Method development for the simultaneous determination of polybrominated, polychlorinated, mixed polybrominated/chlorinated dibenzo-p-dioxins and dibenzofurans, polychlorinated biphenyls and polybrominated diphenyl ethers in fish - PubMed Skip to main page content
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. 2015 Jan:118:72-80.
doi: 10.1016/j.chemosphere.2014.06.032. Epub 2014 Jul 9.

Method development for the simultaneous determination of polybrominated, polychlorinated, mixed polybrominated/chlorinated dibenzo-p-dioxins and dibenzofurans, polychlorinated biphenyls and polybrominated diphenyl ethers in fish

D Zacs  1 , J Rjabova  2 , A Viksna  3 , V Bartkevics  4
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Method development for the simultaneous determination of polybrominated, polychlorinated, mixed polybrominated/chlorinated dibenzo-p-dioxins and dibenzofurans, polychlorinated biphenyls and polybrominated diphenyl ethers in fish

D Zacs et al. Chemosphere. 2015 Jan.

Abstract

An analytical methodology was developed for simultaneous determination of five groups of persistent organic pollutants (POPs) including polybrominated, polychlorinated and mixed brominated-chlorinated dibenzo-p-dioxins and dibenzofurans (PBDD/DFs, PCDD/DFs and PXDD/DFs, respectively), polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in fish samples. The presented analytical approach was based on well established and robust method for determination of PCDD/DFs and PCBs, which was augmented with gas chromatography coupled to high resolution mass spectrometry (GC-HRMS) to include PBDEs, as well as poorly investigated PBDD/DFs and PXDD/DFs at toxicologically significant levels. Intensive clean-up and fractionation procedures in combination with optimized instrumental parameters provided reliable detection and quantification of these compounds. The application of (13)C12-labeled surrogates of analyzed compounds allowed the internal standardization and accurate measurement of selected contaminants. The developed procedure was validated while taking into account the Commission Regulation (EU) 252/2012 requirements for PCDD/DFs and PCBs, and was used to measure the occurrence of priority POPs in Baltic wild salmon.

Keywords: Fish; GC–HRMS; PBDD/DFs; POPs; PXDD/DFs; Simultaneous determination.

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