins"},{"key":"10.1016\/j.compbiomed.2021.104971_bib21","doi-asserted-by":"crossref","first-page":"W229","DOI":"10.1093\/nar\/gkx439","article-title":"SDM: a server for predicting effects of mutations on protein stability","volume":"45","author":"Pandurangan","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiomed.2021.104971_bib22","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/bioinformatics\/btt691","article-title":"mCSM: predicting the effects of mutations in proteins using graph-based signatures","volume":"30","author":"Pires","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.compbiomed.2021.104971_bib23","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera--a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.compbiomed.2021.104971_bib24","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1093\/bioinformatics\/btt607","article-title":"Protter: interactive protein feature visualization and integration with experimental proteomic data","volume":"30","author":"Omasits","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.compbiomed.2021.104971_bib25","doi-asserted-by":"crossref","first-page":"D115","DOI":"10.1093\/nar\/gkh131","article-title":"UniProt: the universal protein knowledgebase","volume":"32","author":"Apweiler","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiomed.2021.104971_bib26","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/00008571-200208000-00005","article-title":"C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation","volume":"12","author":"Goto","year":"2002","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.compbiomed.2021.104971_bib27","first-page":"775","volume":"12","author":"Wei-lin","year":"2006"},{"key":"10.1016\/j.compbiomed.2021.104971_bib28","first-page":"1093","article-title":"Influence of CYP3A5 and ABCB1 gene polymorphisms and other factors on tacrolimus dosing in Caucasian liver and kidney transplant patients","volume":"28","author":"Provenzani","year":"2011","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.compbiomed.2021.104971_bib29","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1093\/hmg\/ddh099","article-title":"Genomic evidence for recent positive selection at the human MDR1 gene locus","volume":"13","author":"Tang","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.compbiomed.2021.104971_bib30","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/00008571-200208000-00004","article-title":"Distinct haplotype profiles and strong linkage disequilibrium at the MDR1 multidrug transporter gene locus in three ethnic Asian populations","volume":"12","author":"Tang","year":"2002","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.compbiomed.2021.104971_bib31","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1067\/mcp.2001.114164","article-title":"Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects","volume":"69","author":"Cascorbi","year":"2001","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.compbiomed.2021.104971_bib32","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1111\/j.1600-6143.2006.01518.x","article-title":"CYP3A5 and ABCB1 polymorphisms and tacrolimus pharmacokinetics in renal transplant candidates: guidelines from an experimental study","volume":"6","author":"Haufroid","year":"2006","journal-title":"Am. J. Transplant. : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons"},{"key":"10.1016\/j.compbiomed.2021.104971_bib33","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.1742-7843.2008.00327.x","article-title":"Influence of CYP3A5 genetic polymorphism on tacrolimus daily dose requirements and acute rejection in renal graft recipients","volume":"103","author":"Quteineh","year":"2008","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.compbiomed.2021.104971_bib34","first-page":"54","article-title":"Polymorphisms in CYP3A5*3 and MDR1, and haplotype modulate response to plasma levels of tacrolimus in Chinese renal transplant patients","volume":"16","author":"Wu","year":"2011","journal-title":"Ann. Transplant."},{"key":"10.1016\/j.compbiomed.2021.104971_bib35","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1186\/s40064-015-1425-5","article-title":"CYP3A5 and ABCB1 genotype influence tacrolimus and sirolimus pharmacokinetics in renal transplant recipients","volume":"4","author":"Li","year":"2015","journal-title":"SpringerPlus"},{"key":"10.1016\/j.compbiomed.2021.104971_bib36","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2131\/jts.41.143","article-title":"Effect of penicillin-based antibiotics, amoxicillin, ampicillin, and piperacillin, on drug-metabolizing activities of human hepatic cytochromes P450","volume":"41","author":"Niwa","year":"2016","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.compbiomed.2021.104971_bib37","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.transproceed.2008.04.010","article-title":"Significant impact of gene polymorphisms on tacrolimus but not cyclosporine dosing in Asian renal transplant recipients","volume":"40","author":"Loh","year":"2008","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.compbiomed.2021.104971_bib38","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1472-8206.2010.00917.x","article-title":"Genetic polymorphisms of drug-metabolizing phase I enzymes CYP2E1, CYP2A6 and CYP3A5 in South Indian population","volume":"26","author":"Krishnakumar","year":"2012","journal-title":"Fund. Clin. Pharmacol."