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Clinical Trial
. 1975 Dec 19;9(2-3):131-4.
doi: 10.1007/BF00614009.

Effect of zinc sulphate on the absorption of tetracycline and doxycycline in man

O Penttilä, H Hurme, P J Neuvonen
Clinical Trial

Effect of zinc sulphate on the absorption of tetracycline and doxycycline in man

O Penttilä et al. Eur J Clin Pharmacol. .

Abstract

A possible interaction between zinc sulphate and tetracycline or doxycycline was examined in a cross-over study in seven volunteers. A single dose of zinc sulphate (45 mg Zn++) was given simultaneously with tetracycline hydrochloride (500 mg) or doxycyline chloride (200 mg). The serum concentration of tetracycline, the area under the serum tetracycline concentration-time curve and the excretion of tetracycline in urine were reduced by about 30% (p less than 0.05) from the respective control values. The absorption of doxycycline was not influenced significantly by zinc sulphate. The clinical significance of the zinc-tetracycline interaction seems to be of limited importance.

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