Molecular forms of prostate-specific antigen and the human kallikrein gene family: a new era - PubMed Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1995 May;45(5):729-44.
doi: 10.1016/s0090-4295(99)80076-4.

Molecular forms of prostate-specific antigen and the human kallikrein gene family: a new era

R T McCormack  1 , H G Rittenhouse, J A Finlay, R L Sokoloff, T J Wang, R L Wolfert, H Lilja, J E Oesterling
Affiliations
Review

Molecular forms of prostate-specific antigen and the human kallikrein gene family: a new era

R T McCormack et al. Urology. 1995 May.

Abstract

Without question, much has been learned about the glycoprotein PSA in recent years. By increasing our understanding of this tumor marker's biochemical and physiologic properties, we will be able to improve its clinical utility. The discovery of the various molecular forms of PSA represents a significant advancement. Knowing the concentration and ratio of these PSA forms will be valuable in deciding which patients require further evaluation with transrectal ultrasound and prostate biopsy and which men can be monitored safely without undergoing further invasive testing. This information will be most valuable in treating the patient with a mildly elevated serum PSA level. Although assays are not yet available to detect specifically hK2, the striking similarities of hK2 to PSA, including selective expression in the prostate, suggest that this marker may also prove useful in prostate cancer management. Indeed, a new era of PSA testing has been entered, and the entire field of prostate cancer will benefit.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

LinkOut - more resources