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492 items Read more >>
1
"good work, the submission process, peer review, time from submission to publication is adequate. good editing process, good feed back, ..."
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"good work, the submission process, peer review, time from submission to publication is adequate. good editing process, good feed back, quality of the published figures and tables. No bias detected, good professionalism when dealing with the editor. Happy to consider submitting more papers in the future to the journal for consideration for possible publication. "
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Elgafy HK, Miller JD, Hashmi S, Ericksen S. Top 20 cited Spine Journal articles, 1990-2009. World J Orthop 2014; 5(3): 392-397
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"good work, the submission process, peer review, time from submission to publication is adequate. good editing process, good feed back, ..."
[Read more]
"good work, the submission process, peer review, time from submission to publication is adequate. good editing process, good feed back, quality of the published figures and tables. No bias detected, good professionalism when dealing with the editor. Happy to consider submitting more papers in the future to the journal for consideration for possible publication. "
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Elgafy H, Hamilton R, Peters N, Paull D, Hassan A. Critical care of obese patients during and after spine surgery. World J Crit Care Med 2016; 5(1): 83-88
3
"good work, the submission process, peer review, time from submission to publication is adequate. good editing process, good feed back, ..."
[Read more]
"good work, the submission process, peer review, time from submission to publication is adequate. good editing process, good feed back, quality of the published figures and tables. No bias detected, good professionalism when dealing with the editor. Happy to consider submitting more papers in the future to the journal for consideration for possible publication. "
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Elgafy H, Liu X, Herron J. Spinal gout: A review with case illustration. World J Orthop 2016; 7(11): 766-775
4
"good work, the submission process, peer review, time from submission to publication is adequate. good editing process, good feed back, ..."
[Read more]
"good work, the submission process, peer review, time from submission to publication is adequate. good editing process, good feed back, quality of the published figures and tables. No bias detected, good professionalism when dealing with the editor. Happy to consider submitting more papers in the future to the journal for consideration for possible publication. "
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Elgafy H, Khan M, Azurdia J, Peters N. Open wound management of esophagocutaneous fistula in unstable cervical spine after corpectomy and multilevel laminectomy: A case report and review of the literature. World J Orthop 2017; 8(8): 651-655
5
"good work, the submission process, peer review, time from submission to publication is adequate. good editing process, good feed back, ..."
[Read more]
"good work, the submission process, peer review, time from submission to publication is adequate. good editing process, good feed back, quality of the published figures and tables. No bias detected, good professionalism when dealing with the editor. Happy to consider submitting more papers in the future to the journal for consideration for possible publication. "
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Elgafy H, Raberding CJ, Mooney ML, Andrews KA, Duggan JM. Analysis of a ten step protocol to decrease postoperative spinal wound infections. World J Orthop 2018; 9(11): 271-284
6
"I am highly grateful to your journal for accepting and publishing my paper. The editorial process was meticulous and efficient, with ..."
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"I am highly grateful to your journal for accepting and publishing my paper. The editorial process was meticulous and efficient, with clear communication at every stage. The peer reviewers demonstrated profound expertise, providing constructive and detailed feedback that significantly enhanced the quality of my work. The journal's commitment to academic rigor and high publication standards is commendable. It is a leading platform in the field, facilitating the dissemination of excellent research and promoting academic progress. I look forward to future contributions to this esteemed journal. "
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Wu PH, Ta ZQ. Clinical effect and prognosis of laparoscopic surgery on colon cancer complicated with intestinal obstruction patients. World J Gastrointest Surg 2025; 17(3): 101609
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"I am very grateful to the editor and the magazine for publishing my research. The review of the manuscript is very professional, and ..."
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"I am very grateful to the editor and the magazine for publishing my research. The review of the manuscript is very professional, and the whole process is standardized and rapid. I sincerely wish that the magazine will get better and better, and the impact factor will get higher and higher. "
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Xu W, Xiong MY, Wang Y, Yu QF, Ye XJ, Wang SL, Li ZK. Role of WARP sequence magnetic resonance imaging with the removal of metal artifacts in the evaluation of lumbar adjacent. World J Orthop 2025; 16(3): 103169
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"The publication process time has generally been efficient, and the overall timeline has been reasonable. However, I have found that ..."
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"The publication process time has generally been efficient, and the overall timeline has been reasonable. However, I have found that the peer review process is quite slow, which has significantly delayed the progress of my manuscript. A faster review process would help improve the overall experience and expedite publication. Overall, I am happy to publish with this journal and appreciate the opportunity to contribute. "
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Yousif Mohamed AM, Salih M, Mohamed M, Abbas AE, Elsiddig M, Abdelsalam M, Elhag B, Mohamed N, Ahmed S, Omar D, Ahmed S, Mohamed D. Functional outcomes of peroneus longus tendon autograft for posterior cruciate ligament reconstruction: A meta-analysis. World J Orthop 2025; 16(3): 101841
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"On behalf of all authors, I'd like to congratulate the Journal for the whole process of submission and the valuable comments of the ..."
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"On behalf of all authors, I'd like to congratulate the Journal for the whole process of submission and the valuable comments of the Editor and Reviewers. The time spent for peer review was relatively short and there were no issues regarding manuscript preparation and editing. Furthermore, the communication between authors and journal was excellent as Editor responded very quickly in any requirement during submission and publication. Finally, the appearance of the article was in accordance with the Academic reputation of the journal. "
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Tosounidis T, Manouras L, Chalidis B. Osteosarcopenia and geriatric hip fractures: Current concepts. World J Orthop 2025; 16(3): 102930
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"World Journal of Orthopedics is a leading international journal in orthopedics, publishing high-quality research and reviews across ..."
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"World Journal of Orthopedics is a leading international journal in orthopedics, publishing high-quality research and reviews across joint replacement, sports medicine, and trauma. With a rigorous peer-review process and open-access model, it ensures broad dissemination of impactful studies. Its commitment to advancing orthopedic science and practice makes it an essential resource for researchers and clinicians worldwide. "
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Wang YC, Cheng JB, Feng ML. Requirements for standardizing the assessment of mesenchymal stem cell therapy and its effects on osteoarthritis. World J Orthop 2025; 16(3): 104451
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"We would like to thank all the reviewers and editors for their hard work on this manuscript. The comments of the peer reviewers were ..."
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"We would like to thank all the reviewers and editors for their hard work on this manuscript. The comments of the peer reviewers were relevant and objective. They have highlighted the strengths of the study while pointing out the limitations and the areas needed to be revised and improved. We have addressed all comments of the peer reviewers in the revised manuscript. The editorial team demonstrates meticulous attention to detail, ensuring that every manuscript undergoes a thorough and professional review process. They were very patient during the editing process of this article. We wish the journal continues to achieve more success and to make greater contributions to medical science. "
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Liu M, Ji YL, Hu YJ, Su YX, Yang J, Wang XY, Chu HY, Zhang X, Dong SJ, Yang H, Liu YH, Zhou SM, Guo LP, Ran Y, Li YN, Zhao JW, Zhang ZG, Piao MY, Zhou L. Lactococcus garvieae aggravates cholestatic liver disease by increasing intestinal permeability and enhancing bile acid reabsorption. World J Gastroenterol 2025; 31(10): 101014
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Zhu K, Zhang ZX, Zhang M. Application value of machine learning models in predicting intraoperative hypothermia in laparoscopic surgery for polytrauma patients. World J Clin Cases 2024; 12(24): 5513-5522
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"I also found the immediate assistance provided by the Assistant Editors to be good in resolving issues during submission. It will ..."
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"I also found the immediate assistance provided by the Assistant Editors to be good in resolving issues during submission. It will certainly be a Journal destined to grow both in terms of the number and quality of its publications. I will definitely take it into consideration for submitting other manuscripts and therefore publishing future articles. "
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Casu C, Inchingolo AM, Orrù G. Interleukin 10 supplement to reduce episodes of recurrent aphthous stomatitis. World J Methodol 2025; 15(3): 99176
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"I’m truly impressed by their rigorous yet efficient peer-review process—the feedback from experts was both critical and constructive, ..."
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"I’m truly impressed by their rigorous yet efficient peer-review process—the feedback from experts was both critical and constructive, directly enhancing the clarity and impact of my work. What’s equally commendable is the editorial team’s dedication to detail. During proofreading, they meticulously addressed formatting inconsistencies and even suggested nuanced language improvements, ensuring the final version was polished. Communication was consistently prompt and professional, which made the entire submission-to-publication journey surprisingly smooth. "
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Li J, Ma LJ, Ma XY, Gao B. Relationship between weight-to-waist index and post-stroke depression. World J Psychiatry 2025; 15(3): 100909
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"I am Satisfied with he online submission system、the peer review report、online submission system、 the article PDFs、period of ..."
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"I am Satisfied with he online submission system、the peer review report、online submission system、 the article PDFs、period of publication、editing quality of the article、the requirement for providing academic rules and norms、the academic misconduct detection report、published articles processes.、anonymous peer review process ... I will continue to contribute if there are relevant articles. Thank you. "
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Liu X, Wang YF, Qi XH, Zhang ZL, Pan JY, Fan XL, Du Y, Zhai YM, Wang Q. Reproducibility study of intravoxel incoherent motion and apparent diffusion coefficient parameters in normal pancreas. World J Gastrointest Surg 2024; 16(7): 2031-2039
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"Dear WJT, the authors are satisfied with the convenience and support provided by the journal during the submission process. We would ..."
