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. 2016 Aug 2;7(31):50428-50436.
doi: 10.18632/oncotarget.10416.

Long non-coding RNAs: novel prognostic biomarkers for liver metastases in patients with early stage colorectal cancer

Hui Kong  1 , Ying Wu  1 , Mengou Zhu  2 , Changwen Zhai  3 , Jing Qian  1 , Xue Gao  4 , Shuyang Wang  1 , Yingyong Hou  3 , Shaohua Lu  3 , Hongguang Zhu  1   4
Affiliations

Long non-coding RNAs: novel prognostic biomarkers for liver metastases in patients with early stage colorectal cancer

Hui Kong et al. Oncotarget. .

Abstract

Liver metastasis is the primary cause of death for colorectal cancer (CRC) patients. To investigate the prognostic value of long non-coding RNAs (lncRNAs) on colorectal liver metastases, quantitative reverse-transcriptase PCR (quantitative RT-PCR) was performed on 15 lncRNAs in 51 stage IV CRC with liver metastases and 57 stage I/II CRC specimens. The expression levels of four lncRNAs (GAS5, H19, MEG3 and Yiya) were significantly different between liver metastases and primary tumors of stage IV CRC patients. Furthermore, the high expression levels of GAS5 and Yiya were significantly associated with future occurrence of liver metastases in early stage CRC patients. Kaplan-Meier analysis showed that the high expression levels of GAS5 or Yiya were correlated with poor prognosis of early stage CRC patients (p = 0.0206 and 0.0005 for GAS5 and Yiya, respectively). Yiya expression was proved to be an independent prognostic indicator of colorectal liver metastases in a multivariate analysis (relative risk = 10.7; p < 0.0001). Our study revealed that GAS5 and Yiya were promising prognostic biomarkers of liver metastases for early stage CRC patients.

Keywords: early stage colorectal cancer; liver metastasis; long non-coding RNA; prognostic biomarker; quantitative RT-PCR.

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Conflict of interest statement

The authors declare no conflicts of interests.

Figures

Figure 1
Figure 1. Kaplan-Meier curves of liver metastases on four candidate lncRNAs in patients with stage I/II CRC
A-D. Kaplan-Meier curve of GAS5, H19, MEG3 and Yiya, respectively. High, high expression level ≥ mean 2ΔCq; Low, low expression level < mean 2ΔCq.
Figure 2
Figure 2. Study design
LncRNA, long non-coding RNA; RT-PCR, reverse transcriptase polymerase chain reaction.
See this image and copyright information in PMC

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References

    1. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65:87–108. - PubMed
    1. Steeg PS. Tumor metastasis: mechanistic insights and clinical challenges. Nat Med. 2006;12:895–904. - PubMed
    1. National Cancer Institute: Surveillance, Epidemiology, and End Results (SEER 18) Program. SEER Stat Fact Sheets: Colon and Rectum Cancer. 2015 Mar; http://seer.cancer.gov/statfacts/html/colorect.html
    1. Turner JR, Lingen MW. Kumar V, Abbas AK, Aster JC. Robbins Basic Pathology. Philadelphia, PA: ELSEVIER SAUNDERS; 2013. Oral Cavity and Gastrointestinal Track; pp. 596–600.
    1. Siriwardena AK, Mason JM, Mullamitha S, Hancock HC, Jegatheeswaran S. Management of colorectal cancer presenting with synchronous liver metastases. Nat Rev Clin Oncol. 2014;11:446–59. - PubMed

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