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. 2019 Mar 27;28(151):180096.
doi: 10.1183/16000617.0096-2018. Print 2019 Mar 31.

Receptor for advanced glycation end-products and environmental exposure related obstructive airways disease: a systematic review

Syed H Haider  1   2 , Assad Oskuei  1 , George Crowley  1 , Sophia Kwon  1 , Rachel Lam  1 , Jessica Riggs  1 , Mena Mikhail  1 , Angela Talusan  1 , Arul Veerappan  1 , James S Kim  1 , Erin J Caraher  1 , Anna Nolan  3   2   4
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Receptor for advanced glycation end-products and environmental exposure related obstructive airways disease: a systematic review

Syed H Haider et al. Eur Respir Rev. .

Abstract

Background: Our group has identified the receptor for advanced glycation end-products (RAGE) as a predictor of World Trade Center particulate matter associated lung injury. The aim of this systematic review is to assess the relationship between RAGE and obstructive airways disease secondary to environmental exposure.

Methods: A comprehensive search using PubMed and Embase was performed on January 5, 2018 utilising keywords focusing on environmental exposure, obstructive airways disease and RAGE and was registered with PROSPERO (CRD42018093834). We included original human research studies in English, focusing on pulmonary end-points associated with RAGE and environmental exposure.

Results: A total of 213 studies were identified by the initial search. After removing the duplicates and applying inclusion and exclusion criteria, we screened the titles and abstracts of 61 studies. Finally, 19 full-text articles were included. The exposures discussed in these articles include particulate matter (n=2) and cigarette smoke (n=17).

Conclusion: RAGE is a mediator of inflammation associated end-organ dysfunction such as obstructive airways disease. Soluble RAGE, a decoy receptor, may have a protective effect in some pulmonary processes. Overall, RAGE is biologically relevant in environmental exposure associated lung disease. Future investigations should focus on further understanding the role and therapeutic potential of RAGE in particulate matter exposure associated lung disease.

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Conflict of interest statement

Conflict of interest: S.H. Haider has nothing to disclose. Conflict of interest: A. Oskuei has nothing to disclose. Conflict of interest: G. Crowley has nothing to disclose. Conflict of interest: S. Kwon has nothing to disclose. Conflict of interest: R. Lam has nothing to disclose. Conflict of interest: J. Riggs has nothing to disclose. Conflict of interest: M. Mikhail has nothing to disclose. Conflict of interest: A. Talusan has nothing to disclose. Conflict of interest: A. Veerappan has nothing to disclose. Conflict of interest: J.S. Kim has nothing to disclose. Conflict of interest: E.J. Caraher has nothing to disclose. Conflict of interest: A. Nolan has nothing to disclose.

Figures

FIGURE 1
FIGURE 1
Flow diagram as per PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines [40]. OAD: obstructive airways disease; AGER: advanced glycation end-product receptor.
See this image and copyright information in PMC

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