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"Dear WJT, the authors are satisfied with the convenience and support provided by the journal during the submission process. We would also like to thank you for all the comments that helped to improve our text. Since the peer review process, we have found elements that have substantially polished the text. The submission platform was also very practical, facilitating communication between authors and editors. Leonardo Kasputis Zanini "
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Kasputis Zanini LY, Lima FR, Fernandes MR, Alvarez PSE, Silva MS, Martins Filho APR, Franzini TAP, Nacif LS. Ischemic colitis with small-vessel occlusion, simultaneous total colectomy and liver transplantation: A case report. World J Transplant 2025; 15(2): 98620
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"The peer reviewers were experts in the subject area of this manuscript. They have reviewed the whole manuscript. Peer review time ..."
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"The peer reviewers were experts in the subject area of this manuscript. They have reviewed the whole manuscript. Peer review time was satisfactory. The comments of the peer reviewers were relevant and objective. They have highlighted the strengths of the study while pointing out the limitations and the areas needed to be revised, changed and improved. The comments helped improved the manuscript significantly. We have addressed all comments of the peer reviewers in the revised manuscript. I appreciate the valuable comments which helped up lift the scientific quality of the article. "
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Wickramasinghe N, Devanarayana NM. Insight into global burden of gastroesophageal reflux disease: Understanding its reach and impact. World J Gastrointest Pharmacol Ther 2025; 16(1): 97918
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"For your journal's treatment of all aspects, there is no opinion at present, I am very satisfied, and the opinions put forward by ..."
[Read more]
"For your journal's treatment of all aspects, there is no opinion at present, I am very satisfied, and the opinions put forward by the experts are also very professional, which is of great benefit to the article, and I look forward to submitting the manuscript again next time, thank you very much! "
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Yang Y, Chen Y, Tang JY, Chen J, Li GQ, Feng B, Mu J. MiR-29a-3p inhibits fibrosis of diabetic kidney disease in diabetic mice via downregulation of DNA methyl transferase 3A and 3B. World J Diabetes 2025; 16(4): 93630
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Zhu LL, Shen RZ. Follow-up of elderly gastric cancer post-radical surgery: Trauma, complications, and prognosis. World J Gastrointest Surg 2025; 17(3): 100143
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"Thenk you very much for the oppotunity to share my opinion. Draws attention lack of readity available information on the journal's ..."
[Read more]
"Thenk you very much for the oppotunity to share my opinion. Draws attention lack of readity available information on the journal's website, but required checklists. Additionally paid certificate for notnative even though the article was checked by nativ. after being checked by a certified company, only minor corrections were noted. "
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Wójcik-Niklewska B, Filipek E. Luscan-Lumish syndrome: A case report. World J Clin Cases 2025; 13(18): 101471
18267 items Read more >>
1
"Assessment of the Article
1. Ethics
The article does not provide an explicit ethical approval form, which is understandable as it ..."
[Read more]
"Assessment of the Article
1. Ethics
The article does not provide an explicit ethical approval form, which is understandable as it is a mini-review rather than an empirical study involving human or animal subjects.
2. Methods
As a review article, the methods section focuses on the methodology of data collection rather than experimental procedures. The authors conducted a comprehensive search of peer-reviewed articles and preclinical studies using PubMed, Scopus, and Web of Science databases, with clear inclusion criteria. The methods used to collect and analyze the data are well-described and can be repeated by fellow researchers. The references provided offer adequate textual/citation content to support the findings.
3. Results
The results presented in the article are based on the findings of previously published studies. While the authors do not present new empirical data, they synthesize and interpret existing research to draw conclusions about the therapeutic potential of elafibranor in alcohol-associated liver disease. The theories and hypotheses discussed are partially validated by the cited preclinical and clinical studies. The results are true and authentic to the extent that they accurately reflect the current state of knowledge in the field.
4. Figures and Tables
The article contains one figure and one table that effectively illustrate the key mechanisms of elafibranor's action in alcohol-associated liver disease. The figure is well-constructed, annotated, and easy to understand. The table provides a concise summary of elafibranor's mechanisms and their benefits in ALD, which enhances the readability and comprehensibility of the review.
5. Biostatistics
As a review article, the focus is on the synthesis and interpretation of existing research rather than the presentation of new biostatistical data. The authors do not provide tables or line charts with biostatistical data. Instead, they discuss the results of previous studies and their implications for elafibranor's therapeutic potential.
6. References
The authors scientifically and reasonably cite the latest references in the field of alcohol-associated liver disease and related scientific problems. The references cover a wide range of topics, including the pathogenesis of ALD, the role of macrophages, and the preclinical and clinical studies of elafibranor. The authors do not appear to self-cite, omit, mis-cite, or over-cite references.
7. Language
The language in the article is clear, concise, and accurate. The information is presented in a logical and well-organized manner. The article does not contain multiple grammatical or spelling mistakes, which enhances its readability and credibility.
8. Caveats or Drawbacks
While the article provides a comprehensive review of elafibranor's therapeutic potential in ALD, it is important to note that the majority of the evidence is based on preclinical studies. Clinical trials are ongoing, and the long-term safety and efficacy of elafibranor in humans remain to be established. Additionally, the heterogeneity of ALD patients and the complexity of the disease pathogenesis may limit the generalizability of the findings. These caveats should be considered when interpreting the results of the review.
"
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Farhadi S, Mohammadi S, AlKindi AY, Al-Amri IS. Therapeutic potential of elafibranor in alcohol-associated liver disease: Insights into macrophage modulation and fibrosis reduction. World J Biol Chem 2025; 16(1): 104535
2
"This article explores the development of both 2D and 3D osteogenic coculture models to investigate the dynamic interactions between ..."
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"This article explores the development of both 2D and 3D osteogenic coculture models to investigate the dynamic interactions between macrophages and ADSCs. It highlights possible mechanisms governing osteogenesis and immune modulation, offering valuable insights into bone tissue engineering and regenerative medicine. However, integrating novel and advanced methodologies, along with the potential for futuristic in vivo translation and a critical evaluation of existing limitations, could further clarify the significance of the findings."
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Zhang HA, Zhang BY, Tang HB. Effects of macrophages on the osteogenic differentiation of adipose tissue-derived stem cells in two-dimensional and three-dimensional cocultures. World J Stem Cells 2025; 17(2): 99326
3
"It is a well-designed study that presents evidence for WDR36’s inhibitory role in the osteogenic differentiation and migration of ..."
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"It is a well-designed study that presents evidence for WDR36’s inhibitory role in the osteogenic differentiation and migration of PDLSCs. The microscopic images are of good quality and effectively illustrate the findings. However, improving the quality of western blots and providing stronger quantification would further enhance the impact and readability of the manuscript "
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Wang Y, Zhang FQ, Fan ZP, Zhu XL, Yan WH, Zhang XL. WDR36 inhibits the osteogenic differentiation and migration of periodontal ligament stem cells. World J Stem Cells 2025; 17(2): 99132
4
"It is a good review with high-quality illustrations. This article describes various stem cell-based and exosome-based therapeutic ..."
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"It is a good review with high-quality illustrations. This article describes various stem cell-based and exosome-based therapeutic possibilities for skeletal muscle atrophy, highlighting their potential in regeneration and functional recovery. The comprehensive insights into emerging strategies make it a valuable resource for advancing regenerative medicine approaches in muscle disorders. However, the concluding remarks on the superiority of stem cell therapy over other treatment options remain open for further exploration."
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Wang YJ, Chen ZH, Shen YT, Wang KX, Han YM, Zhang C, Yang XM, Chen BQ. Stem cell therapy: A promising therapeutic approach for skeletal muscle atrophy. World J Stem Cells 2025; 17(2): 98693
5
"It is a good article, highlighting the use of NAD⁺ to boost the viability of BM-MSCs, offering a promising therapeutic strategy for ..."
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"It is a good article, highlighting the use of NAD⁺ to boost the viability of BM-MSCs, offering a promising therapeutic strategy for regenerative medicine and immune modulation. As this study primarily relies on in vitro models, the cost and affordability of MSC treatments, along with other cost-effective alternatives, raise important considerations for widespread clinical application."
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Xia X, Zhou K, An LY, Zhao M, Tian BL, Zhao JY, Zhou ZG, Tong Y. Nicotinamide adenine dinucleotide rejuvenates septic bone marrow mesenchymal stem cells. World J Stem Cells 2025; 17(2): 96893
6
"This article reviewed the advances in the diagnosis and management of
coronary microvascular dysfunction focusing on the patients ..."
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"This article reviewed the advances in the diagnosis and management of
coronary microvascular dysfunction focusing on the patients who underwent PCI.
I think the following two explanation could be added for this excellent review article.
The authors admirably discussed the pathophysiology and metabolic risk interactions.
However, the authors did not refer the (epicardial) coronary artery spasm as one of the causes of post PCI myocardial ischemia. I think epicardial coronary spasm is often associated with epicardial coronary stenosis which is physiologically significant. In these patients, chest pain occurs often even after PCI even if there is no coronary microvascular dysfunction.
Coronary microvascular dysfunction might be classified into two groups. One group is recognized also before PCI, and the other occurred only after PCI in cases such as acute coronary syndrome (no reflow phenomenon).
"
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Tang N, Li KM, Li HR, Zhang QD, Hao J, Qi CM. Advances in the diagnosis and management of post-percutaneous coronary intervention coronary microvascular dysfunction: Insights into pathophysiology and metabolic risk interactions. World J Cardiol 2025; 17(2): 103950
7
"Indeed, TIPS is an interventional radiological procedure that significantly reduces portal pressure, prevents decompensation and ..."
