Optical fluorescence imaging in oral cancer and potentially malignant disorders: A systematic review

doi:10.1111/odi.13071

. 2020 Apr;26(3):491-510.

doi: 10.1111/odi.13071. Epub 2019 Mar 26.

Optical fluorescence imaging in oral cancer and potentially malignant disorders: A systematic review

Lalima Tiwari¹, Omar Kujan¹, Camile S Farah²

Affiliations

¹ UWA Dental School, The University of Western Australia, Nedlands, Western Australia, Australia.
² Australian Centre for Oral Oncology Research & Education, Nedlands, Western Australia, Australia.

PMID: 30810255
DOI: 10.1111/odi.13071

Free article

Optical fluorescence imaging in oral cancer and potentially malignant disorders: A systematic review

Lalima Tiwari et al. Oral Dis. 2020 Apr.

Free article

. 2020 Apr;26(3):491-510.

doi: 10.1111/odi.13071. Epub 2019 Mar 26.

Authors

Lalima Tiwari¹, Omar Kujan¹, Camile S Farah²

Affiliations

¹ UWA Dental School, The University of Western Australia, Nedlands, Western Australia, Australia.
² Australian Centre for Oral Oncology Research & Education, Nedlands, Western Australia, Australia.

PMID: 30810255
DOI: 10.1111/odi.13071

Abstract

Objectives: This study aimed to systematically review the efficacy of direct optical fluorescence imaging as an adjunct to comprehensive oral examination in the clinical evaluation, risk assessment and surgical management of oral cancer and potentially malignant disorders.

Methods: Studies adopting autofluorescence devices, evaluating the efficacy of comprehensive oral examination and optical fluorescence imaging in detection, visualisation or management of oral squamous cell carcinoma or oral potentially malignant disorders, as well as discriminating oral epithelial dysplasia from other mucosal lesions, were included in the literature search across bibliographic databases until October 2018.

Results: Twenty-seven studies were found to be eligible for inclusion in qualitative analysis. Of these, only six studies demonstrated a low risk of bias across all domains of the methodological assessment tool (QUADAS-2). Optical fluorescence imaging demonstrated positive results, with higher sensitivity scores, increased lesion detection and visualisation than comprehensive oral examination alone in the clinical evaluation of oral squamous cell carcinoma and oral potentially malignant disorders.

Conclusions: This review provides promising evidence for the utilisation of optical fluorescence imaging as an adjunct to comprehensive oral examination in varying clinical settings. It is important that devices utilising optical fluorescence imaging are viewed strictly as clinical adjuncts and not specifically as diagnostic devices.

Keywords: autofluorescence; optical fluorescence imaging; oral cancer; oral potentially malignant disorders; systematic review.

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References

REFERENCES

1. Amirchaghmaghi, M., Mohtasham, N., Delavarian, Z., Shakeri, M. T., Hatami, M., & Mosannen Mozafari, P. (2018). The diagnostic value of the native fluorescence visualization device for early detection of premalignant/malignant lesions of the oral cavity. Photodiagnosis and Photodynamic Therapy, 21, 19-27. https://doi.org/10.1016/j.pdpdt.2017.10.019
1. Awan, K., Morgan, P. R., & Warnakulasuriya, S. (2011). Evaluation of an autofluorescence based imaging system (VELscopeTM) in the detection of oral potentially malignant disorders and benign keratoses. Oral Oncology, 47(4), 274-277. https://doi.org/10.1016/j.oraloncology.2011.02.001
1. Awan, K., Morgan, P. R., & Warnakulasuriya, S. (2015). Assessing the accuracy of autofluorescence, chemiluminescence and toluidine blue as diagnostic tools for oral potentially malignant disorders-a clinicopathological evaluation. Clinical Oral Investigations, 19(9), 2267-2272. https://doi.org/10.1007/s00784-015-1457-9
1. Awan, K. H., & Patil, S. (2015). Efficacy of autofluorescence imaging as an adjunctive technique for examination and detection of oral potentially malignant disorders: A systematic Review. The Journal of Contemporary Dental Practice, 16(9), 744-749. https://doi.org/10.5005/jp-journals-10024-1751
1. Babiuch, K., Chomyszyn-Gajewska, M., & Wyszyńska-Pawelec, G. (2012). The use of VELscope® for detection of oral potentially malignant disorders and cancers - A pilot study. Medical and Biological Sciences, 26(4), 11-16. https://doi.org/10.12775/v10251-012-0069-8

