{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T04:19:49Z","timestamp":1744085989737},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computers in Biology and Medicine"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.compbiomed.2021.104261","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T17:41:54Z","timestamp":1612892514000},"page":"104261","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Finite element-based method for determining an optimal offloading design for treating and preventing heel ulcers"],"prefix":"10.1016","volume":"131","author":[{"ORCID":"http:\/\/orcid.org\/0000-0001-9774-4927","authenticated-orcid":false,"given":"Hadar","family":"Shaulian","sequence":"first","affiliation":[]},{"given":"Amit","family":"Gefen","sequence":"additional","affiliation":[]},{"given":"Deborah","family":"Solomonow-Avnon","sequence":"additional","affiliation":[]},{"given":"Alon","family":"Wolf","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.compbiomed.2021.104261_bib1","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/S0140-6736(05)67698-2","article-title":"The global burden of diabetic foot disease","volume":"366","author":"Boulton","year":"2005","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.compbiomed.2021.104261_bib2","doi-asserted-by":"crossref","first-page":"153","DOI":"10.4239\/wjd.v7.i7.153","article-title":"Diabetic foot disease: from the evaluation of the \u2018foot at risk\u2019 to the novel diabetic ulcer treatment modalities","volume":"7","author":"Amin","year":"2016","journal-title":"World J. Diabetes"},{"issue":"5","key":"10.1016\/j.compbiomed.2021.104261_bib3","doi-asserted-by":"crossref","first-page":"513","DOI":"10.2337\/diacare.13.5.513","article-title":"Pathways to diabetic basis for prevention","volume":"13","author":"Pecoraro","year":"1990","journal-title":"Diabetes Care"},{"issue":"2","key":"10.1016\/j.compbiomed.2021.104261_bib4","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1001\/jama.293.2.217","article-title":"Preventing foot ulcers in patients with diabetes","volume":"293","author":"Singh","year":"2005","journal-title":"J. Am. Med. Assoc."},{"issue":"Suppl","key":"10.1016\/j.compbiomed.2021.104261_bib5","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/dmrr.2245","article-title":"Cost of treating diabetic foot ulcers in five different countries","volume":"28","author":"Cavanagh","year":"2012","journal-title":"Diabetes. Metab. Res. Rev."},{"issue":"Suppl","key":"10.1016\/j.compbiomed.2021.104261_bib6","doi-asserted-by":"crossref","first-page":"5S","DOI":"10.1016\/S0002-9610(98)00181-0","article-title":"The burden of diabetic foot ulcers","volume":"176","author":"Reiber","year":"1998","journal-title":"Am. J. Surg."},{"key":"10.1016\/j.compbiomed.2021.104261_bib7","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S1056-8727(96)00125-0","article-title":"Options for diabetic patients with chronic heel ulcer","volume":"11","author":"Cevera","year":"1997","journal-title":"J. Diabet. Complicat."},{"key":"10.1016\/j.compbiomed.2021.104261_bib8","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1007\/BF00400259","article-title":"The risk of foot ulceration in diabetic patients with high foot pressure: a prospective study","volume":"35","author":"Veves","year":"1992","journal-title":"Diabetologia"},{"issue":"5","key":"10.1016\/j.compbiomed.2021.104261_bib9","doi-asserted-by":"crossref","first-page":"606","DOI":"10.2337\/diacare.23.5.606","article-title":"Screening techniques to identify people at high risk for diabetic foot ulceration: a prospective multicenter trial","volume":"23","author":"Pham","year":"2000","journal-title":"Diabetes Care"},{"key":"10.1016\/j.compbiomed.2021.104261_bib10","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.gaitpost.2018.08.013","article-title":"The effect of center of pressure alteration on the ground reaction force during gait: a statistical model","volume":"66","author":"Shaulian","year":"2018","journal-title":"Gait Posture"},{"key":"10.1016\/j.compbiomed.2021.104261_bib11","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1016\/j.jbiomech.2005.08.006","article-title":"Reduction of plantar heel pressures: insole design using finite element analysis","volume":"39","author":"Goske","year":"2006","journal-title":"J. Biomech."},{"issue":"3","key":"10.1016\/j.compbiomed.2021.104261_bib12","doi-asserted-by":"crossref","first-page":"37S","DOI":"10.1016\/j.jvs.2010.06.007","article-title":"Off-loading the diabetic foot for ulcer prevention and healing","volume":"52","author":"Cavanagh","year":"2010","journal-title":"J. Vasc. Surg."},{"issue":"4","key":"10.1016\/j.compbiomed.2021.104261_bib13","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.jaad.2018.12.068","article-title":"Pressure ulcers: prevention and management","volume":"81","author":"Mervis","year":"2019","journal-title":"J. Am. Acad. Dermatol."