},{"key":"10.1016\/j.compbiomed.2021.104971_bib39","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/00008571-200206000-00009","article-title":"Novel detection assay by PCR-RFLP and frequency of the CYP3A5 SNPs, CYP3A5*3 and *6, in a Japanese population","volume":"12","author":"Fukuen","year":"2002","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.compbiomed.2021.104971_bib40","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/86882","article-title":"Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression","volume":"27","author":"Kuehl","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.compbiomed.2021.104971_bib41","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0092-8674(86)90595-7","article-title":"Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells","volume":"47","author":"Chen","year":"1986","journal-title":"Cell"},{"key":"10.1016\/j.compbiomed.2021.104971_bib42","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s10038-002-8653-6","article-title":"Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB\/MDR\/TAP), in the Japanese population","volume":"47","author":"Saito","year":"2002","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.compbiomed.2021.104971_bib43","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/FPC.0b013e3283385a1c","article-title":"Very important pharmacogene summary: ABCB1 (MDR1, P-glycoprotein)","volume":"21","author":"Hodges","year":"2011","journal-title":"Pharmacogenetics Genom."},{"key":"10.1016\/j.compbiomed.2021.104971_bib44","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/bjc.2016.203","article-title":"ABCB1 (MDR1) induction defines a common resistance mechanism in paclitaxel- and olaparib-resistant ovarian cancer cells","volume":"115","author":"Vaidyanathan","year":"2016","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.compbiomed.2021.104971_bib45","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1097\/00008571-200208000-00002","article-title":"MDR1 single nucleotide polymorphisms: multiplicity of haplotypes and functional consequences","volume":"12","author":"Kim","year":"2002","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.compbiomed.2021.104971_bib46","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.clpt.2006.09.011","article-title":"ABCB1 genetic variability and methadone dosage requirements in opioid-dependent individuals","volume":"80","author":"Coller","year":"2006","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.compbiomed.2021.104971_bib47","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1097\/00008571-200308000-00006","article-title":"I. Pharmacogenetics of Membrane Transporters, Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene","volume":"13","author":"Kroetz","year":"2003","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.compbiomed.2021.104971_bib48","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1111\/papr.12546","article-title":"Relationship between ABCB1 polymorphisms and cold pain sensitivity among healthy opioid-naive Malay males, pain practice","volume":"17","author":"Zahari","year":"2017","journal-title":"the official journal of World Institute of Pain"},{"issue":"1","key":"10.1016\/j.compbiomed.2021.104971_bib49","doi-asserted-by":"crossref","first-page":"5235","DOI":"10.1038\/s41598-021-83696-x","article-title":"In silico screening and analysis of nonsynonymous SNPs in human CYP1A2 to assess possible associations with pathogenicity and cancer susceptibility","volume":"11","author":"Navapour","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.compbiomed.2021.104971_bib50","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s12013-020-00960-z","article-title":"Molecular dynamics, residue network analysis, and cross-correlation matrix to characterize the deleterious missense mutations in GALE causing galactosemia III","volume":"79","author":"Kumar","year":"2021","journal-title":"Cell Biochem. Biophys."},{"issue":"6","key":"10.1016\/j.compbiomed.2021.104971_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/prp2.538","article-title":"Systematic exploration of predicted destabilizing nonsynonymous single nucleotide polymorphisms (nsSNPs) of human aldehyde oxidase: A Bio\u2010informatics study","volume":"7","author":"Coelho","year":"2019","journal-title":"Pharmacol. Res. Perspect."},{"issue":"23","key":"10.1016\/j.compbiomed.2021.104971_bib52","article-title":"Deciphering the role of filamin B calponin-homology domain in causing the Larsen Syndrome, Boomerang Dysplasia, and Atelosteogenesis Type I Spectrum Disorders via a Computational Approach","volume":"25","author":"Kumar S","year":"2020","journal-title":"Molecules"}],"container-title":["Computers in Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010482521007654?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010482521007654?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T17:59:54Z","timestamp":1699725594000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0010482521007654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":52,"alternative-id":["S0010482521007654"],"URL":"https:\/\/doi.org\/10.1016\/j.compbiomed.2021.104971","relation":{},"ISSN":["0010-4825"],"issn-type":[{"value":"0010-4825","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Computational validation of ABCB1 gene polymorphism and its effect on tacrolimus dose concentration\/levels in renal transplant individuals of South India","name":"articletitle","label":"Article Title"},{"value":"Computers in Biology and Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.compbiomed.2021.104971","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"104971"}}