乐胖代购免代理版

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Biol."],"published-print":{"date-parts":[[2013,9]]},"abstract":"A central goal of synthetic biology is to apply successful principles that have been developed in electronic and chemical engineering to construct basic biological functional modules, and through rational design, to build synthetic biological systems with predetermined functions. Here, we apply the reverse engineering design principle of biological networks to synthesize a gene circuit that executes semi\u2010log dose\u2010response, a logarithmically linear sensing function, in Escherichia coli<\/jats:italic> cells. We first mathematically define the object function semi\u2010log dose\u2010response, and then search for tri\u2010node network topologies that can most robustly execute the object function. The simplest topology, transcriptional coherent feed\u2010forward loop (TCFL), among the searching results is mathematically analyzed; we find that, in TCFL topology, the semi\u2010log dose\u2010response function arises from the additive effect of logarithmical linearity intervals of Hill functions. TCFL is then genetically implemented in E. coli<\/jats:italic> as a logarithmically linear sensing biosensor for heavy metal ions [mercury (II)]. Functional characterization shows that this rationally designed biosensor circuit works as expected. Through this study we demonstrated the potential application of biological network reverse engineering to broaden the computational power of synthetic biology.<\/jats:p>","DOI":"10.1007\/s40484-013-0020-4","type":"journal-article","created":{"date-parts":[[2013,11,15]],"date-time":"2013-11-15T12:27:46Z","timestamp":1384518466000},"page":"209-220","source":"Crossref","is-referenced-by-count":5,"title":["Rational design of a biosensor circuit with semi\u2010log dose\u2010response function in Escherichia coli<\/i>"],"prefix":"10.1002","volume":"1","author":[{"given":"Haoqian","family":"Zhang","sequence":"first","affiliation":[{"name":" Peking University Team for the International Genetic Engineering Machine Competition (iGEM) Peking University Beijng 100871 China"},{"name":" Peking\u2010Tsinghua Joint Center for Life Sciences School of Life Sciences Peking University Beijing 100871 China"},{"name":" Center for Quantitative Biology Peking University Beijng 100871 China"}]},{"given":"Ying","family":"Sheng","sequence":"additional","affiliation":[{"name":" Peking University Team for the International Genetic Engineering Machine Competition (iGEM) Peking University Beijng 100871 China"}]},{"given":"Qianzhu","family":"Wu","sequence":"additional","affiliation":[{"name":" Peking University Team for the International Genetic Engineering Machine Competition (iGEM) Peking University Beijng 100871 China"}]},{"given":"Ao","family":"Liu","sequence":"additional","affiliation":[{"name":" Peking University Team for the International Genetic Engineering Machine Competition (iGEM) Peking University Beijng 100871 China"}]},{"given":"Yuheng","family":"Lu","sequence":"additional","affiliation":[{"name":" Peking University Team for the International Genetic Engineering Machine Competition (iGEM) Peking University Beijng 100871 China"}]},{"given":"Zhenzhen","family":"Yin","sequence":"additional","affiliation":[{"name":" Peking University Team for the International Genetic Engineering Machine Competition (iGEM) Peking University Beijng 100871 China"}]},{"given":"Yuansheng","family":"Cao","sequence":"additional","affiliation":[{"name":" Center for Quantitative Biology Peking University Beijng 100871 China"},{"name":" State Key Laboratory for Artificial Microstructures and Mesoscopic Physics School of Physics Peking University Beijing 100871 China"}]},{"given":"Weiqian","family":"Zeng","sequence":"additional","affiliation":[{"name":" Center for Quantitative Biology Peking University Beijng 100871 China"},{"name":" State Key Laboratory for Artificial Microstructures and Mesoscopic Physics School of Physics Peking University Beijing 100871 China"}]},{"given":"Qi","family":"Ouyang","sequence":"additional","affiliation":[{"name":" Center for Quantitative Biology Peking University Beijng 100871 China"},{"name":" State Key Laboratory for Artificial Microstructures and Mesoscopic Physics School of Physics Peking University Beijing 100871 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