},{"issue":"11","key":"10.1016\/j.compbiomed.2021.104261_bib14","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.2337\/dc08-0771","article-title":"Use of pressure offloading devices in diabetic foot ulcers: do we practice what we preach?","volume":"31","author":"Wu","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1016\/j.compbiomed.2021.104261_bib15","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0891-8422(23)01031-5","article-title":"The edge effect: how and why wounds grow in size and depth","volume":"15","author":"Armstrong","year":"1998","journal-title":"Clin. Podiatr. Med. Surg."},{"key":"10.1016\/j.compbiomed.2021.104261_bib16","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S1350-4533(03)00029-8","article-title":"Plantar soft tissue loading under the medial metatarsals in the standing diabetic foot","volume":"25","author":"Gefen","year":"2003","journal-title":"Med. Eng. Phys."},{"key":"10.1016\/j.compbiomed.2021.104261_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jtv.2015.01.001","article-title":"The biomechanical efficacy of dressings in preventing heel ulcers","volume":"24","author":"Levy","year":"2015","journal-title":"J. Tissue Viability"},{"key":"10.1016\/j.compbiomed.2021.104261_bib18","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/S0268-0033(01)00047-X","article-title":"Stress distribution of the foot during midstance to push off in barefoot gait: a 3D finite element analysis","volume":"16","author":"Chen","year":"2001","journal-title":"Clin. Biomech."},{"key":"10.1016\/j.compbiomed.2021.104261_bib19","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.medengphy.2007.05.002","article-title":"Parametric design of pressure-relieving foot orthosis using statistics-based finite element method","volume":"30","author":"Cheung","year":"2008","journal-title":"Med. Eng. Phys."},{"key":"10.1016\/j.compbiomed.2021.104261_bib20","first-page":"350","article-title":"Pressure-sensing devices for assessment of soft tissue loading under bony prominences: technological concepts and clinical utilization","volume":"19","author":"Gefen","year":"2007","journal-title":"Wounds"},{"issue":"6","key":"10.1016\/j.compbiomed.2021.104261_bib21","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1111\/iwj.13203","article-title":"Modelling an adult human head on a donut\u2010shaped gel head support for pressure ulcer prevention","volume":"16","author":"Katzengold","year":"2019","journal-title":"Int. Wound J."},{"year":"2012","author":"Simpleware\u00ae Ltd","series-title":"ScanIP, +FE, +NURBS and +CAD Reference Guide Ver. 5.1","key":"10.1016\/j.compbiomed.2021.104261_bib22"},{"year":"2016","author":"FEBio","series-title":"Finite Element for Biomechanics, Theory Manual Ver. 2.5","key":"10.1016\/j.compbiomed.2021.104261_bib23"},{"key":"10.1016\/j.compbiomed.2021.104261_bib24","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3109\/03093649909071625","article-title":"In vivo friction properties of human skin","volume":"23","author":"Zhang","year":"1999","journal-title":"Prosthet. Orthot. Int."},{"key":"10.1016\/j.compbiomed.2021.104261_bib25","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1115\/1.1318904","article-title":"Biomechanical analysis of the three-dimensional foot structure during gait: a basic tool for clinical applications","volume":"122","author":"Gefen","year":"2000","journal-title":"J. Biomech. Eng."},{"issue":"9","key":"10.1016\/j.compbiomed.2021.104261_bib26","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/S0301-5629(01)00442-2","article-title":"Elastic properties of tendon measured by two different approaches","volume":"27","author":"Kuo","year":"2001","journal-title":"Ultrasound Med. Biol."},{"year":"1997","author":"Bonet","series-title":"Nonlinear Continuum Mechanics for Finite Element Analysis","key":"10.1016\/j.compbiomed.2021.104261_bib27"},{"issue":"5","key":"10.1016\/j.compbiomed.2021.104261_bib28","first-page":"289","article-title":"Role of EVA viscoelastic properties in the protective performance of a sport shoe: computational studies","volume":"16","author":"Even-Tzur","year":"2006","journal-title":"Bio Med. Mater. Eng."},{"key":"10.1016\/j.compbiomed.2021.104261_bib29","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1016\/S0021-9290(01)00143-9","article-title":"In vivo biomechanical behavior of the human heel pad during the stance phase of gait","volume":"34","author":"Gefen","year":"2001","journal-title":"J. Biomech."},{"issue":"B","key":"10.1016\/j.compbiomed.2021.104261_bib30","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1302\/0301-620X.76B1.8300659","article-title":"The heel pad in plantar heel pain","volume":"76","author":"Prichasuk","year":"1994","journal-title":"J. Bone Jt. Surg. [Br]"},{"key":"10.1016\/j.compbiomed.2021.104261_bib31","doi-asserted-by":"crossref","first-page":"11005-1","DOI":"10.1115\/1.4005694","article-title":"FEBio: finite elements for biomechanics","volume":"134","author":"Maas","year":"2012","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.compbiomed.2021.104261_bib32","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1046\/j.1464-5491.2001.00422.x","article-title":"\u201cThe effects of ulcer size and site, patient's age, sex and type and duration of diabetes on the outcome of diabetic foot ulcers","volume":"18","author":"Oyibo","year":"2001","journal-title":"Diabet. Med."