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"Indeed, TIPS is an interventional radiological procedure that significantly reduces portal pressure, prevents decompensation and improves survival of cirrhotic patients. The authors provided interesting but very limited information about the TIPS as a method for the treatment of portal hypertension complications. For example, the main TIPS-related problems, namely shunt dysfunction and post-TIPS hepatic encephalopathy, have not been considered at all."
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de Mattos AA, de Mattos AZ, Manica M, Tovo CV. Which patients benefit the most? An update on transjugular intrahepatic portosystemic shunt. World J Hepatol 2025; 17(2): 99809
8
"1. Ethics:
The ethical approval for this study is mentioned as granted by the Ethics Committee of Xuzhou Central Hospital.
2. ..."
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"1. Ethics:
The ethical approval for this study is mentioned as granted by the Ethics Committee of Xuzhou Central Hospital.
2. Methods:
The study is a retrospective comparative study analyzing 123 patients treated with either microwave ablation (MWA) or laparoscopic hepatectomy (LH). The inclusion and exclusion criteria are clearly outlined. The treatment protocols for both procedures are well described, making it possible for other researchers to replicate the methods.
3. Results:
The results indicate that MWA has advantages over LH, with shorter operative time, lower intraoperative bleeding, and faster recovery. The study shows statistically significant differences in postoperative complications (4.84% in the MWA group vs. 19.67% in the LH group, P = 0.012). The effective rate of treatment was also significantly higher in the MWA group (P = 0.027).
However, long-term survival outcomes such as recurrence-free survival (RFS) or overall survival (OS) are expected.
4. Figures and Tables:
The manuscript contains clear tables and well-labeled figures comparing perioperative indicators and postoperative outcomes. Data is systematically structured, and statistical significance is appropriately indicated (P values provided).
5. Biostatistics:
The study employs basic statistical methods (t-test, χ² test) to compare continuous and categorical variables. The analysis appears appropriate, but there are no multivariate analyses to control for confounders, which is a limitation.
6. References:
The references include recent and relevant studies, particularly those from Nature Reviews Gastroenterology & Hepatology, Hepatology, and World Journal of Gastrointestinal Surgery.
7. Language and Clarity:
The manuscript is written in clear and professional English, with minimal grammatical errors. However, some sentences are redundant or could be more concise, particularly in the discussion.
The study provides valuable short-term comparative data on MWA vs. LH for primary small liver cancer. However, the lack of long-term follow-up and absence of multivariate analysis limits the strength of its conclusions. The authors should be encouraged to include propensity score matching, long-term survival data, and quality-of-life outcomes in future studies."
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Li HS, Zhang XF, Fu J, Yuan B. Efficacy of microwave ablation vs laparoscopic hepatectomy for primary small liver cancer: A comparative study. World J Gastrointest Surg 2025; 17(3): 101786
9
"1. Ethics
The ethical approval process is clearly documented.
2. Methods
The case report aligns with typical diagnostic and ..."
[Read more]
"1. Ethics
The ethical approval process is clearly documented.
2. Methods
The case report aligns with typical diagnostic and therapeutic workflows for CHD and PE. However, methodological details could be improved further (e.g., specific criteria for selecting CABG over other interventions, anticoagulant dosing protocols).
3. Results
Results are consistent with clinical findings (elevated D-dimer, CTPA-confirmed PE, CAG-confirmed CHD).
Limitation: No long-term follow-up data beyond 2 months.
4. Figures and Tables
Figures clearly demonstrate the patient’s progression and treatment response.
5. Biostatistics
Not applicable to this case report, as no statistical analysis was performed.
6. References
Citations include key guidelines and recent studies. References support the discussion of overlapping CHD/PE symptoms and treatment strategies.
7. Language
The language is generally clear and professional.
8. Caveats or Drawbacks
Relative sShort follow-up period."
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Xu JQ, Jiang MX, Wang F, Yang KQ, Xu YJ, Wang YJ, Dong SJ. Coronary heart disease with pulmonary embolism: A case report. World J Cardiol 2025; 17(2): 101588
10
"The topic is of great interest. Assessment of VOCs is novel, non-ivasive approach to diagnose cardiovascular disease such as ischemic ..."
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"The topic is of great interest. Assessment of VOCs is novel, non-ivasive approach to diagnose cardiovascular disease such as ischemic heart disease and heart failure. It is also important to help secandary prevention of such diseases. However we need some more data and advanced technologies for assessement of VOCs. In this perspective, thie review is worth reading. "
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Marzoog BA, Chomakhidze P, Gognieva D, Parunova AY, Demchuk SN, Silantyev A, Kuznetsova N, Kostikova A, Podgalo D, Nagornov E, Gadzhiakhmedova A, Kopylov P. Updates in breathomics behavior in ischemic heart disease and heart failure, mass-spectrometry. World J Cardiol 2025; 17(2): 102851
11
"The authors reported substantial findings regarding novel predictibe biomarler for ACS based on the calculation of RBC width to albumin ..."
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"The authors reported substantial findings regarding novel predictibe biomarler for ACS based on the calculation of RBC width to albumin ratio. The aim of the study is clear and the paper is well written. The manuscript has high relevance and adequacy of the literature presented, including recognition of gaps in knowledge, interpretation of findings and significance of other recent research on the topic, and readable conclusion. The findings are based on the relevant statistics, while the weaknes of the study was a retrospective design. However, the authors obtained promising results which are likely to be implemented in clinical practice without sufficient economic expenditure. Overall, the article scientifically sounds and contributes to the reader attractivity. I congratulate the authors on the study."
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Wang JN, Hu ZS, Yu YW, Peng XH. Red blood cell distribution width to albumin ratio is correlated with prognosis of patients in coronary care unit. World J Cardiol 2025; 17(2): 103273
12
"• Echinococcosis is a parasitic disease caused by tapeworms of the genus Echinococcus. It can be transmitted to humans from animals, ..."
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"• Echinococcosis is a parasitic disease caused by tapeworms of the genus Echinococcus. It can be transmitted to humans from animals, making it a zoonotic disease. Treatment options include surgery, albendazole, and PAIR (puncture, aspiration, injection, re-aspiration).Please comment about PAIR. The diagnosis of echinococcosis relies mainly on findings by ultrasonography and/or other imaging techniques supported by positive serologic test. I ask you .
What kinds of examination do you performed for seronegative patients with hepatic image findings compatible with echinococcosis。
"
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Pavlidis ET, Galanis IN, Pavlidis TE. Current considerations for the management of liver echinococcosis. World J Gastroenterol 2025; 31(10): 103973
13
"The article discusses a novel approach to diagnosing fistula-in-ano using high-resolution hydrogen peroxide-enhanced magnetic resonance ..."
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"The article discusses a novel approach to diagnosing fistula-in-ano using high-resolution hydrogen peroxide-enhanced magnetic resonance imaging (HPMRI) fistulography. Fistula-in-ano, a chronic infection affecting the perianal region, can be caused by several factors like Crohn's disease, pelvic infections, or radiotherapy. It is more common in younger adults and often presents with symptoms such as discharge and localized pain. This study sought to compare the effectiveness of various diagnostic techniques for detecting internal openings, fistula tracks, and perianal abscesses in patients undergoing surgery.
The study included 60 patients and compared methods such as physical examination, ultrasound, low-resolution MRI, and high-resolution HPMRI. The results showed that high-resolution HPMRI had the highest sensitivity and specificity for detecting these features, particularly for complex and recurrent fistulas, with Kappa values indicating almost perfect agreement between observers. Furthermore, HPMRI outperformed the other methods in terms of diagnostic accuracy, with improved image quality achieved through optimized MRI protocols and contrast agents.
The study emphasizes the importance of HPMRI for preoperative assessment, especially in complex cases where other methods like ultrasound or low-resolution MRI may fall short. The high spatial resolution provided by HPMRI allowed for clearer visualization of fistula tracks and internal openings, which is crucial for accurate surgical planning and reducing recurrence rates."
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Chang CC, Qiao LH, Zhang ZQ, Tian X, Zhang Y, Cheng WW, Wang X, Yang Q. High-resolution direct magnetic resonance imaging fistulography with hydrogen peroxide for diagnosing anorectal fistula: A preliminary retrospective study. World J Radiol 2025; 17(1): 101221
14
"Oral and maxillofacial diagnostic imaging plays a crucial role in dental diagnosis, treatment planning, and follow-up procedures. ..."
[Read more]
"Oral and maxillofacial diagnostic imaging plays a crucial role in dental diagnosis, treatment planning, and follow-up procedures. X-rays, particularly intraoral periapical radiography, have been the primary imaging technique in clinical dental practice since their introduction in the early 20th century. Over time, several advanced imaging technologies have emerged, enhancing the diagnostic capabilities of dentists. Among these are various types of digital sensors, such as charge-coupled devices and complementary metal oxide semiconductors, which allow for clearer, more detailed images. However, issues like patient discomfort during imaging and positioning errors still pose challenges, affecting the quality of images.
Periapical radiographs are vital for visualizing the entire crown and root of teeth, providing essential information for diagnosing common dental issues like periodontal and periapical diseases. Bite-wing radiographs, which focus on interproximal surfaces, are also used for detecting caries, periodontal disease, and restorations. While these 2D imaging techniques are useful, they have limitations in showing more complex anatomical structures and pathologies.
Panoramic radiography, another common method, provides broader images by rotating the X-ray source and detector around a stationary patient. This method, though effective for evaluating both jaws, suffers from issues like unequal magnification and image distortion. Cone beam CT (CBCT), which offers three-dimensional images of the dentomaxillofacial region, is a significant advancement. It provides detailed information on complex structures and is especially useful in fields like implantology, orthodontics, and maxillofacial surgery. While CBCT offers advantages over traditional X-rays, it does have limitations in soft tissue contrast.
