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. 1980 Nov;63(6):1344-54.

Quality assurance in the analysis of foods and trace constituents

W Horwitz, L R Kamps, K W Boyer
  • PMID: 7451398

Quality assurance in the analysis of foods and trace constituents

W Horwitz et al. J Assoc Off Anal Chem. 1980 Nov.

Abstract

An examination of the results of over 50 interlaboratory collaborative studies conducted by the AOAC on various commodities for numerous analytes shows a relationship between the mean coefficient of variation (CV), expressed as powers of 2, with the mean concentration measured, expressed as powers of 10, independent of the determinative method. Some typical CV values are: drug formulations at a 1% concentration, 2%; sulfonamides in feeds at a 0.01% concentration, 4%; pesticide residues and toxic elements, 10(-6) (1 ppm), 16%; and aflatoxins 10(-8) (10 ppb), 32%. Analytical work at trace levels must be constantly monitored through analysis of reference materials and surrogate samples, and by independent replication.

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