},{"issue":"11","key":"10.1016\/j.compbiomed.2021.104261_bib33","article-title":"Reliability of the TekScan MatScan\u00ae system for the measurement of plantar forces and pressures during barefoot level walking in healthy adults","volume":"3","author":"Zammit","year":"2010","journal-title":"J. Foot Ankle Res."},{"key":"10.1016\/j.compbiomed.2021.104261_bib34","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s10237-017-0978-3","article-title":"Subject-specific finite element modelling of the human foot complex during walking: sensitivity analysis of material properties, boundary and loading conditions","volume":"17","author":"Akrami","year":"2018","journal-title":"Biomech. Model. Mechanobiol."},{"issue":"4","key":"10.1016\/j.compbiomed.2021.104261_bib35","first-page":"915","article-title":"Interaction, nonlinearity, and multicollinearity: implications for multiple regression","volume":"19","author":"Cortina","year":"1993","journal-title":"J. Manag."},{"issue":"2","key":"10.1016\/j.compbiomed.2021.104261_bib36","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/0141-5425(85)90040-8","article-title":"Foot pressure patterns during gait","volume":"7","author":"Soames","year":"1985","journal-title":"J. Biomed. Eng."},{"issue":"3","key":"10.1016\/j.compbiomed.2021.104261_bib37","first-page":"214","article-title":"Pressure redistribution by molded inserts in diabetic footwear: a pilot study","volume":"31","author":"Lord","year":"1994","journal-title":"J. Rehabil. Res. Dev."},{"issue":"6","key":"10.1016\/j.compbiomed.2021.104261_bib38","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/S0268-0033(03)00080-9","article-title":"Effects of total contact insoles on the plantar stress redistribution: a finite element analysis","volume":"18","author":"Chen","year":"2003","journal-title":"Clin. Biomech."},{"key":"10.1016\/j.compbiomed.2021.104261_bib39","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.medengphy.2016.11.003","article-title":"Estimating the material properties of heel pad sub-layers using inverse Finite Element Analysis","volume":"40","author":"Ahanchian","year":"2017","journal-title":"Med. Eng. Phys."},{"issue":"3","key":"10.1016\/j.compbiomed.2021.104261_bib40","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.gaitpost.2008.10.055","article-title":"Utilization of the foot load monitor for evaluating deep plantar tissue stresses in patients with diabetes: proof-of-concept studies","volume":"29","author":"Atlas","year":"2009","journal-title":"Gait Posture"},{"key":"10.1016\/j.compbiomed.2021.104261_bib41","series-title":"2019 IEEE 19th International Conference on Bioinformatics and Bioengineering","first-page":"352","article-title":"Automatic scoring of diabetic foot ulcers through deep CNN based feature extraction with low rank matrix factorization","author":"Gamage","year":"2019"},{"key":"10.1016\/j.compbiomed.2021.104261_bib42","series-title":"Moratuwa Engineering Research Conference","first-page":"686","article-title":"A smart telemedicine system with deep learning to manage diabetic retinopathy and foot ulcers","author":"Wijesinghe","year":"2019"},{"key":"10.1016\/j.compbiomed.2021.104261_bib43","doi-asserted-by":"crossref","first-page":"15655","DOI":"10.1007\/s11042-019-07820-w","article-title":"DFU_QUTNet: diabetic foot ulcer classification using novel deep convolutional neural network","volume":"79","author":"Alzubaidi","year":"2020","journal-title":"Multimed. Tool. Appl."},{"key":"10.1016\/j.compbiomed.2021.104261_bib44","first-page":"1","article-title":"Neuropathic ulcers: a focused review","author":"Urso","year":"2020","journal-title":"Int. J. Dermatol."}],"container-title":["Computers in Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001048252100055X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001048252100055X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T22:44:09Z","timestamp":1724453049000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001048252100055X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":44,"alternative-id":["S001048252100055X"],"URL":"https:\/\/doi.org\/10.1016\/j.compbiomed.2021.104261","relation":{},"ISSN":["0010-4825"],"issn-type":[{"type":"print","value":"0010-4825"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Finite element-based method for determining an optimal offloading design for treating and preventing heel ulcers","name":"articletitle","label":"Article Title"},{"value":"Computers in Biology and Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.compbiomed.2021.104261","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104261"}}