Micro-CT, which provides extremely detailed 3D images, is another emerging tool, primarily for research purposes. It offers high resolution for assessing tooth and bone structures but is not yet feasible for routine clinical use due to its high radiation doses and costs. Ultrasonography (US) is a non-invasive alternative that doesn’t use ionizing radiation. It’s especially useful for examining superficial soft tissues, bone, and conditions like salivary gland lesions. However, it has limitations in visualizing deeper tissues like bone.
Magnetic resonance imaging (MRI), another ionizing-free method, offers excellent soft tissue contrast and is becoming increasingly important for assessing temporomandibular joint (TMJ) disorders and soft tissue lesions. MRI can also be used for evaluating bone loss and inflammation. Recently, MRI technology tailored specifically for dental applications has shown promise in providing detailed views of dentomaxillofacial structures.
The advent of 3D printing technology in dentistry is revolutionizing how dental procedures are planned and executed. With the help of CBCT data, 3D-printed models can be used for creating precise surgical guides, which are particularly beneficial in implantology. This technology is also being explored in fields like endodontics, periapical surgery, and maxillofacial surgery, and has the potential to improve procedural accuracy and efficiency.
Artificial intelligence (AI) is another exciting development in dental imaging. AI algorithms are being explored for tasks like disease detection, image segmentation, and treatment planning, with the potential to enhance diagnostic accuracy and efficiency. However, while AI has shown promise, it is still in the research phase and needs further validation before it can be fully integrated into clinical practice.
In conclusion, advancements in dental imaging technologies, such as CBCT, 3D printing, and AI, are significantly improving the diagnostic and treatment capabilities in dentistry. These innovations are expected to enhance clinical outcomes, reduce diagnostic errors, and increase efficiency. However, challenges like high costs, long scanning times, and the need for further research in AI remain. Continued exploration of these technologies will contribute to the evolution of dental care, offering new possibilities for diagnosis and treatment."
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Kamburoğlu K. Trends in dentomaxillofacial radiology. World J Radiol 2025; 17(1): 97255
15
"The article compares whole-body MRI (wbMRI) with PET/CT for staging diffuse large B-cell lymphoma (DLBCL), and provides important ..."
[Read more]
"The article compares whole-body MRI (wbMRI) with PET/CT for staging diffuse large B-cell lymphoma (DLBCL), and provides important insights into the potential of wbMRI as an alternative imaging modality. The study aims to evaluate the diagnostic effectiveness of both techniques in a clinical setting, using key metrics like sensitivity, specificity, and accuracy. The authors present a clear hypothesis, a solid methodological framework, and appropriate statistical analyses, which establish the credibility and reliability of the results.
Despite the article’s strengths, a few issues remain that could limit its objectivity and the generalizability of the findings. One key concern is the small sample size, with only 14 patients included in the study. This raises questions about the representativeness of the sample and the external validity of the conclusions. A larger and more diverse cohort could provide more robust and widely applicable results. Additionally, the study focuses primarily on the diagnostic accuracy of wbMRI but does not delve deeply into the practical implications of implementing this modality in clinical practice. Issues like the potential for longer scan times and the lack of functional data, which PET/CT provides, are not sufficiently addressed. These factors may limit the clinical utility of wbMRI, and it would be valuable for future research to explore solutions to these limitations, such as combining wbMRI with other imaging techniques to provide more comprehensive results.
The ethical approval and informed consent procedures are clearly outlined, contributing to the study’s scientific credibility. The authors also conduct appropriate statistical analyses, and the findings are statistically significant. However, the article could benefit from a more thorough examination of the real-world impact of incorporating wbMRI into routine DLBCL staging. For example, cost-effectiveness, patient comfort, and potential integration into clinical workflows were not explored in depth. These aspects are important for assessing the practical feasibility of adopting wbMRI more broadly. Furthermore, while the authors discuss the diagnostic performance of wbMRI, they do not fully consider the limitations of this imaging modality, such as longer scan times and the absence of functional data, which are key features of PET/CT.
In terms of future directions, the study would benefit from larger-scale research involving more diverse patient populations. Additionally, hybrid imaging techniques, which combine the strengths of both wbMRI and functional imaging methods like PET/CT, could offer a promising avenue to enhance diagnostic accuracy. Addressing patient comfort, particularly by reducing scan duration, and incorporating cost-effectiveness analyses into future studies would further improve the practical applicability of wbMRI. By addressing these issues, future research could provide more comprehensive, clinically relevant findings that would further strengthen the case for wbMRI as a viable alternative to PET/CT in lymphoma staging.
In conclusion, while the article contributes valuable insights into the potential of wbMRI in DLBCL staging, several issues remain unresolved. These include the small sample size, practical challenges related to patient comfort, and the limitations of wbMRI compared to PET/CT. By addressing these concerns in future studies, the authors could enhance the scientific quality and applicability of their research, ultimately contributing to the development of better diagnostic tools for lymphoma management."
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Lambert L, Wagnerova M, Vodicka P, Benesova K, Zogala D, Trneny M, Burgetova A. Whole-body magnetic resonance imaging provides accurate staging of diffuse large B-cell lymphoma, but is less preferred by patients. World J Radiol 2025; 17(1): 99207
16
"The article "Retrospective analysis of delta hemoglobin and bleeding-related risk factors in pancreaticoduodenectomy" presents a ..."
[Read more]
"The article "Retrospective analysis of delta hemoglobin and bleeding-related risk factors in pancreaticoduodenectomy" presents a well-structured and objective study with clear methodology and robust statistical analysis. The authors effectively address the limitations of visual estimation of intraoperative blood loss by introducing delta hemoglobin (ΔHb) as a more objective metric. The study's credibility is reinforced by its large sample size (n=1722) and the rigorous statistical evaluation, including univariate and multivariate regression analyses to identify independent bleeding risk factors.
Key issues resolved include demonstrating a significant correlation between ΔHb and estimated blood loss (EBL), as well as identifying ASA classification IV, BMI > 24 kg/m², and preoperative total bilirubin > 200 μmol/L as independent risk factors for perioperative bleeding. However, some limitations persist, such as potential biases from a single-center retrospective design and confounding factors like fluid resuscitation affecting ΔHb values.
Future research should focus on multicenter validation and prospective studies to confirm ΔHb’s predictive value across different institutions. Additionally, exploring real-time ΔHb monitoring and integrating machine learning models for individualized bleeding risk prediction could enhance clinical applicability. This study provides valuable insights that contribute to surgical safety and perioperative risk stratification."
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Lin YM, Yu C, Xian GZ. Retrospective analysis of delta hemoglobin and bleeding-related risk factors in pancreaticoduodenectomy. World J Gastrointest Surg 2025; 17(3): 100999
17
"The study aimed to evaluate the efficacy of ASC-Exos cross-linked CS-αβ-GP hydrogel on treating deep burn wounds. Some papers have ..."
[Read more]
"The study aimed to evaluate the efficacy of ASC-Exos cross-linked CS-αβ-GP hydrogel on treating deep burn wounds. Some papers have demostrated exosomal effects on skin wound like burning wound, however the selection of scaffold for the exosomal treatment has been still challenging. In the paper, the author used chitosan (CS)-αβ-glycerophosphate (CS-αβ-GP) hydrogel as a scaffold and that was cross-linked with adipose-derived stem cell exosomes (ASC-Exos). In results, they showed impactful anti-inflammatory effects, promotes wound healing, and facilitates the transition of M1 macrophages to M2 macrophages by blocking the NF-κB pathway. From the study, we can get an insight for using CS-αβ-GP as a scaffold for exosomal treatment."
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Xu L, Liu D, Yun HL, Zhang W, Ren L, Li WW, Han C. Effect of adipose-derived stem cells exosomes cross-linked chitosan-αβ-glycerophosphate thermosensitive hydrogel on deep burn wounds. World J Stem Cells 2025; 17(2): 102091
18
"This manuscript presents a letter to the editor, providing commentary on a study addressing gallbladder cancer, a rare malignancy ..."
[Read more]
"This manuscript presents a letter to the editor, providing commentary on a study addressing gallbladder cancer, a rare malignancy associated with high morbidity. The primary study resulted in the development of a nomogram, which serves as a valuable tool for guiding multimodality therapy and evaluating prognosis. The manuscript demonstrates a well-structured and balanced approach to its subject matter."
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Mayer NR, Ehrenpreis ED. Modeling post-operative survival in patients with gallbladder cancer resections: The road to improved patient care? World J Gastrointest Surg 2025; 17(2): 101553
19
"Good study with potential expected impact on further studies. It helps in prediction of new-onset
diabetes in middle-aged and older ..."
[Read more]
"Good study with potential expected impact on further studies. It helps in prediction of new-onset
diabetes in middle-aged and older population and its association with depression. Though it is mentioned clearly that the new-onset diabetes was not a direct complication of depression, but rather that depressive states led to behaviors that increased the risk of being overweight and then increase probability of new-onset diabetes. It is suggested to establish hormonal imbalance and chemical suggestions in this regard to prove the facts."
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Zhang ZH, Yue SY, Su M, Zhang HL, Wu QC, Li ZL, Zhang NJ, Hao ZY, Li M, Huang HJ, Ma J, Liu YY, Wang H. Overweight in mediating the association between depression and new-onset diabetes: A population-based research from Health and Retirement Study. World J Diabetes 2025; 16(3): 100245
20
"This is very interesting paper. Local administration of mesenchymal stem cells or their derived extracellular vesicles has emerged ..."
