乐胖代购免代理版

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Biol."],"published-print":{"date-parts":[[2019,9]]},"abstract":"Background<\/jats:title>Common variable immunodeficiency (CVID), the most prevalent form of primary immunodeficiency (PID), is characterized by hypogammaglobulinemia and recurrent infections. Understanding protein\u2010protein interaction (PPI) networks of CVID genes and identifying candidate CVID genes are critical steps in facilitating the early diagnosis of CVID. Here, the aim was to investigate PPI networks of CVID genes and identify candidate CVID genes using computation techniques.<\/jats:p><\/jats:sec>Methods<\/jats:title>Network density and biological distance were used to study PPI data for CVID and PID genes obtained from the STRING database. Gene expression data of patients with CVID were obtained from the Gene Expression Omnibus, and then Pearson\u2019s correlation coefficient, a PPI database, and Kyoto Encyclopedia of Genes and Genomes were used to identify candidate CVID genes. We then evaluated our predictions and identified differentially expressed CVID genes.<\/jats:p><\/jats:sec>Results<\/jats:title>The majority of CVID genes are characterized by a high network density and small biological distance, whereas most PID genes are characterized by a low network density and large biological distance, indicating that CVID genes are more functionally similar to each other and closely interact with one other compared with PID genes. Subsequently, we identified 172 CVID candidate genes that have similar biological functions to known CVID genes, and eight genes were recently reported as CVID\u2010related genes. MYC, a candidate gene, was down\u2010regulated in CVID duodenal biopsies, but up\u2010regulated in blood samples compared with levels in healthy controls.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our findings will aid in a better understanding of the complex of CVID genes, possibly further facilitating the early diagnosis of CVID.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s40484-019-0174-9","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T14:17:10Z","timestamp":1562681830000},"page":"190-201","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Identification of candidate disease genes in patients with common variable immunodeficiency"],"prefix":"10.1002","volume":"7","author":[{"given":"Guojun","family":"Liu","sequence":"first","affiliation":[{"name":" Department of Medical Biochemistry and Biophysics Institute of Natural Sciences and Mathematics Ural Federal University Ekaterinburg 620000 Russia"}]},{"given":"Mikhail A.","family":"Bolkov","sequence":"additional","affiliation":[{"name":" Institute of Immunology and Physiology Ural Branch of the Russian Academy of Sciences Ekaterinburg 620000 Russia"},{"name":" Department of immunochemistry Institute of Chemical Engineering Ural Federal University Ekaterinburg 620000 Russia"}]},{"given":"Irina A.","family":"Tuzankina","sequence":"additional","affiliation":[{"name":" Institute of Immunology and Physiology Ural Branch of the Russian Academy of Sciences Ekaterinburg 620000 Russia"},{"name":" Department of immunochemistry Institute of Chemical Engineering Ural Federal University Ekaterinburg 620000 Russia"}]},{"given":"Irina G.","family":"Danilova","sequence":"additional","affiliation":[{"name":" Department of Medical Biochemistry and Biophysics Institute of Natural Sciences and Mathematics Ural Federal University Ekaterinburg 620000 Russia"},{"name":" Institute of Immunology and Physiology Ural Branch of 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Bolkov, Irina A. Tuzankina and Irina G. Danilova declare that they have no conflict of interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethics Guidelines"}},{"value":"All procedures performed in studies were in accordance with the ethical standards of the institution or practice at which the studies were conducted, and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethics Guidelines"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}