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[1] Amirchaghmaghi, M., Mohtasham, N., Delavarian, Z., Shakeri, M. T., Hatami, M., & Mosannen Mozafari, P. (2018). The diagnostic value of the native fluorescence visualization device for early detection of premalignant/malignant lesions of the oral cavity. Photodiagnosis and Photodynamic Therapy, 21, 19-27. https://doi.org/10.1016/j.pdpdt.2017.10.019

[2] Amirchaghmaghi, M., Mohtasham, N., Delavarian, Z., Shakeri, M. T., Hatami, M., & Mosannen Mozafari, P. (2018). The diagnostic value of the native fluorescence visualization device for early detection of premalignant/malignant lesions of the oral cavity. Photodiagnosis and Photodynamic Therapy, 21, 19-27. https://doi.org/10.1016/j.pdpdt.2017.10.019

[3] Awan, K., Morgan, P. R., & Warnakulasuriya, S. (2011). Evaluation of an autofluorescence based imaging system (VELscopeTM) in the detection of oral potentially malignant disorders and benign keratoses. Oral Oncology, 47(4), 274-277. https://doi.org/10.1016/j.oraloncology.2011.02.001

[4] Awan, K., Morgan, P. R., & Warnakulasuriya, S. (2011). Evaluation of an autofluorescence based imaging system (VELscopeTM) in the detection of oral potentially malignant disorders and benign keratoses. Oral Oncology, 47(4), 274-277. https://doi.org/10.1016/j.oraloncology.2011.02.001

[5] Awan, K., Morgan, P. R., & Warnakulasuriya, S. (2015). Assessing the accuracy of autofluorescence, chemiluminescence and toluidine blue as diagnostic tools for oral potentially malignant disorders-a clinicopathological evaluation. Clinical Oral Investigations, 19(9), 2267-2272. https://doi.org/10.1007/s00784-015-1457-9

[6] Awan, K., Morgan, P. R., & Warnakulasuriya, S. (2015). Assessing the accuracy of autofluorescence, chemiluminescence and toluidine blue as diagnostic tools for oral potentially malignant disorders-a clinicopathological evaluation. Clinical Oral Investigations, 19(9), 2267-2272. https://doi.org/10.1007/s00784-015-1457-9

[7] Awan, K. H., & Patil, S. (2015). Efficacy of autofluorescence imaging as an adjunctive technique for examination and detection of oral potentially malignant disorders: A systematic Review. The Journal of Contemporary Dental Practice, 16(9), 744-749. https://doi.org/10.5005/jp-journals-10024-1751

[8] Awan, K. H., & Patil, S. (2015). Efficacy of autofluorescence imaging as an adjunctive technique for examination and detection of oral potentially malignant disorders: A systematic Review. The Journal of Contemporary Dental Practice, 16(9), 744-749. https://doi.org/10.5005/jp-journals-10024-1751

[9] Babiuch, K., Chomyszyn-Gajewska, M., & Wyszyńska-Pawelec, G. (2012). The use of VELscope® for detection of oral potentially malignant disorders and cancers - A pilot study. Medical and Biological Sciences, 26(4), 11-16. https://doi.org/10.12775/v10251-012-0069-8

[10] Babiuch, K., Chomyszyn-Gajewska, M., & Wyszyńska-Pawelec, G. (2012). The use of VELscope® for detection of oral potentially malignant disorders and cancers - A pilot study. Medical and Biological Sciences, 26(4), 11-16. https://doi.org/10.12775/v10251-012-0069-8

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Optical fluorescence imaging in oral cancer and potentially malignant disorders: A systematic review

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Optical fluorescence imaging in oral cancer and potentially malignant disorders: A systematic review

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