[Read more]
"This is very interesting paper. Local administration of mesenchymal stem cells or their derived extracellular vesicles has emerged as a promising therapeutic strategy through suppression of the inflammatory cells and promotion of fistula healing in PFCD. Please tell me the indication of Local administration of mesenchymal stem cells or their derived extracellular vesicles for PFCD."
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Bhatnagar P, Elhariri S, Burud IAS, Eid N. Perianal fistulizing Crohn’s disease: Mechanisms and treatment options focusing on cellular therapy. World J Gastroenterol 2025; 31(9): 100221
15128 items Read more >>
Peer-Reviewers and Manuscript Statistics
- Editorial board members
- 2267
- Peer-reviewers
- 29234
- Manuscripts received today
- 7
- Manuscript reviews today
- 12
- Unhandled manuscripts today
- 151
- Active peer-reviewers today
- 2089
- Reviewer acceptance today
- 30
- Reviewer refusals today
- 57
- Total accepted manuscripts
- 35233
- Total rejected manuscripts
- 40752
- Total peer-reviewers
- 4085348
- Total submissions
- 33509
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1
"This study provides valuable data specifically focused on endoscopic resection (ER) of esophageal GISTs. Thorough evaluation of the ..."
[Read more]
"This study provides valuable data specifically focused on endoscopic resection (ER) of esophageal GISTs. Thorough evaluation of the ER technique, complications, and resection margin status enhances our understanding of ER safety and effectiveness. Furthermore, the study presented a relatively large case series of 32 patients, which increases the statistical reliability of the findings for esophageal GIST research. By presenting long-term follow-up results, it assessed the long-term prognosis after ER and suggested potential benefits for future treatment strategy development. "
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Xu EP, Qi ZP, Zhang JW, Li B, Ren Z, Cai MY, Cai SL, Lv ZT, Chen ZH, Liu JY, Zhong YS, Zhou PH, Shi Q. Endoscopic treatment outcome of oesophageal gastrointestinal stromal tumours. World J Gastroenterol 2025; 31(10): 102393
2
"We greatly appreciate the authors and their team for their in-depth study on treatment strategies for rectal neuroendocrine neoplasms ..."
[Read more]
"We greatly appreciate the authors and their team for their in-depth study on treatment strategies for rectal neuroendocrine neoplasms (R-NENs). This retrospective analysis compares the efficacy of endoscopic full-thickness resection (EFTR) and endoscopic submucosal dissection (ESD) in the treatment of R-NENs, demonstrating the superior R0 resection rate of EFTR while maintaining comparable short-term safety with ESD. This study provides critical clinical evidence supporting the use of EFTR in R-NENs and contributes to the refinement of function-preserving surgical approaches. However, we would like to offer some constructive suggestions to enhance the clinical applicability and long-term evaluation of this study. First, some terminology and definitions in the study are somewhat ambiguous, which may affect the interpretability of the results. For instance, the study mentions that some patients had "severe comorbidities" but does not specify the types of comorbidities or the inclusion/exclusion criteria applied. Certain comorbidities, such as diabetes or chronic kidney disease, may impact postoperative healing, and failing to differentiate them could introduce confounding among patients with varying risk profiles. Additionally, the description of lesion morphology is inherently subjective, and the study does not clarify whether standardized imaging assessments, such as endoscopic ultrasound (EUS), were used to measure lesion size and invasion depth. Inconsistencies in preoperative evaluation criteria could lead to bias in treatment selection. For example, was EFTR preferentially chosen for lesions with specific morphological characteristics? Future studies should adopt more detailed imaging assessment criteria and pathological grading methods to improve reproducibility and the interpretability of results. Second, the study does not assess the impact of the learning curve for EFTR and ESD on surgical outcomes. As a relatively novel technique, EFTR may require a longer period of experience accumulation to achieve stable performance. The study does not clarify whether operator experience was comparable between the EFTR and ESD groups or whether surgical success rates varied with increasing experience. If EFTR procedures were performed by highly experienced endoscopists while ESD procedures involved a broader range of operators, the results could be biased in favor of EFTR. Additionally, since EFTR has a steeper learning curve, factors such as procedure time and complication rates may decrease with increased experience, but the study does not conduct a dynamic analysis of these trends. Future studies should incorporate learning curve analyses to evaluate the influence of experience on surgical outcomes, ensuring a fair comparison between the two techniques. Furthermore, EFTR may cause greater bowel wall injury than ESD, potentially affecting postoperative bowel function, yet this study focuses primarily on R0 resection rates and short-term complications without assessing long-term functional outcomes. As a full-thickness resection technique, EFTR may alter rectal compliance, bowel movement frequency, and gut motility. However, the study does not provide data on postoperative bowel function changes, alterations in defecation patterns, bloating, or incontinence. If EFTR improves R0 resection rates but increases the risk of postoperative functional impairment, its clinical utility must be considered more cautiously. Future research should incorporate patient-reported outcomes (PROs) and quality of life (QoL) assessments and include long-term functional evaluations such as anorectal manometry and bowel dysfunction scoring to comprehensively assess the impact of EFTR on patient prognosis. "
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Zhang XL, Jiang YY, Chang YY, Sun YL, Zhou Y, Wang YH, Dou XT, Guo HM, Ling TS. Endoscopic full-thickness resection: A definitive solution for local complete resection of small rectal neuroendocrine neoplasms. World J Gastroenterol 2025; 31(10): 100444
3
"This is a well-constructed and well-written review, which gives readers with a general bioscience background updated information about ..."
[Read more]
"This is a well-constructed and well-written review, which gives readers with a general bioscience background updated information about the stem cell application in liver diseases (fatty liver diseases and steatohepatitis). The language is fluent, and the references are up to date. It will be easier for readers to understand the concepts if the authors provide a table to compare the 2D model with the 3D model. It will be helpful to include the abbreviation for each key word. "
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Silva B, Bragança J. Induced pluripotent stem cell-derived mesenchymal stem cells for modeling and treating metabolic associated fatty liver disease and metabolic associated steatohepatitis: Challenges and opportunities. World J Stem Cells 2025; 17(2): 99331
4
"The authors should provide adequate legends for each figure. Some parts of the paper are just a listing of facts and are poorly ..."
[Read more]
"The authors should provide adequate legends for each figure. Some parts of the paper are just a listing of facts and are poorly organized or discussed. The table in the paper is well organized and suited. A table to compare the pros and cons of different kinds of stem cells for muscle atrophy therapy will be helpful. "
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Wang YJ, Chen ZH, Shen YT, Wang KX, Han YM, Zhang C, Yang XM, Chen BQ. Stem cell therapy: A promising therapeutic approach for skeletal muscle atrophy. World J Stem Cells 2025; 17(2): 98693
5
"Stem Cell Therapy: A New Hope for Patients with Skeletal Muscle Atrophy? Skeletal muscle atrophy refers to the reduction or loss of ..."
[Read more]
"Stem Cell Therapy: A New Hope for Patients with Skeletal Muscle Atrophy? Skeletal muscle atrophy refers to the reduction or loss of muscle fibers due to nutritional deficiencies or diseases, leading to a decline in muscle mass. Current studies indicate that skeletal muscle atrophy is closely associated with an imbalance between protein synthesis and degradation, driven by multiple factors such as inflammation, oxidative stress, autophagy, and apoptosis [1-3]. Due to the complexity of its molecular mechanisms, effective therapeutic strategies are lacking, and traditional approaches like rehabilitation training and pharmacological interventions show limited efficacy. Therefore, exploring more effective treatments is imperative. Stem cell therapy, with its unique regenerative potential and immunomodulatory properties, offers a promising avenue for treating this condition. In the current issue of the World Journal of Stem Cells, Ying-Jie Wang and colleagues published a review titled "Stem Cell Therapy: A Promising Therapeutic Approach for Skeletal Muscle Atrophy." The article summarizes the molecular mechanisms of muscle atrophy and highlights the applications of mesenchymal stem cells (MSCs), induced pluripotent stem cells (iPSCs), and their derivatives (e.g., exosomes) in treating skeletal muscle atrophy. These stem cells exert therapeutic effects by modulating inflammation, promoting angiogenesis, suppressing oxidative stress, and facilitating muscle regeneration. The authors also address challenges in clinical translation, including immune rejection, tumorigenic risks, inefficient stem cell homing, and the absence of standardized protocols. Despite these hurdles, the review expresses optimism about the future of stem cell therapy, particularly emphasizing the superior potential of stem cell-derived acellular therapies (e.g., exosomes) over traditional cell transplantation. We maintain a cautiously optimistic view regarding the prospects of stem cell therapy for skeletal muscle atrophy. While stem cell-based approaches, especially MSC- and exosome-based strategies, demonstrate promising safety and efficacy [4, 5], several issues must be resolved. These include addressing heterogeneity in stem cell sources, ensuring long-term safety, and establishing standardized protocols for clinical translation. Although iPSCs circumvent ethical concerns, their differentiation and purification techniques require optimization, and potential genetic mutations remain a concern. Exosomes, as acellular therapeutics, may reduce immune reactions; however, challenges in large-scale production and quality control persist. Therapeutic Potential of Stem Cells Stem cell therapy exhibits multidimensional potential in treating muscle atrophy. First, its mechanisms are highly synergistic: MSCs and iPSCs improve the muscle microenvironment by regulating inflammatory cytokines (e.g., suppressing IL-6 and TNF-α), promoting angiogenesis, inhibiting oxidative stress, and enhancing autophagy. Exosomes further amplify therapeutic effects by delivering functional miRNAs (e.g., miR-132-3p/FoxO3 axis) to delay protein degradation and stimulate regeneration [4, 6]. Second, exosomes as acellular carriers broaden clinical applicability: MSC-derived exosomes (e.g., hUC-MSC-Exos, ADSC-Exos) avoid immune rejection and tumorigenic risks associated with live cell transplantation. Their high biocompatibility and cargo of bioactive molecules (e.g., circHIPK3, AMPK/ULK1 regulators) enable targeted intervention in diabetes- or neuropathy-related atrophy, positioning them as pivotal tools for clinical translation [6, 7]. Third, iPSCs hold exceptional promise for personalized medicine. Their ability to differentiate into myogenic progenitor cells (MPCs) or motor neurons facilitates the reconstruction of neuromuscular junctions, offering precise repair for genetic atrophy (e.g., facioscapulohumeral muscular dystrophy, FSHD). While autologous iPSCs mitigate immune rejection, clinical application demands improved differentiation efficiency and safety [8, 9]. Current Challenges and Solutions Clinical translation of stem cell therapy faces multiple challenges requiring innovative solutions. First, heterogeneity and standardization: MSC efficacy varies with donor age, tissue source (e.g., bone marrow, adipose, umbilical cord), and culture conditions [10]. Establishing unified quality control standards—via surface marker screening, secretome profiling, and single-cell sequencing—is critical to identify functional subpopulations and enable precision manufacturing [11]. Second, genetic instability and differentiation inefficiency hinder iPSC applications: reprogramming-induced mutations and inconsistent differentiation protocols (transgene-dependent or -independent) limit reliability [12]. Integrating non-integrative methods (e.g., mRNA reprogramming) and 3D organoid culture systems may optimize differentiation pathways [8]. Third, exosome scalability and targeting: natural exosomes suffer from low bioactive content and short half-lives. Engineering strategies (e.g., ligand modification or drug loading) can enhance tissue-specific delivery [13, 14], while microfluidic-nanocarrier systems may resolve production bottlenecks. Finally, accelerating clinical translation: preclinical studies predominantly rely on animal models; multicenter trials are needed to validate long-term safety (e.g., tumorigenicity, immune tolerance) [15, 16]. Combining stem cell therapy with anti-inflammatory agents (e.g., IL-1β inhibitors), rehabilitation, or gene editing (e.g., CRISPR-Cas9) may synergistically enhance efficacy [17, 18]. Future Directions Future research should prioritize interdisciplinary integration and precision strategies. First, mechanistic insights: single-cell and spatial transcriptomics can unravel dynamic interactions between stem cells and the muscle microenvironment (e.g., satellite cells, macrophages), identifying key regulatory nodes (e.g., Wnt/β-catenin, PI3K/Akt pathways) [3, 19]. Second, biomaterial innovations: smart hydrogels or electroconductive scaffolds combined with localized stem cell/exosome delivery systems could enhance homing efficiency and functional persistence [20, 21]. Third, personalized approaches: tailored therapies based on disease-specific etiologies (e.g., ALS, diabetic atrophy) and molecular subtypes (e.g., inflammatory signatures) are essential. For instance, AMPK-activated umbilical cord MSCs may rectify metabolic dysregulation in diabetic atrophy [22, 23]. Lastly, ethical and regulatory frameworks: international guidelines must standardize stem cell therapies and clarify regulatory classifications (e.g., exosomes as "drugs") to accelerate clinical translation. Stem cell therapy for skeletal muscle atrophy is transitioning from bench to bedside, yet critical hurdles—standardization, safety, and efficacy validation—remain. Integrating multidisciplinary technologies (e.g., synthetic biology, bioinformatics) and advancing translational research will bridge the gap between "laboratory breakthroughs" and "patient benefits." References: 1. Zhang, H., et al., Oxidative stress: Roles in skeletal muscle atrophy. Biochem Pharmacol, 2023. 214: p. 115664. 2. Ji, Y., et al., Inflammation: Roles in Skeletal Muscle Atrophy. Antioxidants (Basel), 2022. 11(9). 3. Liang, W., et al., Epigenetic control of skeletal muscle atrophy. Cell Mol Biol Lett, 2024. 29(1): p. 99. 4. Huang, Z., et al., Skeletal Muscle Atrophy Was Alleviated by Salidroside Through Suppressing Oxidative Stress and Inflammation During Denervation. Front Pharmacol, 2019. 10: p. 997. 5. Song, J., et al., Mesenchymal stromal cells ameliorate diabetes-induced muscle atrophy through exosomes by enhancing AMPK/ULK1-mediated autophagy. J Cachexia Sarcopenia Muscle, 2023. 14(2): p. 915-929. 6. Archacka, K., et al., Hypoxia preconditioned bone marrow-derived mesenchymal stromal/stem cells enhance myoblast fusion and skeletal muscle regeneration. Stem Cell Res Ther, 2021. 12(1): p. 448. 7. Leong, J., et al., Surface Tethering of Inflammation-Modulatory Nanostimulators to Stem Cells for Ischemic Muscle Repair. ACS Nano, 2020. 14(5): p. 5298-5313. 8. Kim, H., et al., Genomic Safe Harbor Expression of PAX7 for the Generation of Engraftable Myogenic Progenitors. Stem Cell Reports, 2021. 16(1): p. 10-19. 9. Azzag, K., et al., Transplantation of PSC-derived myogenic progenitors counteracts disease phenotypes in FSHD mice. NPJ Regen Med, 2022. 7(1): p. 43. 10. Li, J., et al., The heterogeneity of mesenchymal stem cells: an important issue to be addressed in cell therapy. Stem Cell Res Ther, 2023. 14(1): p. 381. 11. Oguma, Y., et al., Single-cell RNA sequencing reveals different signatures of mesenchymal stromal cell pluripotent-like and multipotent populations. iScience, 2022. 25(11): p. 105395. 12. Shamsian, A., et al., Cancer cells as a new source of induced pluripotent stem cells. Stem Cell Res Ther, 2022. 13(1): p. 459. 13. Rezaie, J., et al., Mesenchymal stem cells derived extracellular vesicles: A promising nanomedicine for drug delivery system. Biochem Pharmacol, 2022. 203: p. 115167. 14. Yang, Q., et al., Exosomes-loaded electroconductive nerve dressing for nerve regeneration and pain relief against diabetic peripheral nerve injury. Bioact Mater, 2023. 26: p. 194-215. 15. Drela, K., et al., Experimental Strategies of Mesenchymal Stem Cell Propagation: Adverse Events and Potential Risk of Functional Changes. Stem Cells Int, 2019. 2019: p. 7012692. 16. Deuse, T., et al., Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients. Nat Biotechnol, 2019. 37(3): p. 252-258. 17. Iyer, S.R., et al., Exosomes Isolated From Platelet-Rich Plasma and Mesenchymal Stem Cells Promote Recovery of Function After Muscle Injury. Am J Sports Med, 2020. 48(9): p. 2277-2286. 18. Chang, M., et al., Duchenne muscular dystrophy: pathogenesis and promising therapies. J Neurol, 2023. 270(8): p. 3733-3749. 19. Sartori, R., V. Romanello, and M. Sandri, Mechanisms of muscle atrophy and hypertrophy: implications in health and disease. Nat Commun, 2021. 12(1): p. 330. 20. Luo, W., et al., Biomaterials-Based Technologies in Skeletal Muscle Tissue Engineering. Adv Healthc Mater, 2024. 13(18): p. e2304196. 21. Shan, Y., et al., Pharmacokinetic characteristics of mesenchymal stem cells in translational challenges. Signal Transduct Target Ther, 2024. 9(1): p. 242. 22. Shen, Y., et al., Diabetic Muscular Atrophy: Molecular Mechanisms and Promising Therapies. Front Endocrinol (Lausanne), 2022. 13: p. 917113. 23. Yeo, C.J.J., E.F. Tizzano, and B.T. Darras, Challenges and opportunities in spinal muscular atrophy therapeutics. Lancet Neurol, 2024. 23(2): p. 205-218. "
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Wang YJ, Chen ZH, Shen YT, Wang KX, Han YM, Zhang C, Yang XM, Chen BQ. Stem cell therapy: A promising therapeutic approach for skeletal muscle atrophy. World J Stem Cells 2025; 17(2): 98693
6
"Top-down therapy for Crohn's disease (CD) involves starting with the most potent medications, such as biologics and immunomodulators, ..."
[Read more]
"Top-down therapy for Crohn's disease (CD) involves starting with the most potent medications, such as biologics and immunomodulators, immediately after early diagnosis. This strategy may lead to rapid induction of remission, promotion of mucosal healing, prevention of complications, and reduced need for surgery. However, the background factors influencing this top-down therapy have not been sufficiently examined. A recent report on a Japanese cohort found that factors significantly associated with the recent top-down treatment approach were male gender, perianal lesions, no immunomodulators, and anti-tumor necrosis factor therapy. (Miyoshi J, Yoon A, Matsuura M, Hisamatsu T. Real-world use of biologics during the first year of treatment for newly diagnosed Crohn's disease in Japan: a claims analysis from 2010 to 2021. Intest Res. 2025 [PMID: 39848334 DOI: 10.5217/ir.2024.00082]) Top-down therapy for CD should be considered case-by-case, weighing potential benefits against risks and costs. As the authors suggest, identifying patients with a high genetic predisposition for CD may help predict their response to medications, the risk of side effects, and the cost-effectiveness. Further investigation in this area is desirable. "
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Fan YH, Wang MW, Gao YN, Li WM, Jiao Y. Genetic and environmental factors influencing Crohn’s disease. World J Gastrointest Surg 2025; 17(3): 98526
7
"Suggested Title:From Weakness to Wellness: The Role of Stem Cells in Muscle Atrophy Recovery A. Clarity and Conciseness • Some ..."
[Read more]
"Suggested Title:From Weakness to Wellness: The Role of Stem Cells in Muscle Atrophy Recovery A. Clarity and Conciseness • Some sections, particularly those on molecular mechanisms, are dense and could benefit from simplification or restructuring. B. Novelty and Critical Analysis • The review summarizes existing knowledge well but lacks critical analysis of conflicting findings. • Consider discussing limitations of existing studies, such as sample size issues in preclinical models, potential biases, and reproducibility concerns. • More emphasis could be placed on recent breakthroughs or innovative approaches in stem cell therapy, particularly in clinical trials. C. Clinical Relevance and Future Directions • The discussion of clinical applications is somewhat broad. It would be beneficial to include: o Specific ongoing clinical trials (if available). o A comparison of animal models vs. human studies to highlight translational challenges. • The challenges section should offer potential solutions or strategies to overcome issues like immune rejection, tumorigenicity, and ethical concerns. D. Specific Suggestions for Improvement • Introduction: Emphasize the gap in current treatments that stem cell therapy aims to address. • Current Treatment Strategies: Compare rehabilitation and pharmacological treatments with stem cell therapy in terms of: Efficacy, Limitations, Side effects. • Exosome Therapy: This part is well-detailed, but it could benefit from a discussion on manufacturing challenges and standardization issues for clinical application. • Conclusion: Strengthen the future perspectives by suggesting research directions or potential improvements in stem cell delivery methods. "
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Wang YJ, Chen ZH, Shen YT, Wang KX, Han YM, Zhang C, Yang XM, Chen BQ. Stem cell therapy: A promising therapeutic approach for skeletal muscle atrophy. World J Stem Cells 2025; 17(2): 98693
8
"This review presents a comprehensive analysis of the role of Traditional Chinese Medicine (TCM) in the treatment of chronic atrophic ..."
[Read more]
"This review presents a comprehensive analysis of the role of Traditional Chinese Medicine (TCM) in the treatment of chronic atrophic gastritis (CAG), highlighting its multi-targeted therapeutic effects, including gastric mucosal protection, modulation of inflammatory responses, and improvement of microcirculation. The discussion is well-supported by clinical studies and meta-analyses, underscoring the potential benefits of specific herbal compounds such as berberine, morroniside, and notoginsenoside R1. However, the review also acknowledges a key challenge—the lack of standardized research methodologies and evaluation criteria, which limits the broader clinical application of TCM. While the evidence presented suggests promising therapeutic effects, future research should focus on large-scale randomized controlled trials to further validate these findings and establish consistent guidelines for integrating TCM into mainstream gastroenterology practice. Additionally, a more detailed discussion on potential interactions between TCM and conventional Western therapies would strengthen the clinical relevance of this review. Overall, this article makes a valuable contribution to the understanding of CAG management and provides a strong foundation for future research in this field. "
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Wang L, Lian YJ, Dong JS, Liu MK, Liu HL, Cao ZM, Wang QN, Lyu WL, Bai YN. Traditional Chinese medicine for chronic atrophic gastritis: Efficacy, mechanisms and targets. World J Gastroenterol 2025; 31(9): 102053
9
"The study by Real Martinez et al. provides valuable insights into the role of circulating myokines such as irisin and FGF21 in MASLD, ..."
[Read more]
"The study by Real Martinez et al. provides valuable insights into the role of circulating myokines such as irisin and FGF21 in MASLD, particularly their association with severe steatosis and advanced liver fibrosis. However, the absence of a relationship between skeletal muscle alterations (SMAs) and liver fibrosis stages raises intriguing questions. Could the lack of association be attributed to the heterogeneity of the cohort, or might it suggest that SMAs play a more indirect role in MASLD progression? Additionally, how might other metabolic or inflammatory pathways, not directly evaluated in this study, influence the interplay between muscle health and liver disease? Further studies exploring these aspects, especially in longitudinal designs or larger cohorts, would be invaluable in clarifying these relationships and their implications for clinical practice. "
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Real Martinez Y, Fernandez-Garcia CE, Fuertes-Yebra E, Calvo Soto M, Berlana A, Barrios V, Caldas M, Gonzalez Moreno L, Garcia-Buey L, Molina Baena B, Sampedro-Nuñez M, Beceiro MJ, García-Monzón C, González-Rodríguez Á. Assessment of skeletal muscle alterations and circulating myokines in metabolic dysfunction-associated steatotic liver disease: A cross-sectional study. World J Gastroenterol 2025; 31(7): 100039
10
"I congratulate the authors for the publication of their write up. It is well written with practical points. The information on greater ..."
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"I congratulate the authors for the publication of their write up. It is well written with practical points. The information on greater likelihood of antibody generation with premixed insulins was new to me, although I believe it would have been partly due to the highly prevalent use of this form of insulin. I would like the authors to understand this point as well while promoting the advantages of the newer insulins. In the international guidelines, at diagnosis of diabetes if the blood glucose levels are above 300 mg/dl and/or glycosylated hemoglobin level is more than 10 %, it is suggested to start the patient on insulin to reduce the glucotoxicity. Once the blood glucose levels reduce, say after 2-3 weeks, the patient may be switched to oral anti-diabetic agents. Such a guideline recommended practice is regularly followed in developing countries such as ours. In such a situation I have observed that the acceptance rate of premixed insulin which involves two pricks, is a lot better than that of multiple short acting insulin doses along with basal insulin. Since the duration of premixed insulin therapy in this context is short, the possible side effects of anti-insulin antibody generation as well as lipodystrophy are less likely. "
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Xia Y, Hu Y, Ma JH. Premixed insulin: Advantages, disadvantages, and future. World J Diabetes 2025; 16(3): 102526
11
"This study presents an evaluation of a novel contrast-enhanced catheter with a chamfered tip. Achieving selective biliary cannulation ..."
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"This study presents an evaluation of a novel contrast-enhanced catheter with a chamfered tip. Achieving selective biliary cannulation is one of the most challenging endoscopic maneuver. We congratulate the authors on demonstrating in this paper that a novel device granted higher rates of biliary cannulation when retrospectively compared to a standard sphincterotome. However, a few points warrant further discussion: 1. Generalizability: As a single-center retrospective study, the external validity of these findings could be enhanced with multicenter randomized trials. Variations in patient populations, procedural techniques, and institutional expertise might influence outcomes. 2. Non-expert outcomes: The results indicate a lack of significant improvement in outcomes among non-experts or trainees using the novel catheter. This suggests the device's utility may be contingent on the operator's skill. We also noticed that the expert performed procedure percentage was slightly higher (57% vs 50%) in the novel cathether group, and, although not statistically significant, this could explain the lower use of advanced or rescue cannulation techniques. 3. Adverse Events (AEs): While the overall AE rates were low and comparable between groups, the trend toward fewer cases of PEP with the novel catheter merits closer scrutiny in larger cohorts as this could be an advantage in patients at risk for PEP. On the other hand, the non-statistically significant difference between the two groups in PEP incidence suggests us that the device used to achieve initial selective cannulation maybe isn’t that relevant in increasing PEP risk or incidence, but this should be confirmed in larger studies. 4. Cost-effectiveness: Although not discussed, evaluating the cost implications of adopting this catheter, including potential savings from reduced reliance on rescue techniques and decreased procedural times, would be beneficial for broader clinical adoption. We should also think of the negative aspects: for example, like stone clearance, achieving cannulation with a catheter would require a subsequent switch to a sphincterotome, increasing procedure length and costs, as you would be using two devices instead of one to achieve cannulation. 5. Papilla characteristics: we noticed that in the baseline characteristics intradiverticular papillas and oral oriented papillas were less represented in the catheter group. These types of papilla could benefit of the angling capabilities of a sphincterotome, so this could be a bias that needs to be furthermore cleared. In our experience the angling capabilities of a sphincterotome are crucial in achieving bile duct cannulation in difficult situations. 6. Malignant disease: we do know that malignant diseases (e.g. pancreatic cancer) affecting the ampullar area negatively affect rates of cannulation and increase the need for rescue or advanced techniques of cannulation. This point could have been furthermore discussed by making a distinction between cannulation failures in the setting of benign vs. malignant disease in both groups. In conclusion, this study gives us valuable insights into advancing ERCP outcomes through innovative device design. We must experiment with more designs to compare results and finally choose the best device for cannulation in unexpected and difficult anatomies. "
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Kaneko T, Kida M, Kurosu T, Kitahara G, Koyama S, Nomura N, Tahara K, Kusano C. Outcomes of bile duct cannulation using a novel contrast-enhanced catheter: A single-center, retrospective cohort study. World J Gastrointest Endosc 2025; 17(1): 97840
12
"As a colorectal surgeon interested in colorectal cancer and the microbiome, I found this study highly relevant. The authors ..."
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"As a colorectal surgeon interested in colorectal cancer and the microbiome, I found this study highly relevant. The authors effectively highlight differences in mucosa-associated colonic microbiota between colorectal cancer (CRC) and non-CRC patients in Indonesia. A key strength is the focus on mucosal rather than fecal microbiota, providing a clearer picture of the tumor microenvironment. The use of 16S rRNA sequencing with Oxford Nanopore Technologies enables detailed bacterial diversity analysis at the genus and species levels. The study confirms the increased presence of Fusobacterium nucleatum and Bacteroides fragilis in CRC patients, supporting the link between microbial dysbiosis and carcinogenesis. The diagnostic potential of these bacterial markers is particularly noteworthy. Further research with larger sample sizes and functional analyses, such as metagenomics or metabolomics, would enhance understanding of microbiota’s role in CRC. Additionally, while this study offers important insights for Asia, global research is needed to assess regional differences and their impact on CRC diagnostics and treatment. "
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Darnindro N, Abdullah M, Sukartini N, Rumende CM, Pitarini A, Nursyirwan SA, Fauzi A, Makmun D, Nelwan EJ, Shatri H, Rinaldi I, Tanadi C. Differences in diversity and composition of mucosa-associated colonic microbiota in colorectal cancer and non-colorectal cancer in Indonesia. World J Gastroenterol 2025; 31(7): 100051
13
"The manuscript is very clinically relevant. Here's a suggestion. Authors should provide the data on patients undergoing colonoscopy ..."
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"The manuscript is very clinically relevant. Here's a suggestion. Authors should provide the data on patients undergoing colonoscopy prior to capsule endoscopy examination. The retention rate of capsule endoscopy at 72 hours was 42.2%, which is still relatively high.It helps to reduce capsule retention in the colon after colonoscopy examination. "
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O'Hara FJ, Costigan C, McNamara D. Extended 72-hour patency capsule protocol improves functional patency rates in high-risk patients undergoing capsule endoscopy. World J Gastrointest Endosc 2024; 16(12): 661-667
14
"This case report highlights the importance of en-bloc resection without fragmentation during endoscopic procedures and the challenges ..."
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"This case report highlights the importance of en-bloc resection without fragmentation during endoscopic procedures and the challenges of endoscopic treatment for anal canal cancer. Traditionally, anal lesions have been primarily managed by surgeons, but ESD-related technique is performed mainly by the gastrointestinal endoscopists of internal medicine. Future collaboration between internal medicine and surgery departments will be crucial. Surgery for anal cancer can significantly decrease patients' quality of life, which is why the authors' dedication to endoscopic treatment and follow-up is commendable. Anal canal cancer is rare, and it will be essential to determine which cases are suitable for endoscopic therapy in the future. With the increasing prevalence of inflammatory bowel diseases in Asian regions, a rise in anal cancer cases associated with conditions like Crohn's disease is anticipated. Further case reports in this field are desirable. "
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Kinoshita M, Maruyama T, Hike S, Hirosuna T, Kainuma S, Kinoshita K, Nakano A, Ohira G, Uesato M, Matsubara H. Complete resection of recurrent anal canal cancer using endoscopic submucosal dissection and transanal resection: A case report. World J Gastrointest Endosc 2025; 17(1): 101119
15
"This is an excellent and insightful article. The authors have provided a comprehensive overview of the most impactful studies in the ..."
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"This is an excellent and insightful article. The authors have provided a comprehensive overview of the most impactful studies in the field of gastrointestinal endoscopy. It has greatly enhanced my understanding of the current research landscape and has inspired me to define more focused and meaningful directions for my own research in this area. "
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Sui J, Luo JS, Xiong C, Tang CY, Peng YH, Zhou R. Bibliometric analysis on the top one hundred cited studies on gastrointestinal endoscopy. World J Gastrointest Endosc 2025; 17(1): 100219
16
"This paper examines the differences in proficiency of AI tools for IBD patients and is considered a critical study for the inevitable ..."
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"This paper examines the differences in proficiency of AI tools for IBD patients and is considered a critical study for the inevitable future utilization of large language models in healthcare. However, it is merely a comparative study of large language models, and it remains unclear whether it contributes to improving IBD patients' literacy. Regarding patient education, Crohn's disease and ulcerative colitis belong to different categories, making it challenging to evaluate IBD as a whole comprehensively. Separate evaluations for ulcerative colitis and Crohn's disease patients would be preferable. Furthermore, large language models alone are insufficient for shared decision-making that considers patients' social backgrounds for treatment selection, including biological agents (especially for Crohn's disease). Simply improving knowledge on several items through large language models may not be enough for clinical application. Future evaluations using large language models should address these points. "
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Zhang Y, Wan XH, Kong QZ, Liu H, Liu J, Guo J, Yang XY, Zuo XL, Li YQ. Evaluating large language models as patient education tools for inflammatory bowel disease: A comparative study. World J Gastroenterol 2025; 31(6): 102090
17
"Dear editor, this is a review that summarizes the most recent evidence focused on the safety of the peroral endoscopic myotomy (POEM). ..."
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"Dear editor, this is a review that summarizes the most recent evidence focused on the safety of the peroral endoscopic myotomy (POEM). The manuscript is well written. However, I found some inaccuracies in the background. The style, language and grammar are appropriate. Since there are no figures or tables in the paper I answered no to the dedicated questions. Although the safety of POEM is well explained, superficial informations were provided on the precision and the post-procedural management. Therefore, I would focus the article mainly on the safety, explaining better the post-procedural management. "
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Christodoulidis G, Tsagkidou K, Koumarelas KE, Kouliou MN. Advances and challenges in peroral endoscopic myotomy: Safety, precision, and post-procedure management. World J Gastroenterol 2025; 31(5): 97574
18
"This case is an extensively worked-up and well-written report. Best regards to the team. Stroke is not a clear-cut biophysics in ..."
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"This case is an extensively worked-up and well-written report. Best regards to the team. Stroke is not a clear-cut biophysics in neurology, with challenges in the clinical-radiological correlation encountered so often in clinical practice. As in this case, the work-up in SPECT could not convincingly determine theexact biomechanism of the clinical phenomena. However, it opened up information for future scopes of research into lacunar strokes. DSA, functional MRI, and Perfusion mismatch studies can also help in this type of situations. In contrast, the treatment is fairly less complicated in lacunar stroke. "
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Tsai YH, Chen YH, Chao TC, Lin LF, Chang ST. New type of lacunar stroke presenting in brain perfusion images: A case report. World J Neurol 2024; 10(1): 98672
19
"Fu et al.'s recent study published in the World Journal of Psychiatry examines a complex connection between parenting stress, various ..."
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"Fu et al.'s recent study published in the World Journal of Psychiatry examines a complex connection between parenting stress, various family parenting styles, and the behavioral and emotional challenges that children experience. This study highlights the need for appropriate emotional management during the preschool years, demonstrating how differences in parental stress may have a significant impact on children's early emotional health. The analytical strength of this study is really impressive. The authors use structural equation modeling (SEM) to give a detailed examination of how different parenting styles mediate the relationships between these factors. Moreover, comprehensive questionnaire data collection contributes to a better understanding of family dynamics in a variety of environments. According to the findings, parents report high levels of stress, which suggests that they face constant challenges. The study discovers a link between "hostile/coercive" parenting and problem behaviors in children, revealing the deleterious effects of negative strategies for parenting. This conclusion is consistent with previous research, which emphasizes the importance of understanding how inadequate parenting may lead to behavioral problems in children. Conversely, the negative connection with "supportive/engaged" parenting implies that positive approaches might provide large protective benefits, emphasizing the importance of specific treatments. Besides, this study emphasizes how parenting styles serve as mediators in the relationship between parental stress and children's emotional health. The data show a 28.99% mediation impact, indicating that how parents handle stress influences the behaviors of their kids through their strategies for parenting. This finding not only strengthens the foundation for designing personalized therapies, but it also emphasizes the important need to improve parental practices. Also, the study points out the importance of providing parents with evidence-based strategies for managing their emotional health, with a focus on both parental and child well-being. The study aims to establish a caring environment for preschoolers by giving practical ways to reduce stress and promoting positive parenting behaviors. It focuses on the broader impacts of various parenting styles, implying that investing in parental support systems is important for enhancing children's mental health and promoting total family happiness. This perspective is consistent with current trends in mental health initiatives and requires a comprehensive effort to address families' emotional needs, supplying the framework for future research in this important area. Although Fu et al.'s work contributes significantly to our understanding of the link between parental stress and children's behavior, future research might profit from using a longitudinal strategy. Such an approach might allow researchers to investigate the changing dynamics of parental stress and child behavior over time, leading to a more comprehensive explanation of their causal relationships. Longitudinal studies may track how changes in parental stress affect the growth path of children's behavior by following the same set of participants at different points in time. This method not only gives a more in-depth understanding of these dynamics, but it also identifies potential mediators and moderators, offering light on the underlying reasons of the connections. Finally, this strategy may help us understand how the family environment affects children's developmental achievement. "
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Fu ZW, Li YJ, Yu R, Guo RQ, Gao LX, Zhao SX. Relationship between parenting stress and behavioral and emotional problems in preschool children: A mediation effect analysis. World J Psychiatry 2025; 15(1): 100068
20
"There is a need for non-invasive methods of evaluating mucosal healing in the small bowel. This study applies the principles of ..."
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"There is a need for non-invasive methods of evaluating mucosal healing in the small bowel. This study applies the principles of radiomics using small bowel CTE to develop a predictive normogram capable of predicting mucosal healing. Despite the study's stated limitations, it adds to the current literature, and extends the emerging field of radiomics in Crohn's disease. "
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Ding H, Fang YY, Fan WJ, Zhang CY, Wang SF, Hu J, Han W, Mei Q. Computed tomography enterography-based radiomics for assessing mucosal healing in patients with small bowel Crohn's disease. World J Gastroenterol 2025; 31(3): 102283
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